| Full name: SIM bHLH transcription factor 1 | Alias Symbol: bHLHe14 | ||
| Type: protein-coding gene | Cytoband: 6q16.3 | ||
| Entrez ID: 6492 | HGNC ID: HGNC:10882 | Ensembl Gene: ENSG00000112246 | OMIM ID: 603128 |
| Drug and gene relationship at DGIdb | |||
Expression of SIM1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIM1 | 6492 | 1552796_a_at | 0.0064 | 0.9892 | |
| GSE20347 | SIM1 | 6492 | 206876_at | -0.0308 | 0.6737 | |
| GSE23400 | SIM1 | 6492 | 206876_at | -0.0645 | 0.0348 | |
| GSE26886 | SIM1 | 6492 | 206876_at | 0.0916 | 0.4649 | |
| GSE29001 | SIM1 | 6492 | 206876_at | -0.0616 | 0.6770 | |
| GSE38129 | SIM1 | 6492 | 206876_at | -0.1155 | 0.0792 | |
| GSE45670 | SIM1 | 6492 | 1552796_a_at | 0.1072 | 0.1541 | |
| GSE53622 | SIM1 | 6492 | 78542 | 0.1527 | 0.1295 | |
| GSE53624 | SIM1 | 6492 | 78542 | 0.0691 | 0.6171 | |
| GSE63941 | SIM1 | 6492 | 1552796_a_at | 0.1493 | 0.1776 | |
| GSE77861 | SIM1 | 6492 | 206876_at | 0.0732 | 0.5791 | |
| GSE97050 | SIM1 | 6492 | A_23_P214743 | 0.0011 | 0.9971 | |
| TCGA | SIM1 | 6492 | RNAseq | 2.7894 | 0.0623 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SIM1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIM1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIM1 | 6492 | 1 | 3 | 26 | |
| GSE20123 | SIM1 | 6492 | 1 | 2 | 27 | |
| GSE43470 | SIM1 | 6492 | 3 | 0 | 40 | |
| GSE46452 | SIM1 | 6492 | 2 | 11 | 46 | |
| GSE47630 | SIM1 | 6492 | 8 | 6 | 26 | |
| GSE54993 | SIM1 | 6492 | 3 | 2 | 65 | |
| GSE54994 | SIM1 | 6492 | 8 | 8 | 37 | |
| GSE60625 | SIM1 | 6492 | 0 | 1 | 10 | |
| GSE74703 | SIM1 | 6492 | 2 | 0 | 34 | |
| GSE74704 | SIM1 | 6492 | 0 | 0 | 20 | |
| TCGA | SIM1 | 6492 | 7 | 23 | 66 |
Total number of gains: 35; Total number of losses: 56; Total Number of normals: 397.
Somatic mutations of SIM1:
Generating mutation plots.
Highly correlated genes for SIM1:
Showing top 20/695 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIM1 | OR2T27 | 0.891879 | 3 | 0 | 3 |
| SIM1 | YY2 | 0.876721 | 3 | 0 | 3 |
| SIM1 | PLA2G2C | 0.859754 | 3 | 0 | 3 |
| SIM1 | DCDC1 | 0.850853 | 3 | 0 | 3 |
| SIM1 | OR10AD1 | 0.844148 | 3 | 0 | 3 |
| SIM1 | RNF180 | 0.839147 | 3 | 0 | 3 |
| SIM1 | KRTAP10-12 | 0.828153 | 3 | 0 | 3 |
| SIM1 | OR2T1 | 0.827411 | 3 | 0 | 3 |
| SIM1 | STRC | 0.823555 | 3 | 0 | 3 |
| SIM1 | OR2A5 | 0.819854 | 3 | 0 | 3 |
| SIM1 | BBC3 | 0.815426 | 3 | 0 | 3 |
| SIM1 | OTOG | 0.814172 | 3 | 0 | 3 |
| SIM1 | PRSS38 | 0.811641 | 3 | 0 | 3 |
| SIM1 | TMEM105 | 0.800072 | 4 | 0 | 4 |
| SIM1 | MYO15B | 0.796086 | 3 | 0 | 3 |
| SIM1 | C1QL2 | 0.780968 | 3 | 0 | 3 |
| SIM1 | RBM28 | 0.772867 | 3 | 0 | 3 |
| SIM1 | GDF7 | 0.77286 | 3 | 0 | 3 |
| SIM1 | DEFB121 | 0.772352 | 4 | 0 | 3 |
| SIM1 | DEFB108B | 0.771047 | 3 | 0 | 3 |
For details and further investigation, click here
