HK3

 

Full name: hexokinase 3 Alias Symbol: 
Type: protein-coding gene Cytoband: 5q35.2
Entrez ID: 3101 HGNC ID: HGNC:4925 Ensembl Gene: ENSG00000160883 OMIM ID: 142570
Drug and gene relationship at DGIdb

 

HK3 involved pathways:

KEGG pathway Description View
hsa04066HIF-1 signaling pathway
hsa04910Insulin signaling pathway
hsa04930Type II diabetes mellitus

 

Expression of HK3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 HK3 3101 205936_s_at 0.6716 0.2840
GSE20347 HK3 3101 205936_s_at 0.3051 0.0011
GSE23400 HK3 3101 205936_s_at 0.1485 0.0021
GSE26886 HK3 3101 205936_s_at 0.3085 0.0682
GSE29001 HK3 3101 205936_s_at 0.3921 0.0083
GSE38129 HK3 3101 205936_s_at 0.4162 0.0002
GSE45670 HK3 3101 205936_s_at 0.2224 0.0367
GSE53622 HK3 3101 132072 0.0629 0.3657
GSE53624 HK3 3101 132072 -0.6284 0.0000
GSE63941 HK3 3101 205936_s_at 0.0702 0.5464
GSE77861 HK3 3101 205936_s_at -0.0635 0.6809
GSE97050 HK3 3101 A_23_P213584 0.1094 0.8197
SRP064894 HK3 3101 RNAseq 1.8529 0.0001
SRP133303 HK3 3101 RNAseq 1.8560 0.0000
SRP159526 HK3 3101 RNAseq 1.8071 0.0094
SRP193095 HK3 3101 RNAseq 1.5120 0.0000
SRP219564 HK3 3101 RNAseq 1.9668 0.0524
TCGA HK3 3101 RNAseq 0.9375 0.0013

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by HK3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of HK3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 HK3 3101 2 13 15
GSE20123 HK3 3101 2 13 15
GSE43470 HK3 3101 1 11 31
GSE46452 HK3 3101 0 27 32
GSE47630 HK3 3101 0 20 20
GSE54993 HK3 3101 10 2 58
GSE54994 HK3 3101 2 17 34
GSE60625 HK3 3101 1 0 10
GSE74703 HK3 3101 1 7 28
GSE74704 HK3 3101 1 6 13
TCGA HK3 3101 7 35 54

Total number of gains: 27; Total number of losses: 151; Total Number of normals: 310.  

 

Somatic mutations of HK3:

 

Generating mutation plots.

 

Highly correlated genes for HK3:

 

Showing top 20/401 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
HK3FBXO150.815215303
HK3ISLR20.777316303
HK3PRR180.775956303
HK3SALL30.77093303
HK3NCR30.770695403
HK3NPBWR10.747104303
HK3PSPN0.740999303
HK3KRTAP4-10.737678303
HK3FXYD20.737256303
HK3REM20.734827303
HK3PAX20.732618303
HK3C19orf810.726911303
HK3S1PR40.726681404
HK3FOXE30.725864303
HK3ANGPT40.724204303
HK3CELF40.7214303
HK3SUN50.712809403
HK3LRRC30.711914404
HK3ADAMTS70.711125403
HK3SLC6A180.708458303

For details and further investigation, click here