| Full name: ectonucleotide pyrophosphatase/phosphodiesterase 1 | Alias Symbol: PC-1|PCA1 | ||
| Type: protein-coding gene | Cytoband: 6q23.2 | ||
| Entrez ID: 5167 | HGNC ID: HGNC:3356 | Ensembl Gene: ENSG00000197594 | OMIM ID: 173335 |
| Drug and gene relationship at DGIdb | |||
Expression of ENPP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ENPP1 | 5167 | 205066_s_at | -1.0633 | 0.0726 | |
| GSE20347 | ENPP1 | 5167 | 205066_s_at | -0.0506 | 0.6405 | |
| GSE23400 | ENPP1 | 5167 | 205066_s_at | -0.1029 | 0.0065 | |
| GSE26886 | ENPP1 | 5167 | 205066_s_at | 0.5948 | 0.0191 | |
| GSE29001 | ENPP1 | 5167 | 205066_s_at | 0.1410 | 0.6516 | |
| GSE38129 | ENPP1 | 5167 | 205066_s_at | -0.2973 | 0.0421 | |
| GSE45670 | ENPP1 | 5167 | 205066_s_at | -1.1408 | 0.0000 | |
| GSE53622 | ENPP1 | 5167 | 112836 | -0.0628 | 0.6574 | |
| GSE53624 | ENPP1 | 5167 | 112836 | 0.1030 | 0.2340 | |
| GSE63941 | ENPP1 | 5167 | 205066_s_at | -0.7560 | 0.2976 | |
| GSE77861 | ENPP1 | 5167 | 205066_s_at | 0.0060 | 0.9729 | |
| GSE97050 | ENPP1 | 5167 | A_23_P156880 | -0.4468 | 0.2395 | |
| SRP007169 | ENPP1 | 5167 | RNAseq | 2.9695 | 0.0001 | |
| SRP008496 | ENPP1 | 5167 | RNAseq | 3.8418 | 0.0000 | |
| SRP064894 | ENPP1 | 5167 | RNAseq | -0.5057 | 0.0826 | |
| SRP133303 | ENPP1 | 5167 | RNAseq | -0.1841 | 0.6248 | |
| SRP159526 | ENPP1 | 5167 | RNAseq | -0.1686 | 0.7793 | |
| SRP193095 | ENPP1 | 5167 | RNAseq | 0.3481 | 0.2334 | |
| SRP219564 | ENPP1 | 5167 | RNAseq | -0.9053 | 0.1716 | |
| TCGA | ENPP1 | 5167 | RNAseq | -0.8667 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by ENPP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ENPP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ENPP1 | 5167 | 2 | 5 | 23 | |
| GSE20123 | ENPP1 | 5167 | 2 | 4 | 24 | |
| GSE43470 | ENPP1 | 5167 | 5 | 0 | 38 | |
| GSE46452 | ENPP1 | 5167 | 2 | 11 | 46 | |
| GSE47630 | ENPP1 | 5167 | 9 | 4 | 27 | |
| GSE54993 | ENPP1 | 5167 | 3 | 2 | 65 | |
| GSE54994 | ENPP1 | 5167 | 9 | 7 | 37 | |
| GSE60625 | ENPP1 | 5167 | 0 | 1 | 10 | |
| GSE74703 | ENPP1 | 5167 | 4 | 0 | 32 | |
| GSE74704 | ENPP1 | 5167 | 1 | 1 | 18 | |
| TCGA | ENPP1 | 5167 | 11 | 18 | 67 |
Total number of gains: 48; Total number of losses: 53; Total Number of normals: 387.
Somatic mutations of ENPP1:
Generating mutation plots.
Highly correlated genes for ENPP1:
Showing top 20/214 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ENPP1 | SYCE1L | 0.740147 | 3 | 0 | 3 |
| ENPP1 | SPRY3 | 0.739 | 3 | 0 | 3 |
| ENPP1 | IP6K3 | 0.729749 | 3 | 0 | 3 |
| ENPP1 | SCN5A | 0.70472 | 3 | 0 | 3 |
| ENPP1 | NOG | 0.700877 | 4 | 0 | 4 |
| ENPP1 | TMEM108 | 0.685064 | 5 | 0 | 4 |
| ENPP1 | ARHGEF25 | 0.681731 | 3 | 0 | 3 |
| ENPP1 | SCARF2 | 0.671123 | 3 | 0 | 3 |
| ENPP1 | TPO | 0.665729 | 4 | 0 | 3 |
| ENPP1 | KLKB1 | 0.662894 | 3 | 0 | 3 |
| ENPP1 | FGF14 | 0.658072 | 4 | 0 | 3 |
| ENPP1 | RAX | 0.652784 | 3 | 0 | 3 |
| ENPP1 | SHC3 | 0.648913 | 3 | 0 | 3 |
| ENPP1 | RNF150 | 0.642435 | 5 | 0 | 4 |
| ENPP1 | CCDC110 | 0.641533 | 3 | 0 | 3 |
| ENPP1 | WIF1 | 0.640213 | 3 | 0 | 3 |
| ENPP1 | KCNH8 | 0.639213 | 4 | 0 | 3 |
| ENPP1 | DMGDH | 0.638401 | 5 | 0 | 3 |
| ENPP1 | FAM107A | 0.637692 | 4 | 0 | 4 |
| ENPP1 | SMOC2 | 0.635837 | 5 | 0 | 4 |
For details and further investigation, click here
