| Full name: BRF1 RNA polymerase III transcription initiation factor subunit | Alias Symbol: TFIIIB90|BRF|hBRF | ||
| Type: protein-coding gene | Cytoband: 14q32.33 | ||
| Entrez ID: 2972 | HGNC ID: HGNC:11551 | Ensembl Gene: ENSG00000185024 | OMIM ID: 604902 |
| Drug and gene relationship at DGIdb | |||
Expression of BRF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BRF1 | 2972 | 203754_s_at | 0.5525 | 0.0982 | |
| GSE20347 | BRF1 | 2972 | 203754_s_at | 0.3541 | 0.0007 | |
| GSE23400 | BRF1 | 2972 | 203754_s_at | 0.0771 | 0.0911 | |
| GSE26886 | BRF1 | 2972 | 203754_s_at | 0.8466 | 0.0000 | |
| GSE29001 | BRF1 | 2972 | 203754_s_at | 0.0579 | 0.7754 | |
| GSE38129 | BRF1 | 2972 | 203754_s_at | 0.2807 | 0.0012 | |
| GSE45670 | BRF1 | 2972 | 203754_s_at | 0.2719 | 0.0260 | |
| GSE53622 | BRF1 | 2972 | 72629 | 0.2669 | 0.0001 | |
| GSE53624 | BRF1 | 2972 | 72629 | 0.0380 | 0.7231 | |
| GSE63941 | BRF1 | 2972 | 203754_s_at | 0.3606 | 0.1995 | |
| GSE77861 | BRF1 | 2972 | 215676_at | -0.1037 | 0.4361 | |
| GSE97050 | BRF1 | 2972 | A_33_P3363016 | 0.2017 | 0.3818 | |
| SRP007169 | BRF1 | 2972 | RNAseq | 0.5388 | 0.2483 | |
| SRP008496 | BRF1 | 2972 | RNAseq | 0.2640 | 0.5032 | |
| SRP064894 | BRF1 | 2972 | RNAseq | 0.7346 | 0.0003 | |
| SRP133303 | BRF1 | 2972 | RNAseq | 0.2760 | 0.0494 | |
| SRP159526 | BRF1 | 2972 | RNAseq | 1.0013 | 0.0333 | |
| SRP193095 | BRF1 | 2972 | RNAseq | 0.5651 | 0.0000 | |
| SRP219564 | BRF1 | 2972 | RNAseq | 0.5002 | 0.0866 | |
| TCGA | BRF1 | 2972 | RNAseq | 0.0069 | 0.8924 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by BRF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BRF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BRF1 | 2972 | 11 | 3 | 16 | |
| GSE20123 | BRF1 | 2972 | 10 | 2 | 18 | |
| GSE43470 | BRF1 | 2972 | 5 | 3 | 35 | |
| GSE46452 | BRF1 | 2972 | 18 | 4 | 37 | |
| GSE47630 | BRF1 | 2972 | 11 | 8 | 21 | |
| GSE54993 | BRF1 | 2972 | 4 | 10 | 56 | |
| GSE54994 | BRF1 | 2972 | 21 | 4 | 28 | |
| GSE60625 | BRF1 | 2972 | 0 | 2 | 9 | |
| GSE74703 | BRF1 | 2972 | 4 | 3 | 29 | |
| GSE74704 | BRF1 | 2972 | 5 | 2 | 13 | |
| TCGA | BRF1 | 2972 | 32 | 17 | 47 |
Total number of gains: 121; Total number of losses: 58; Total Number of normals: 309.
Somatic mutations of BRF1:
Generating mutation plots.
Highly correlated genes for BRF1:
Showing top 20/667 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BRF1 | C9orf153 | 0.750653 | 3 | 0 | 3 |
| BRF1 | PNPLA7 | 0.746591 | 3 | 0 | 3 |
| BRF1 | ZNF579 | 0.73584 | 3 | 0 | 3 |
| BRF1 | KDM8 | 0.730567 | 4 | 0 | 4 |
| BRF1 | STRC | 0.722638 | 3 | 0 | 3 |
| BRF1 | ANKRD13B | 0.719895 | 4 | 0 | 4 |
| BRF1 | SYT1 | 0.70482 | 4 | 0 | 4 |
| BRF1 | GHSR | 0.700392 | 4 | 0 | 4 |
| BRF1 | TTLL9 | 0.699848 | 4 | 0 | 3 |
| BRF1 | HES7 | 0.696833 | 3 | 0 | 3 |
| BRF1 | ZNF683 | 0.696174 | 5 | 0 | 5 |
| BRF1 | MRGPRG | 0.686242 | 3 | 0 | 3 |
| BRF1 | EFNA3 | 0.684117 | 4 | 0 | 4 |
| BRF1 | LIPE-AS1 | 0.680408 | 3 | 0 | 3 |
| BRF1 | CIB3 | 0.68029 | 4 | 0 | 3 |
| BRF1 | OR11A1 | 0.679215 | 3 | 0 | 3 |
| BRF1 | CD70 | 0.679126 | 4 | 0 | 4 |
| BRF1 | CCDC106 | 0.678469 | 3 | 0 | 3 |
| BRF1 | RIMS4 | 0.675846 | 6 | 0 | 5 |
| BRF1 | LBX2 | 0.67572 | 3 | 0 | 3 |
For details and further investigation, click here
