| Full name: X-ray repair cross complementing 2 | Alias Symbol: FANCU | ||
| Type: protein-coding gene | Cytoband: 7q36.1 | ||
| Entrez ID: 7516 | HGNC ID: HGNC:12829 | Ensembl Gene: ENSG00000196584 | OMIM ID: 600375 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of XRCC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | XRCC2 | 7516 | 207598_x_at | 0.4568 | 0.4954 | |
| GSE20347 | XRCC2 | 7516 | 207598_x_at | 0.4874 | 0.0330 | |
| GSE23400 | XRCC2 | 7516 | 207598_x_at | 0.1992 | 0.0004 | |
| GSE26886 | XRCC2 | 7516 | 207598_x_at | 0.2900 | 0.2040 | |
| GSE29001 | XRCC2 | 7516 | 207598_x_at | 0.4797 | 0.0398 | |
| GSE38129 | XRCC2 | 7516 | 207598_x_at | 0.3045 | 0.2597 | |
| GSE45670 | XRCC2 | 7516 | 207598_x_at | 0.5192 | 0.0015 | |
| GSE53622 | XRCC2 | 7516 | 15893 | 0.8539 | 0.0000 | |
| GSE53624 | XRCC2 | 7516 | 15893 | 0.6482 | 0.0000 | |
| GSE63941 | XRCC2 | 7516 | 207598_x_at | 0.3054 | 0.0967 | |
| GSE77861 | XRCC2 | 7516 | 207598_x_at | 0.5009 | 0.0509 | |
| GSE97050 | XRCC2 | 7516 | A_33_P3241190 | 0.1983 | 0.5241 | |
| SRP007169 | XRCC2 | 7516 | RNAseq | 3.0839 | 0.0000 | |
| SRP008496 | XRCC2 | 7516 | RNAseq | 2.8876 | 0.0000 | |
| SRP064894 | XRCC2 | 7516 | RNAseq | 0.9543 | 0.0015 | |
| SRP133303 | XRCC2 | 7516 | RNAseq | 0.6845 | 0.0000 | |
| SRP159526 | XRCC2 | 7516 | RNAseq | 1.6702 | 0.0000 | |
| SRP193095 | XRCC2 | 7516 | RNAseq | 0.7047 | 0.0000 | |
| SRP219564 | XRCC2 | 7516 | RNAseq | 0.8611 | 0.0414 | |
| TCGA | XRCC2 | 7516 | RNAseq | 1.2916 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by XRCC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of XRCC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | XRCC2 | 7516 | 2 | 4 | 24 | |
| GSE20123 | XRCC2 | 7516 | 2 | 4 | 24 | |
| GSE43470 | XRCC2 | 7516 | 3 | 4 | 36 | |
| GSE46452 | XRCC2 | 7516 | 7 | 2 | 50 | |
| GSE47630 | XRCC2 | 7516 | 6 | 9 | 25 | |
| GSE54993 | XRCC2 | 7516 | 3 | 3 | 64 | |
| GSE54994 | XRCC2 | 7516 | 6 | 8 | 39 | |
| GSE60625 | XRCC2 | 7516 | 0 | 0 | 11 | |
| GSE74703 | XRCC2 | 7516 | 2 | 4 | 30 | |
| GSE74704 | XRCC2 | 7516 | 1 | 4 | 15 | |
| TCGA | XRCC2 | 7516 | 26 | 27 | 43 |
Total number of gains: 58; Total number of losses: 69; Total Number of normals: 361.
Somatic mutations of XRCC2:
Generating mutation plots.
Highly correlated genes for XRCC2:
Showing top 20/353 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| XRCC2 | CCDC142 | 0.843153 | 3 | 0 | 3 |
| XRCC2 | C9orf153 | 0.821248 | 3 | 0 | 3 |
| XRCC2 | SYCN | 0.820729 | 3 | 0 | 3 |
| XRCC2 | CMBL | 0.820417 | 4 | 0 | 4 |
| XRCC2 | ZNF611 | 0.814862 | 8 | 0 | 8 |
| XRCC2 | DCDC1 | 0.792346 | 3 | 0 | 3 |
| XRCC2 | TMEM235 | 0.783596 | 3 | 0 | 3 |
| XRCC2 | YY2 | 0.777773 | 3 | 0 | 3 |
| XRCC2 | BCYRN1 | 0.777483 | 3 | 0 | 3 |
| XRCC2 | MS4A18 | 0.775607 | 3 | 0 | 3 |
| XRCC2 | SLC10A1 | 0.775584 | 3 | 0 | 3 |
| XRCC2 | STRC | 0.775521 | 3 | 0 | 3 |
| XRCC2 | KRTAP10-12 | 0.773151 | 3 | 0 | 3 |
| XRCC2 | TAS2R31 | 0.764867 | 3 | 0 | 3 |
| XRCC2 | ARHGEF1 | 0.763606 | 5 | 0 | 5 |
| XRCC2 | FUT8-AS1 | 0.760936 | 4 | 0 | 4 |
| XRCC2 | YRDC | 0.760267 | 3 | 0 | 3 |
| XRCC2 | LBX2 | 0.759859 | 3 | 0 | 3 |
| XRCC2 | GCM2 | 0.757625 | 4 | 0 | 4 |
| XRCC2 | TATDN3 | 0.755586 | 3 | 0 | 3 |
For details and further investigation, click here
