| Full name: seizure related 6 homolog | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q11.2 | ||
| Entrez ID: 124925 | HGNC ID: HGNC:15955 | Ensembl Gene: ENSG00000063015 | OMIM ID: 616666 |
| Drug and gene relationship at DGIdb | |||
Expression of SEZ6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEZ6 | 124925 | 243430_at | -0.0862 | 0.7429 | |
| GSE26886 | SEZ6 | 124925 | 243430_at | 0.0752 | 0.5093 | |
| GSE45670 | SEZ6 | 124925 | 243430_at | -0.0134 | 0.8970 | |
| GSE53622 | SEZ6 | 124925 | 36136 | 0.0771 | 0.4680 | |
| GSE53624 | SEZ6 | 124925 | 36136 | 0.0072 | 0.9524 | |
| GSE63941 | SEZ6 | 124925 | 243430_at | 0.3245 | 0.0404 | |
| GSE77861 | SEZ6 | 124925 | 243430_at | -0.0904 | 0.2075 | |
| GSE97050 | SEZ6 | 124925 | A_33_P3374076 | -0.0382 | 0.8874 | |
| SRP133303 | SEZ6 | 124925 | RNAseq | -0.5620 | 0.0307 | |
| TCGA | SEZ6 | 124925 | RNAseq | -2.2950 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SEZ6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEZ6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEZ6 | 124925 | 10 | 1 | 19 | |
| GSE20123 | SEZ6 | 124925 | 10 | 1 | 19 | |
| GSE43470 | SEZ6 | 124925 | 0 | 1 | 42 | |
| GSE46452 | SEZ6 | 124925 | 33 | 1 | 25 | |
| GSE47630 | SEZ6 | 124925 | 7 | 1 | 32 | |
| GSE54993 | SEZ6 | 124925 | 2 | 3 | 65 | |
| GSE54994 | SEZ6 | 124925 | 7 | 6 | 40 | |
| GSE60625 | SEZ6 | 124925 | 4 | 0 | 7 | |
| GSE74703 | SEZ6 | 124925 | 0 | 1 | 35 | |
| GSE74704 | SEZ6 | 124925 | 7 | 1 | 12 | |
| TCGA | SEZ6 | 124925 | 21 | 10 | 65 |
Total number of gains: 101; Total number of losses: 26; Total Number of normals: 361.
Somatic mutations of SEZ6:
Generating mutation plots.
Highly correlated genes for SEZ6:
Showing top 20/465 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEZ6 | PTAFR | 0.767747 | 3 | 0 | 3 |
| SEZ6 | RAPGEF3 | 0.752512 | 4 | 0 | 4 |
| SEZ6 | C9orf153 | 0.734433 | 3 | 0 | 3 |
| SEZ6 | GRIK4 | 0.734192 | 3 | 0 | 3 |
| SEZ6 | RBAKDN | 0.725338 | 3 | 0 | 3 |
| SEZ6 | STRC | 0.722029 | 3 | 0 | 3 |
| SEZ6 | EP300-AS1 | 0.721613 | 3 | 0 | 3 |
| SEZ6 | GHSR | 0.721251 | 3 | 0 | 3 |
| SEZ6 | LINC00924 | 0.71741 | 3 | 0 | 3 |
| SEZ6 | SPEG | 0.713512 | 3 | 0 | 3 |
| SEZ6 | SPANXN4 | 0.707502 | 3 | 0 | 3 |
| SEZ6 | PLA2G2C | 0.707071 | 3 | 0 | 3 |
| SEZ6 | KDM8 | 0.701913 | 3 | 0 | 3 |
| SEZ6 | CATSPERG | 0.70071 | 4 | 0 | 4 |
| SEZ6 | MROH7 | 0.698087 | 3 | 0 | 3 |
| SEZ6 | SERHL2 | 0.697775 | 3 | 0 | 3 |
| SEZ6 | KRTAP10-3 | 0.695855 | 4 | 0 | 4 |
| SEZ6 | LHX9 | 0.695558 | 4 | 0 | 4 |
| SEZ6 | CELF5 | 0.694235 | 3 | 0 | 3 |
| SEZ6 | SIM1 | 0.69205 | 4 | 0 | 4 |
For details and further investigation, click here
