| Full name: preferentially expressed antigen in melanoma | Alias Symbol: CT130 | ||
| Type: protein-coding gene | Cytoband: 22q11.22 | ||
| Entrez ID: 23532 | HGNC ID: HGNC:9336 | Ensembl Gene: ENSG00000185686 | OMIM ID: 606021 |
| Drug and gene relationship at DGIdb | |||
Expression of PRAME:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRAME | 23532 | 204086_at | 1.3858 | 0.0918 | |
| GSE20347 | PRAME | 23532 | 204086_at | 0.9282 | 0.0003 | |
| GSE23400 | PRAME | 23532 | 204086_at | 0.5313 | 0.0002 | |
| GSE26886 | PRAME | 23532 | 204086_at | 1.2767 | 0.0007 | |
| GSE29001 | PRAME | 23532 | 204086_at | 0.8605 | 0.0829 | |
| GSE38129 | PRAME | 23532 | 204086_at | 1.5337 | 0.0000 | |
| GSE45670 | PRAME | 23532 | 204086_at | 1.2325 | 0.0323 | |
| GSE53622 | PRAME | 23532 | 54390 | 2.1881 | 0.0000 | |
| GSE53624 | PRAME | 23532 | 54390 | 1.8753 | 0.0000 | |
| GSE63941 | PRAME | 23532 | 204086_at | 2.1480 | 0.1825 | |
| GSE77861 | PRAME | 23532 | 204086_at | 0.7934 | 0.0596 | |
| GSE97050 | PRAME | 23532 | A_33_P3249349 | 0.1056 | 0.8126 | |
| SRP159526 | PRAME | 23532 | RNAseq | 7.1668 | 0.0000 | |
| TCGA | PRAME | 23532 | RNAseq | 3.1057 | 0.0000 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by PRAME expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRAME:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRAME | 23532 | 5 | 7 | 18 | |
| GSE20123 | PRAME | 23532 | 5 | 6 | 19 | |
| GSE43470 | PRAME | 23532 | 3 | 6 | 34 | |
| GSE46452 | PRAME | 23532 | 32 | 1 | 26 | |
| GSE47630 | PRAME | 23532 | 8 | 5 | 27 | |
| GSE54993 | PRAME | 23532 | 3 | 6 | 61 | |
| GSE54994 | PRAME | 23532 | 11 | 7 | 35 | |
| GSE60625 | PRAME | 23532 | 5 | 0 | 6 | |
| GSE74703 | PRAME | 23532 | 3 | 5 | 28 | |
| GSE74704 | PRAME | 23532 | 2 | 3 | 15 | |
| TCGA | PRAME | 23532 | 27 | 16 | 53 |
Total number of gains: 104; Total number of losses: 62; Total Number of normals: 322.
Somatic mutations of PRAME:
Generating mutation plots.
Highly correlated genes for PRAME:
Showing top 20/355 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRAME | CD8B | 0.772488 | 3 | 0 | 3 |
| PRAME | IVD | 0.685369 | 3 | 0 | 3 |
| PRAME | CDC34 | 0.684708 | 3 | 0 | 3 |
| PRAME | TRAPPC9 | 0.680148 | 3 | 0 | 3 |
| PRAME | ANXA10 | 0.679569 | 4 | 0 | 4 |
| PRAME | HCK | 0.679165 | 5 | 0 | 4 |
| PRAME | MAPK15 | 0.675896 | 3 | 0 | 3 |
| PRAME | MPP3 | 0.66455 | 4 | 0 | 4 |
| PRAME | APOL4 | 0.663089 | 3 | 0 | 3 |
| PRAME | PHKA2 | 0.65711 | 3 | 0 | 3 |
| PRAME | PGP | 0.654638 | 4 | 0 | 4 |
| PRAME | PODXL | 0.647195 | 5 | 0 | 4 |
| PRAME | FBXO15 | 0.646216 | 5 | 0 | 3 |
| PRAME | KCNH8 | 0.644426 | 3 | 0 | 3 |
| PRAME | ZBTB24 | 0.642009 | 6 | 0 | 5 |
| PRAME | SMPD4 | 0.640111 | 3 | 0 | 3 |
| PRAME | CLTC | 0.637203 | 6 | 0 | 5 |
| PRAME | CBX2 | 0.635879 | 7 | 0 | 6 |
| PRAME | B3GAT3 | 0.635164 | 6 | 0 | 4 |
| PRAME | C7orf26 | 0.631439 | 3 | 0 | 3 |
For details and further investigation, click here
