| Full name: potassium voltage-gated channel subfamily H member 8 | Alias Symbol: Kv12.1|elk3 | ||
| Type: protein-coding gene | Cytoband: 3p24.3 | ||
| Entrez ID: 131096 | HGNC ID: HGNC:18864 | Ensembl Gene: ENSG00000183960 | OMIM ID: 608260 |
| Drug and gene relationship at DGIdb | |||
Expression of KCNH8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KCNH8 | 131096 | 1552742_at | -0.2508 | 0.3841 | |
| GSE26886 | KCNH8 | 131096 | 1552742_at | 0.4952 | 0.1443 | |
| GSE45670 | KCNH8 | 131096 | 1552742_at | 0.1659 | 0.5638 | |
| GSE63941 | KCNH8 | 131096 | 1552742_at | 0.3398 | 0.4817 | |
| GSE77861 | KCNH8 | 131096 | 1552742_at | 0.0167 | 0.8772 | |
| GSE97050 | KCNH8 | 131096 | A_23_P170636 | 0.0930 | 0.6222 | |
| SRP133303 | KCNH8 | 131096 | RNAseq | 0.0911 | 0.9024 | |
| SRP159526 | KCNH8 | 131096 | RNAseq | 1.3895 | 0.0850 | |
| SRP219564 | KCNH8 | 131096 | RNAseq | -0.7982 | 0.4375 | |
| TCGA | KCNH8 | 131096 | RNAseq | -0.6021 | 0.1506 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KCNH8 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of KCNH8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KCNH8 | 131096 | 1 | 19 | 10 | |
| GSE20123 | KCNH8 | 131096 | 1 | 19 | 10 | |
| GSE43470 | KCNH8 | 131096 | 0 | 20 | 23 | |
| GSE46452 | KCNH8 | 131096 | 2 | 17 | 40 | |
| GSE47630 | KCNH8 | 131096 | 1 | 24 | 15 | |
| GSE54993 | KCNH8 | 131096 | 6 | 1 | 63 | |
| GSE54994 | KCNH8 | 131096 | 1 | 32 | 20 | |
| GSE60625 | KCNH8 | 131096 | 5 | 0 | 6 | |
| GSE74703 | KCNH8 | 131096 | 0 | 17 | 19 | |
| GSE74704 | KCNH8 | 131096 | 0 | 13 | 7 | |
| TCGA | KCNH8 | 131096 | 1 | 68 | 27 |
Total number of gains: 18; Total number of losses: 230; Total Number of normals: 240.
Somatic mutations of KCNH8:
Generating mutation plots.
Highly correlated genes for KCNH8:
Showing all 16 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KCNH8 | LGR6 | 0.732881 | 4 | 0 | 4 |
| KCNH8 | DIO3 | 0.717108 | 3 | 0 | 3 |
| KCNH8 | CHGB | 0.706994 | 4 | 0 | 3 |
| KCNH8 | KRTAP19-1 | 0.699278 | 4 | 0 | 3 |
| KCNH8 | FIGLA | 0.682084 | 3 | 0 | 3 |
| KCNH8 | DAPK1-IT1 | 0.677856 | 3 | 0 | 3 |
| KCNH8 | PRAME | 0.644426 | 3 | 0 | 3 |
| KCNH8 | ENPP1 | 0.639213 | 4 | 0 | 3 |
| KCNH8 | PRR15 | 0.616008 | 4 | 0 | 3 |
| KCNH8 | ACBD4 | 0.60491 | 3 | 0 | 3 |
| KCNH8 | PHF21B | 0.604764 | 4 | 0 | 3 |
| KCNH8 | TMEM68 | 0.59717 | 4 | 0 | 3 |
| KCNH8 | SLCO1A2 | 0.590598 | 5 | 0 | 4 |
| KCNH8 | FREM2 | 0.568168 | 4 | 0 | 3 |
| KCNH8 | ZFAT | 0.534001 | 5 | 0 | 3 |
| KCNH8 | C6orf15 | 0.511145 | 5 | 0 | 3 |
For details and further investigation, click here
