| Full name: phosphodiesterase 6C | Alias Symbol: PDEA2|ACHM5|COD4 | ||
| Type: protein-coding gene | Cytoband: 10q23.33 | ||
| Entrez ID: 5146 | HGNC ID: HGNC:8787 | Ensembl Gene: ENSG00000095464 | OMIM ID: 600827 |
| Drug and gene relationship at DGIdb | |||
Expression of PDE6C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDE6C | 5146 | 211093_at | 0.0910 | 0.6609 | |
| GSE20347 | PDE6C | 5146 | 211093_at | 0.0475 | 0.2805 | |
| GSE23400 | PDE6C | 5146 | 211093_at | -0.0178 | 0.2131 | |
| GSE26886 | PDE6C | 5146 | 211093_at | 0.0977 | 0.1633 | |
| GSE29001 | PDE6C | 5146 | 211093_at | 0.0130 | 0.8948 | |
| GSE38129 | PDE6C | 5146 | 211093_at | 0.0400 | 0.2661 | |
| GSE45670 | PDE6C | 5146 | 211093_at | 0.0238 | 0.7226 | |
| GSE53622 | PDE6C | 5146 | 41048 | 0.0175 | 0.7970 | |
| GSE53624 | PDE6C | 5146 | 41048 | 0.1171 | 0.1186 | |
| GSE63941 | PDE6C | 5146 | 211093_at | 0.0430 | 0.6938 | |
| GSE77861 | PDE6C | 5146 | 211093_at | 0.0329 | 0.6679 | |
| GSE97050 | PDE6C | 5146 | A_23_P98070 | -0.1142 | 0.6366 | |
| SRP133303 | PDE6C | 5146 | RNAseq | 0.0458 | 0.7872 | |
| SRP219564 | PDE6C | 5146 | RNAseq | 0.8235 | 0.1020 | |
| TCGA | PDE6C | 5146 | RNAseq | 0.5525 | 0.5491 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PDE6C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDE6C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDE6C | 5146 | 0 | 8 | 22 | |
| GSE20123 | PDE6C | 5146 | 0 | 7 | 23 | |
| GSE43470 | PDE6C | 5146 | 0 | 7 | 36 | |
| GSE46452 | PDE6C | 5146 | 1 | 11 | 47 | |
| GSE47630 | PDE6C | 5146 | 2 | 14 | 24 | |
| GSE54993 | PDE6C | 5146 | 7 | 0 | 63 | |
| GSE54994 | PDE6C | 5146 | 1 | 10 | 42 | |
| GSE60625 | PDE6C | 5146 | 0 | 0 | 11 | |
| GSE74703 | PDE6C | 5146 | 0 | 5 | 31 | |
| GSE74704 | PDE6C | 5146 | 0 | 4 | 16 | |
| TCGA | PDE6C | 5146 | 6 | 26 | 64 |
Total number of gains: 17; Total number of losses: 92; Total Number of normals: 379.
Somatic mutations of PDE6C:
Generating mutation plots.
Highly correlated genes for PDE6C:
Showing top 20/276 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDE6C | OR5A1 | 0.82012 | 3 | 0 | 3 |
| PDE6C | TSSK3 | 0.810795 | 3 | 0 | 3 |
| PDE6C | TXNDC2 | 0.809358 | 3 | 0 | 3 |
| PDE6C | BSX | 0.807541 | 3 | 0 | 3 |
| PDE6C | INSC | 0.805669 | 3 | 0 | 3 |
| PDE6C | C1QL2 | 0.801365 | 3 | 0 | 3 |
| PDE6C | ISLR2 | 0.79565 | 3 | 0 | 3 |
| PDE6C | DDC | 0.775586 | 3 | 0 | 3 |
| PDE6C | DRGX | 0.775333 | 3 | 0 | 3 |
| PDE6C | ANKRD33B | 0.772484 | 4 | 0 | 4 |
| PDE6C | FFAR1 | 0.771087 | 3 | 0 | 3 |
| PDE6C | SLC22A12 | 0.766615 | 3 | 0 | 3 |
| PDE6C | CIB3 | 0.763932 | 3 | 0 | 3 |
| PDE6C | PSMB11 | 0.761056 | 3 | 0 | 3 |
| PDE6C | GPHA2 | 0.759556 | 3 | 0 | 3 |
| PDE6C | OR10W1 | 0.757414 | 3 | 0 | 3 |
| PDE6C | TTC21A | 0.749502 | 3 | 0 | 3 |
| PDE6C | KLHL14 | 0.747089 | 3 | 0 | 3 |
| PDE6C | USP49 | 0.74621 | 3 | 0 | 3 |
| PDE6C | YY2 | 0.741871 | 3 | 0 | 3 |
For details and further investigation, click here
