| Full name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma | Alias Symbol: PPP1R170 | ||
| Type: protein-coding gene | Cytoband: 7q11.23 | ||
| Entrez ID: 7532 | HGNC ID: HGNC:12852 | Ensembl Gene: ENSG00000170027 | OMIM ID: 605356 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
YWHAG involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle | |
| hsa04114 | Oocyte meiosis | |
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04390 | Hippo signaling pathway |
Expression of YWHAG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | YWHAG | 7532 | 222985_at | 0.6111 | 0.0374 | |
| GSE26886 | YWHAG | 7532 | 222985_at | 0.2819 | 0.0842 | |
| GSE45670 | YWHAG | 7532 | 222985_at | 0.4897 | 0.0019 | |
| GSE53622 | YWHAG | 7532 | 85767 | -0.0291 | 0.7669 | |
| GSE53624 | YWHAG | 7532 | 76458 | 0.6306 | 0.0000 | |
| GSE63941 | YWHAG | 7532 | 222985_at | -0.1590 | 0.6318 | |
| GSE77861 | YWHAG | 7532 | 222985_at | 0.6791 | 0.0004 | |
| GSE97050 | YWHAG | 7532 | A_24_P106681 | 0.0394 | 0.8670 | |
| SRP007169 | YWHAG | 7532 | RNAseq | 0.1582 | 0.7680 | |
| SRP008496 | YWHAG | 7532 | RNAseq | 0.3431 | 0.2531 | |
| SRP064894 | YWHAG | 7532 | RNAseq | 0.1416 | 0.4817 | |
| SRP133303 | YWHAG | 7532 | RNAseq | 0.9776 | 0.0000 | |
| SRP159526 | YWHAG | 7532 | RNAseq | 0.3193 | 0.3231 | |
| SRP193095 | YWHAG | 7532 | RNAseq | 0.6047 | 0.0001 | |
| SRP219564 | YWHAG | 7532 | RNAseq | 0.2992 | 0.3178 | |
| TCGA | YWHAG | 7532 | RNAseq | 0.2298 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by YWHAG expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of YWHAG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | YWHAG | 7532 | 14 | 1 | 15 | |
| GSE20123 | YWHAG | 7532 | 14 | 1 | 15 | |
| GSE43470 | YWHAG | 7532 | 3 | 2 | 38 | |
| GSE46452 | YWHAG | 7532 | 11 | 0 | 48 | |
| GSE47630 | YWHAG | 7532 | 7 | 3 | 30 | |
| GSE54993 | YWHAG | 7532 | 2 | 7 | 61 | |
| GSE54994 | YWHAG | 7532 | 14 | 3 | 36 | |
| GSE60625 | YWHAG | 7532 | 0 | 0 | 11 | |
| GSE74703 | YWHAG | 7532 | 3 | 1 | 32 | |
| GSE74704 | YWHAG | 7532 | 8 | 1 | 11 | |
| TCGA | YWHAG | 7532 | 45 | 5 | 46 |
Total number of gains: 121; Total number of losses: 24; Total Number of normals: 343.
Somatic mutations of YWHAG:
Generating mutation plots.
Highly correlated genes for YWHAG:
Showing top 20/1496 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| YWHAG | TSNAX | 0.854798 | 3 | 0 | 3 |
| YWHAG | U2SURP | 0.805053 | 5 | 0 | 5 |
| YWHAG | COCH | 0.804822 | 5 | 0 | 5 |
| YWHAG | BORA | 0.801027 | 4 | 0 | 4 |
| YWHAG | RTKN | 0.798851 | 5 | 0 | 5 |
| YWHAG | GGNBP2 | 0.7978 | 3 | 0 | 3 |
| YWHAG | SF3B4 | 0.794758 | 4 | 0 | 4 |
| YWHAG | CCNK | 0.790788 | 4 | 0 | 4 |
| YWHAG | SLC39A1 | 0.786032 | 4 | 0 | 4 |
| YWHAG | ZGPAT | 0.777775 | 3 | 0 | 3 |
| YWHAG | SOCS7 | 0.77753 | 4 | 0 | 3 |
| YWHAG | SERPINH1 | 0.776978 | 4 | 0 | 4 |
| YWHAG | CIAO1 | 0.775449 | 4 | 0 | 3 |
| YWHAG | DERL1 | 0.771966 | 3 | 0 | 3 |
| YWHAG | CDCA2 | 0.768218 | 4 | 0 | 4 |
| YWHAG | MAML1 | 0.767277 | 3 | 0 | 3 |
| YWHAG | TUBA1B | 0.763645 | 4 | 0 | 4 |
| YWHAG | TARBP1 | 0.762778 | 3 | 0 | 3 |
| YWHAG | PLAGL2 | 0.759535 | 3 | 0 | 3 |
| YWHAG | PHF5A | 0.75835 | 4 | 0 | 4 |
For details and further investigation, click here
