| Full name: lysosomal trafficking regulator | Alias Symbol: CHS | ||
| Type: protein-coding gene | Cytoband: 1q42.3 | ||
| Entrez ID: 1130 | HGNC ID: HGNC:1968 | Ensembl Gene: ENSG00000143669 | OMIM ID: 606897 |
| Drug and gene relationship at DGIdb | |||
Expression of LYST:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LYST | 1130 | 203518_at | 0.0119 | 0.9866 | |
| GSE20347 | LYST | 1130 | 210943_s_at | -0.0044 | 0.9858 | |
| GSE23400 | LYST | 1130 | 210943_s_at | -0.1022 | 0.0367 | |
| GSE26886 | LYST | 1130 | 203518_at | -0.5832 | 0.1503 | |
| GSE29001 | LYST | 1130 | 210943_s_at | 0.0662 | 0.8905 | |
| GSE38129 | LYST | 1130 | 203518_at | -0.3712 | 0.0778 | |
| GSE45670 | LYST | 1130 | 203518_at | -0.1747 | 0.3507 | |
| GSE53622 | LYST | 1130 | 67604 | -0.0565 | 0.5029 | |
| GSE53624 | LYST | 1130 | 67604 | -0.0079 | 0.9268 | |
| GSE63941 | LYST | 1130 | 203518_at | -1.1984 | 0.1090 | |
| GSE77861 | LYST | 1130 | 203518_at | 0.5245 | 0.1219 | |
| GSE97050 | LYST | 1130 | A_23_P354074 | -0.2527 | 0.3168 | |
| SRP007169 | LYST | 1130 | RNAseq | 0.1385 | 0.6504 | |
| SRP008496 | LYST | 1130 | RNAseq | 0.4010 | 0.0571 | |
| SRP064894 | LYST | 1130 | RNAseq | -0.2776 | 0.2668 | |
| SRP133303 | LYST | 1130 | RNAseq | -0.0366 | 0.7854 | |
| SRP159526 | LYST | 1130 | RNAseq | 0.0228 | 0.9596 | |
| SRP193095 | LYST | 1130 | RNAseq | -0.0204 | 0.8679 | |
| SRP219564 | LYST | 1130 | RNAseq | -0.0195 | 0.9648 | |
| TCGA | LYST | 1130 | RNAseq | -0.1166 | 0.1154 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LYST expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LYST:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LYST | 1130 | 10 | 0 | 20 | |
| GSE20123 | LYST | 1130 | 11 | 0 | 19 | |
| GSE43470 | LYST | 1130 | 9 | 1 | 33 | |
| GSE46452 | LYST | 1130 | 4 | 2 | 53 | |
| GSE47630 | LYST | 1130 | 15 | 0 | 25 | |
| GSE54993 | LYST | 1130 | 0 | 6 | 64 | |
| GSE54994 | LYST | 1130 | 16 | 0 | 37 | |
| GSE60625 | LYST | 1130 | 0 | 0 | 11 | |
| GSE74703 | LYST | 1130 | 9 | 1 | 26 | |
| GSE74704 | LYST | 1130 | 5 | 0 | 15 | |
| TCGA | LYST | 1130 | 43 | 4 | 49 |
Total number of gains: 122; Total number of losses: 14; Total Number of normals: 352.
Somatic mutations of LYST:
Generating mutation plots.
Highly correlated genes for LYST:
Showing top 20/207 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LYST | LYPLAL1 | 0.807233 | 3 | 0 | 3 |
| LYST | AGGF1 | 0.777343 | 3 | 0 | 3 |
| LYST | GPR107 | 0.765065 | 3 | 0 | 3 |
| LYST | ATP9A | 0.756975 | 3 | 0 | 3 |
| LYST | TRADD | 0.742728 | 3 | 0 | 3 |
| LYST | AMZ2 | 0.732512 | 3 | 0 | 3 |
| LYST | YLPM1 | 0.731628 | 3 | 0 | 3 |
| LYST | GORASP2 | 0.723001 | 3 | 0 | 3 |
| LYST | SCAPER | 0.719303 | 3 | 0 | 3 |
| LYST | PPIP5K2 | 0.716861 | 3 | 0 | 3 |
| LYST | SNRNP200 | 0.716221 | 3 | 0 | 3 |
| LYST | HELZ | 0.710014 | 3 | 0 | 3 |
| LYST | FYTTD1 | 0.705983 | 4 | 0 | 3 |
| LYST | UBR4 | 0.704676 | 3 | 0 | 3 |
| LYST | WDR26 | 0.699388 | 3 | 0 | 3 |
| LYST | TMEM117 | 0.697202 | 3 | 0 | 3 |
| LYST | DPY30 | 0.696635 | 3 | 0 | 3 |
| LYST | CD44 | 0.695624 | 4 | 0 | 3 |
| LYST | YWHAG | 0.694548 | 3 | 0 | 3 |
| LYST | RLIM | 0.691915 | 4 | 0 | 3 |
For details and further investigation, click here
