| Full name: iodothyronine deiodinase 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q32.31 | ||
| Entrez ID: 1735 | HGNC ID: HGNC:2885 | Ensembl Gene: ENSG00000197406 | OMIM ID: 601038 |
| Drug and gene relationship at DGIdb | |||
Expression of DIO3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DIO3 | 1735 | 207154_at | -0.2086 | 0.3753 | |
| GSE20347 | DIO3 | 1735 | 207154_at | -0.0338 | 0.6805 | |
| GSE23400 | DIO3 | 1735 | 207154_at | -0.0637 | 0.1381 | |
| GSE26886 | DIO3 | 1735 | 207154_at | 0.0893 | 0.5250 | |
| GSE29001 | DIO3 | 1735 | 207154_at | 0.0702 | 0.7468 | |
| GSE38129 | DIO3 | 1735 | 207154_at | -0.0418 | 0.5366 | |
| GSE45670 | DIO3 | 1735 | 207154_at | -0.2506 | 0.0117 | |
| GSE53622 | DIO3 | 1735 | 20610 | 0.0495 | 0.5589 | |
| GSE53624 | DIO3 | 1735 | 20610 | 0.2584 | 0.0019 | |
| GSE63941 | DIO3 | 1735 | 207154_at | 0.4291 | 0.1498 | |
| GSE77861 | DIO3 | 1735 | 207154_at | 0.0071 | 0.9671 | |
| GSE97050 | DIO3 | 1735 | A_23_P105923 | 0.2124 | 0.4159 | |
| SRP159526 | DIO3 | 1735 | RNAseq | -1.8234 | 0.0141 | |
| SRP219564 | DIO3 | 1735 | RNAseq | -1.2446 | 0.0852 | |
| TCGA | DIO3 | 1735 | RNAseq | -0.4489 | 0.3968 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by DIO3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DIO3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DIO3 | 1735 | 9 | 5 | 16 | |
| GSE20123 | DIO3 | 1735 | 9 | 4 | 17 | |
| GSE43470 | DIO3 | 1735 | 7 | 4 | 32 | |
| GSE46452 | DIO3 | 1735 | 18 | 3 | 38 | |
| GSE47630 | DIO3 | 1735 | 10 | 9 | 21 | |
| GSE54993 | DIO3 | 1735 | 3 | 8 | 59 | |
| GSE54994 | DIO3 | 1735 | 21 | 4 | 28 | |
| GSE60625 | DIO3 | 1735 | 0 | 2 | 9 | |
| GSE74703 | DIO3 | 1735 | 6 | 3 | 27 | |
| GSE74704 | DIO3 | 1735 | 5 | 3 | 12 | |
| TCGA | DIO3 | 1735 | 32 | 18 | 46 |
Total number of gains: 120; Total number of losses: 63; Total Number of normals: 305.
Somatic mutations of DIO3:
Generating mutation plots.
Highly correlated genes for DIO3:
Showing top 20/441 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DIO3 | GUCY2C | 0.815759 | 3 | 0 | 3 |
| DIO3 | USHBP1 | 0.795177 | 3 | 0 | 3 |
| DIO3 | SYCE3 | 0.7902 | 3 | 0 | 3 |
| DIO3 | OR10H1 | 0.766046 | 3 | 0 | 3 |
| DIO3 | ADAMTS13 | 0.733674 | 4 | 0 | 3 |
| DIO3 | SLC16A11 | 0.726292 | 3 | 0 | 3 |
| DIO3 | ZNF182 | 0.725145 | 3 | 0 | 3 |
| DIO3 | KIF26A | 0.724816 | 3 | 0 | 3 |
| DIO3 | LCT | 0.723907 | 4 | 0 | 4 |
| DIO3 | KCNH8 | 0.717108 | 3 | 0 | 3 |
| DIO3 | ALDH3B1 | 0.706321 | 3 | 0 | 3 |
| DIO3 | SPACA1 | 0.704409 | 3 | 0 | 3 |
| DIO3 | GABRA1 | 0.700628 | 3 | 0 | 3 |
| DIO3 | MAGEA8 | 0.697396 | 3 | 0 | 3 |
| DIO3 | SLC30A3 | 0.695544 | 4 | 0 | 4 |
| DIO3 | AOC2 | 0.686285 | 4 | 0 | 3 |
| DIO3 | L3MBTL1 | 0.686088 | 5 | 0 | 5 |
| DIO3 | NOXA1 | 0.681367 | 4 | 0 | 4 |
| DIO3 | OTOF | 0.681057 | 3 | 0 | 3 |
| DIO3 | EDDM3A | 0.677024 | 3 | 0 | 3 |
For details and further investigation, click here
