| Full name: leucine rich repeat containing G protein-coupled receptor 6 | Alias Symbol: FLJ14471 | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 59352 | HGNC ID: HGNC:19719 | Ensembl Gene: ENSG00000133067 | OMIM ID: 606653 |
| Drug and gene relationship at DGIdb | |||
Expression of LGR6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LGR6 | 59352 | 227819_at | -0.7989 | 0.3296 | |
| GSE26886 | LGR6 | 59352 | 227819_at | 1.1756 | 0.0022 | |
| GSE45670 | LGR6 | 59352 | 227819_at | -0.4854 | 0.0505 | |
| GSE53622 | LGR6 | 59352 | 44160 | -0.4297 | 0.0726 | |
| GSE53624 | LGR6 | 59352 | 44160 | -0.7166 | 0.0000 | |
| GSE63941 | LGR6 | 59352 | 227819_at | 0.3690 | 0.2476 | |
| GSE77861 | LGR6 | 59352 | 227819_at | 0.5769 | 0.4666 | |
| GSE97050 | LGR6 | 59352 | A_33_P3310274 | -0.1066 | 0.6617 | |
| SRP064894 | LGR6 | 59352 | RNAseq | -1.9106 | 0.0001 | |
| SRP133303 | LGR6 | 59352 | RNAseq | -1.4184 | 0.0134 | |
| SRP159526 | LGR6 | 59352 | RNAseq | -0.9521 | 0.0925 | |
| SRP219564 | LGR6 | 59352 | RNAseq | -0.6117 | 0.4430 | |
| TCGA | LGR6 | 59352 | RNAseq | -0.0278 | 0.9388 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by LGR6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LGR6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LGR6 | 59352 | 11 | 0 | 19 | |
| GSE20123 | LGR6 | 59352 | 11 | 0 | 19 | |
| GSE43470 | LGR6 | 59352 | 6 | 0 | 37 | |
| GSE46452 | LGR6 | 59352 | 3 | 1 | 55 | |
| GSE47630 | LGR6 | 59352 | 14 | 0 | 26 | |
| GSE54993 | LGR6 | 59352 | 0 | 6 | 64 | |
| GSE54994 | LGR6 | 59352 | 15 | 0 | 38 | |
| GSE60625 | LGR6 | 59352 | 0 | 0 | 11 | |
| GSE74703 | LGR6 | 59352 | 6 | 0 | 30 | |
| GSE74704 | LGR6 | 59352 | 5 | 0 | 15 | |
| TCGA | LGR6 | 59352 | 43 | 4 | 49 |
Total number of gains: 114; Total number of losses: 11; Total Number of normals: 363.
Somatic mutations of LGR6:
Generating mutation plots.
Highly correlated genes for LGR6:
Showing top 20/21 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LGR6 | KCNH8 | 0.732881 | 4 | 0 | 4 |
| LGR6 | CHGB | 0.732187 | 3 | 0 | 3 |
| LGR6 | ARID3A | 0.710557 | 3 | 0 | 3 |
| LGR6 | TBX3 | 0.698326 | 3 | 0 | 3 |
| LGR6 | BRSK1 | 0.69548 | 3 | 0 | 3 |
| LGR6 | CLTCL1 | 0.681282 | 4 | 0 | 3 |
| LGR6 | MOGAT3 | 0.676799 | 3 | 0 | 3 |
| LGR6 | GARNL3 | 0.674077 | 3 | 0 | 3 |
| LGR6 | MANBA | 0.670129 | 3 | 0 | 3 |
| LGR6 | CHST10 | 0.6521 | 4 | 0 | 3 |
| LGR6 | ATP8B3 | 0.647901 | 3 | 0 | 3 |
| LGR6 | BCAT1 | 0.632969 | 3 | 0 | 3 |
| LGR6 | SHC2 | 0.619108 | 4 | 0 | 3 |
| LGR6 | FGF19 | 0.595802 | 5 | 0 | 3 |
| LGR6 | NKD2 | 0.574559 | 5 | 0 | 3 |
| LGR6 | TMEM163 | 0.569125 | 5 | 0 | 4 |
| LGR6 | BCL11B | 0.56839 | 3 | 0 | 3 |
| LGR6 | WIF1 | 0.553875 | 6 | 0 | 3 |
| LGR6 | KRT74 | 0.544246 | 5 | 0 | 3 |
| LGR6 | VPS51 | 0.523918 | 4 | 0 | 3 |
For details and further investigation, click here
