| Full name: nerve growth factor receptor | Alias Symbol: TNFRSF16|CD271|p75NTR | ||
| Type: protein-coding gene | Cytoband: 17q21.33 | ||
| Entrez ID: 4804 | HGNC ID: HGNC:7809 | Ensembl Gene: ENSG00000064300 | OMIM ID: 162010 |
| Drug and gene relationship at DGIdb | |||
NGFR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway | |
| hsa04015 | Rap1 signaling pathway | |
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04722 | Neurotrophin signaling pathway |
Expression of NGFR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NGFR | 4804 | 205858_at | 0.3910 | 0.4558 | |
| GSE20347 | NGFR | 4804 | 205858_at | 0.5736 | 0.0917 | |
| GSE23400 | NGFR | 4804 | 205858_at | 0.0899 | 0.2172 | |
| GSE26886 | NGFR | 4804 | 205858_at | 0.6141 | 0.0170 | |
| GSE29001 | NGFR | 4804 | 205858_at | 0.4198 | 0.2584 | |
| GSE38129 | NGFR | 4804 | 205858_at | 0.3936 | 0.1782 | |
| GSE45670 | NGFR | 4804 | 205858_at | 0.4320 | 0.0849 | |
| GSE53622 | NGFR | 4804 | 51856 | 0.3931 | 0.0800 | |
| GSE53624 | NGFR | 4804 | 51856 | 0.4683 | 0.0001 | |
| GSE63941 | NGFR | 4804 | 205858_at | 1.4618 | 0.0695 | |
| GSE77861 | NGFR | 4804 | 205858_at | -0.0182 | 0.9636 | |
| GSE97050 | NGFR | 4804 | A_23_P389897 | 0.7371 | 0.2395 | |
| SRP007169 | NGFR | 4804 | RNAseq | 0.9934 | 0.1050 | |
| SRP064894 | NGFR | 4804 | RNAseq | 1.1803 | 0.0011 | |
| SRP133303 | NGFR | 4804 | RNAseq | 0.8374 | 0.0462 | |
| SRP219564 | NGFR | 4804 | RNAseq | 0.4264 | 0.6691 | |
| TCGA | NGFR | 4804 | RNAseq | 0.0332 | 0.8880 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by NGFR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NGFR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NGFR | 4804 | 6 | 2 | 22 | |
| GSE20123 | NGFR | 4804 | 6 | 2 | 22 | |
| GSE43470 | NGFR | 4804 | 3 | 2 | 38 | |
| GSE46452 | NGFR | 4804 | 32 | 0 | 27 | |
| GSE47630 | NGFR | 4804 | 9 | 0 | 31 | |
| GSE54993 | NGFR | 4804 | 2 | 4 | 64 | |
| GSE54994 | NGFR | 4804 | 10 | 5 | 38 | |
| GSE60625 | NGFR | 4804 | 4 | 0 | 7 | |
| GSE74703 | NGFR | 4804 | 3 | 2 | 31 | |
| GSE74704 | NGFR | 4804 | 4 | 1 | 15 | |
| TCGA | NGFR | 4804 | 27 | 7 | 62 |
Total number of gains: 106; Total number of losses: 25; Total Number of normals: 357.
Somatic mutations of NGFR:
Generating mutation plots.
Highly correlated genes for NGFR:
Showing top 20/144 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NGFR | BPIFC | 0.754628 | 3 | 0 | 3 |
| NGFR | SAGE1 | 0.753704 | 3 | 0 | 3 |
| NGFR | CPXM1 | 0.726592 | 3 | 0 | 3 |
| NGFR | ERC2 | 0.704796 | 4 | 0 | 4 |
| NGFR | CA6 | 0.696836 | 4 | 0 | 4 |
| NGFR | FGF3 | 0.688459 | 6 | 0 | 5 |
| NGFR | METTL7B | 0.686378 | 4 | 0 | 3 |
| NGFR | NPTX2 | 0.679594 | 6 | 0 | 4 |
| NGFR | NDUFAF7 | 0.671659 | 3 | 0 | 3 |
| NGFR | NPFFR2 | 0.66246 | 3 | 0 | 3 |
| NGFR | ISL1 | 0.659204 | 3 | 0 | 3 |
| NGFR | BEX1 | 0.655777 | 4 | 0 | 4 |
| NGFR | SULT1E1 | 0.646443 | 4 | 0 | 3 |
| NGFR | FSTL5 | 0.641863 | 3 | 0 | 3 |
| NGFR | INSM1 | 0.633952 | 3 | 0 | 3 |
| NGFR | PTGIR | 0.632589 | 3 | 0 | 3 |
| NGFR | TMEM163 | 0.63087 | 3 | 0 | 3 |
| NGFR | CHI3L2 | 0.628553 | 3 | 0 | 3 |
| NGFR | NFKBIE | 0.627102 | 5 | 0 | 4 |
| NGFR | KSR2 | 0.62323 | 3 | 0 | 3 |
For details and further investigation, click here
