ZFAT

 

Full name: zinc finger and AT-hook domain containing Alias Symbol: KIAA1485
Type: protein-coding gene Cytoband: 8q24.22
Entrez ID: 57623 HGNC ID: HGNC:19899 Ensembl Gene: ENSG00000066827 OMIM ID: 610931
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ZFAT:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ZFAT 57623 226564_at 0.2155 0.5818
GSE26886 ZFAT 57623 226564_at 0.2492 0.0859
GSE45670 ZFAT 57623 226564_at 0.0690 0.4470
GSE53622 ZFAT 57623 49215 0.1060 0.1020
GSE53624 ZFAT 57623 30910 0.3679 0.0000
GSE63941 ZFAT 57623 226564_at 0.5247 0.1123
GSE77861 ZFAT 57623 226564_at 0.1125 0.4201
GSE97050 ZFAT 57623 A_33_P3265479 0.5311 0.1584
SRP007169 ZFAT 57623 RNAseq 0.0906 0.8589
SRP008496 ZFAT 57623 RNAseq 0.4238 0.2374
SRP064894 ZFAT 57623 RNAseq 0.2340 0.1298
SRP133303 ZFAT 57623 RNAseq 0.0933 0.4861
SRP159526 ZFAT 57623 RNAseq 0.2470 0.3262
SRP193095 ZFAT 57623 RNAseq 0.1774 0.0514
SRP219564 ZFAT 57623 RNAseq -0.0733 0.8163
TCGA ZFAT 57623 RNAseq 0.0704 0.2494

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by ZFAT expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ZFAT:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ZFAT 57623 15 1 14
GSE20123 ZFAT 57623 16 1 13
GSE43470 ZFAT 57623 23 1 19
GSE46452 ZFAT 57623 27 0 32
GSE47630 ZFAT 57623 24 0 16
GSE54993 ZFAT 57623 0 25 45
GSE54994 ZFAT 57623 39 1 13
GSE60625 ZFAT 57623 0 7 4
GSE74703 ZFAT 57623 20 0 16
GSE74704 ZFAT 57623 11 1 8
TCGA ZFAT 57623 66 2 28

Total number of gains: 241; Total number of losses: 39; Total Number of normals: 208.  

 

Somatic mutations of ZFAT:

 

Generating mutation plots.

 

Highly correlated genes for ZFAT:

 

Showing top 20/140 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ZFATTRIM110.776019303
ZFATDRG20.750293303
ZFATPARP100.714151303
ZFATZMYND150.711779303
ZFATDDX490.705957303
ZFATPLEC0.694457404
ZFATSYNGAP10.690035404
ZFATTIGD50.68719403
ZFATSHISA70.68023303
ZFATYDJC0.671732303
ZFATBLOC1S30.670043303
ZFATCHEK20.668587404
ZFATHAPLN30.666179303
ZFATNPM30.662675303
ZFATAPBA20.660997303
ZFATMEGF80.659403303
ZFATCHIT10.658316303
ZFATTMEM1820.657832303
ZFATHINFP0.657267303
ZFATTIMM500.657125404

For details and further investigation, click here