| Full name: keratin associated protein 4-8 | Alias Symbol: KAP4.8 | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 728224 | HGNC ID: HGNC:17230 | Ensembl Gene: ENSG00000204880 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of KRTAP4-8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KRTAP4-8 | 728224 | 234631_at | -0.0630 | 0.7973 | |
| GSE26886 | KRTAP4-8 | 728224 | 234631_at | -0.3664 | 0.0179 | |
| GSE45670 | KRTAP4-8 | 728224 | 234631_at | -0.1092 | 0.4665 | |
| GSE53622 | KRTAP4-8 | 728224 | 79076 | 0.1260 | 0.2702 | |
| GSE53624 | KRTAP4-8 | 728224 | 79076 | -0.2357 | 0.0379 | |
| GSE63941 | KRTAP4-8 | 728224 | 234631_at | 0.0913 | 0.4955 | |
| GSE77861 | KRTAP4-8 | 728224 | 234631_at | -0.1332 | 0.3787 | |
| GSE97050 | KRTAP4-8 | 728224 | A_33_P3209615 | -0.0679 | 0.7774 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KRTAP4-8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KRTAP4-8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KRTAP4-8 | 728224 | 7 | 1 | 22 | |
| GSE20123 | KRTAP4-8 | 728224 | 7 | 1 | 22 | |
| GSE43470 | KRTAP4-8 | 728224 | 1 | 2 | 40 | |
| GSE46452 | KRTAP4-8 | 728224 | 34 | 0 | 25 | |
| GSE47630 | KRTAP4-8 | 728224 | 8 | 1 | 31 | |
| GSE54993 | KRTAP4-8 | 728224 | 3 | 4 | 63 | |
| GSE54994 | KRTAP4-8 | 728224 | 8 | 5 | 40 | |
| GSE60625 | KRTAP4-8 | 728224 | 4 | 0 | 7 | |
| GSE74703 | KRTAP4-8 | 728224 | 1 | 1 | 34 | |
| GSE74704 | KRTAP4-8 | 728224 | 4 | 1 | 15 |
Total number of gains: 77; Total number of losses: 16; Total Number of normals: 299.
Somatic mutations of KRTAP4-8:
Generating mutation plots.
Highly correlated genes for KRTAP4-8:
Showing top 20/665 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KRTAP4-8 | KRTAP10-12 | 0.877013 | 3 | 0 | 3 |
| KRTAP4-8 | YY2 | 0.855325 | 3 | 0 | 3 |
| KRTAP4-8 | SLC22A12 | 0.841693 | 4 | 0 | 4 |
| KRTAP4-8 | STRC | 0.841127 | 3 | 0 | 3 |
| KRTAP4-8 | PLA2G2C | 0.839222 | 3 | 0 | 3 |
| KRTAP4-8 | OR2T27 | 0.834854 | 3 | 0 | 3 |
| KRTAP4-8 | DCDC1 | 0.831633 | 3 | 0 | 3 |
| KRTAP4-8 | PAX6 | 0.828935 | 3 | 0 | 3 |
| KRTAP4-8 | NRSN1 | 0.822907 | 3 | 0 | 3 |
| KRTAP4-8 | CELF5 | 0.816114 | 3 | 0 | 3 |
| KRTAP4-8 | OTOG | 0.814002 | 3 | 0 | 3 |
| KRTAP4-8 | OR10AD1 | 0.813286 | 3 | 0 | 3 |
| KRTAP4-8 | PRSS38 | 0.811137 | 3 | 0 | 3 |
| KRTAP4-8 | OR2T1 | 0.799784 | 3 | 0 | 3 |
| KRTAP4-8 | FZD9 | 0.798165 | 3 | 0 | 3 |
| KRTAP4-8 | CIB3 | 0.797976 | 4 | 0 | 4 |
| KRTAP4-8 | INSC | 0.797667 | 3 | 0 | 3 |
| KRTAP4-8 | ZNF763 | 0.796312 | 3 | 0 | 3 |
| KRTAP4-8 | RBM43 | 0.796069 | 3 | 0 | 3 |
| KRTAP4-8 | KRTAP6-1 | 0.789981 | 3 | 0 | 3 |
For details and further investigation, click here
