| Full name: lin-28 homolog A | Alias Symbol: LIN-28|FLJ12457|ZCCHC1|CSDD1 | ||
| Type: protein-coding gene | Cytoband: 1p36.11 | ||
| Entrez ID: 79727 | HGNC ID: HGNC:15986 | Ensembl Gene: ENSG00000131914 | OMIM ID: 611043 |
| Drug and gene relationship at DGIdb | |||
Expression of LIN28A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LIN28A | 79727 | 219823_at | 0.1860 | 0.3900 | |
| GSE20347 | LIN28A | 79727 | 219823_at | 0.1272 | 0.0502 | |
| GSE23400 | LIN28A | 79727 | 219823_at | 0.0167 | 0.4182 | |
| GSE26886 | LIN28A | 79727 | 219823_at | 0.1717 | 0.0543 | |
| GSE29001 | LIN28A | 79727 | 219823_at | 0.0794 | 0.6155 | |
| GSE38129 | LIN28A | 79727 | 219823_at | 0.0606 | 0.3964 | |
| GSE45670 | LIN28A | 79727 | 219823_at | 0.0463 | 0.5601 | |
| GSE53622 | LIN28A | 79727 | 65136 | 0.3299 | 0.0050 | |
| GSE53624 | LIN28A | 79727 | 65136 | 0.2610 | 0.0525 | |
| GSE63941 | LIN28A | 79727 | 219823_at | -0.0234 | 0.8901 | |
| GSE77861 | LIN28A | 79727 | 219823_at | 0.0044 | 0.9666 | |
| SRP133303 | LIN28A | 79727 | RNAseq | 0.1537 | 0.3243 | |
| SRP193095 | LIN28A | 79727 | RNAseq | 0.1352 | 0.4289 | |
| TCGA | LIN28A | 79727 | RNAseq | 1.3518 | 0.2221 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LIN28A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LIN28A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LIN28A | 79727 | 0 | 6 | 24 | |
| GSE20123 | LIN28A | 79727 | 0 | 5 | 25 | |
| GSE43470 | LIN28A | 79727 | 2 | 6 | 35 | |
| GSE46452 | LIN28A | 79727 | 5 | 1 | 53 | |
| GSE47630 | LIN28A | 79727 | 8 | 3 | 29 | |
| GSE54993 | LIN28A | 79727 | 2 | 1 | 67 | |
| GSE54994 | LIN28A | 79727 | 10 | 4 | 39 | |
| GSE60625 | LIN28A | 79727 | 0 | 0 | 11 | |
| GSE74703 | LIN28A | 79727 | 1 | 4 | 31 | |
| GSE74704 | LIN28A | 79727 | 0 | 0 | 20 | |
| TCGA | LIN28A | 79727 | 9 | 24 | 63 |
Total number of gains: 37; Total number of losses: 54; Total Number of normals: 397.
Somatic mutations of LIN28A:
Generating mutation plots.
Highly correlated genes for LIN28A:
Showing top 20/366 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LIN28A | APOF | 0.758 | 3 | 0 | 3 |
| LIN28A | C11orf72 | 0.756617 | 3 | 0 | 3 |
| LIN28A | TMEM235 | 0.710542 | 3 | 0 | 3 |
| LIN28A | TMPO-AS1 | 0.702225 | 3 | 0 | 3 |
| LIN28A | LIPG | 0.699424 | 3 | 0 | 3 |
| LIN28A | FOXN2 | 0.695072 | 3 | 0 | 3 |
| LIN28A | DLGAP2-AS1 | 0.688995 | 3 | 0 | 3 |
| LIN28A | KDM8 | 0.686822 | 3 | 0 | 3 |
| LIN28A | SIRPB1 | 0.679974 | 6 | 0 | 5 |
| LIN28A | LINC01281 | 0.677823 | 4 | 0 | 3 |
| LIN28A | ZC3H18 | 0.676627 | 3 | 0 | 3 |
| LIN28A | NCDN | 0.671955 | 3 | 0 | 3 |
| LIN28A | SLAMF9 | 0.670894 | 4 | 0 | 4 |
| LIN28A | MSX1 | 0.670034 | 3 | 0 | 3 |
| LIN28A | CDH24 | 0.669517 | 4 | 0 | 3 |
| LIN28A | C5orf17 | 0.663625 | 3 | 0 | 3 |
| LIN28A | XRCC2 | 0.652207 | 5 | 0 | 4 |
| LIN28A | VWA5B1 | 0.649157 | 4 | 0 | 3 |
| LIN28A | GTSE1 | 0.645812 | 5 | 0 | 4 |
| LIN28A | NTNG2 | 0.645265 | 4 | 0 | 4 |
For details and further investigation, click here
