| Full name: lysine demethylase 8 | Alias Symbol: FLJ13798 | ||
| Type: protein-coding gene | Cytoband: 16p12.1 | ||
| Entrez ID: 79831 | HGNC ID: HGNC:25840 | Ensembl Gene: ENSG00000155666 | OMIM ID: 611917 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of KDM8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KDM8 | 79831 | 220070_at | -0.0090 | 0.9728 | |
| GSE20347 | KDM8 | 79831 | 220070_at | -0.0819 | 0.2527 | |
| GSE23400 | KDM8 | 79831 | 220070_at | -0.0758 | 0.0063 | |
| GSE26886 | KDM8 | 79831 | 220070_at | -0.1388 | 0.2534 | |
| GSE29001 | KDM8 | 79831 | 220070_at | -0.1220 | 0.4229 | |
| GSE38129 | KDM8 | 79831 | 220070_at | -0.1352 | 0.0229 | |
| GSE45670 | KDM8 | 79831 | 241045_at | -0.1301 | 0.3850 | |
| GSE53622 | KDM8 | 79831 | 59237 | 0.0914 | 0.2884 | |
| GSE53624 | KDM8 | 79831 | 59237 | -0.1619 | 0.0309 | |
| GSE63941 | KDM8 | 79831 | 241045_at | -0.1135 | 0.4948 | |
| GSE77861 | KDM8 | 79831 | 241045_at | -0.1654 | 0.3042 | |
| SRP064894 | KDM8 | 79831 | RNAseq | 0.2870 | 0.1627 | |
| SRP133303 | KDM8 | 79831 | RNAseq | -0.3772 | 0.0577 | |
| SRP159526 | KDM8 | 79831 | RNAseq | -0.2562 | 0.5639 | |
| SRP193095 | KDM8 | 79831 | RNAseq | -0.3832 | 0.0203 | |
| SRP219564 | KDM8 | 79831 | RNAseq | 0.4450 | 0.3159 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KDM8 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of KDM8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KDM8 | 79831 | 4 | 5 | 21 | |
| GSE20123 | KDM8 | 79831 | 4 | 4 | 22 | |
| GSE43470 | KDM8 | 79831 | 4 | 3 | 36 | |
| GSE46452 | KDM8 | 79831 | 38 | 1 | 20 | |
| GSE47630 | KDM8 | 79831 | 12 | 6 | 22 | |
| GSE54993 | KDM8 | 79831 | 3 | 5 | 62 | |
| GSE54994 | KDM8 | 79831 | 4 | 9 | 40 | |
| GSE60625 | KDM8 | 79831 | 4 | 0 | 7 | |
| GSE74703 | KDM8 | 79831 | 4 | 2 | 30 | |
| GSE74704 | KDM8 | 79831 | 2 | 2 | 16 | |
| TCGA | KDM8 | 79831 | 19 | 12 | 65 |
Total number of gains: 98; Total number of losses: 49; Total Number of normals: 341.
Somatic mutations of KDM8:
Generating mutation plots.
Highly correlated genes for KDM8:
Showing top 20/412 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KDM8 | DEFB108B | 0.761037 | 3 | 0 | 3 |
| KDM8 | KIRREL2 | 0.753068 | 3 | 0 | 3 |
| KDM8 | SIM1 | 0.744888 | 3 | 0 | 3 |
| KDM8 | OTUD7A | 0.744467 | 3 | 0 | 3 |
| KDM8 | F2RL3 | 0.732467 | 4 | 0 | 4 |
| KDM8 | BRF1 | 0.730567 | 4 | 0 | 4 |
| KDM8 | CCDC106 | 0.730014 | 3 | 0 | 3 |
| KDM8 | TATDN3 | 0.715473 | 3 | 0 | 3 |
| KDM8 | CECR9 | 0.708265 | 4 | 0 | 4 |
| KDM8 | OR2H1 | 0.707398 | 4 | 0 | 4 |
| KDM8 | SEZ6 | 0.701913 | 3 | 0 | 3 |
| KDM8 | CCIN | 0.696225 | 5 | 0 | 5 |
| KDM8 | PRR7-AS1 | 0.691965 | 3 | 0 | 3 |
| KDM8 | ZGLP1 | 0.688273 | 3 | 0 | 3 |
| KDM8 | LIN28A | 0.686822 | 3 | 0 | 3 |
| KDM8 | CASC18 | 0.685662 | 3 | 0 | 3 |
| KDM8 | TTLL9 | 0.683159 | 3 | 0 | 3 |
| KDM8 | SLC22A31 | 0.66858 | 5 | 0 | 4 |
| KDM8 | KRTAP4-8 | 0.664479 | 4 | 0 | 3 |
| KDM8 | SPACA3 | 0.662981 | 4 | 0 | 4 |
For details and further investigation, click here
