| Full name: helicase with zinc finger | Alias Symbol: KIAA0054|HUMORF5|DHRC | ||
| Type: protein-coding gene | Cytoband: 17q24.2 | ||
| Entrez ID: 9931 | HGNC ID: HGNC:16878 | Ensembl Gene: ENSG00000198265 | OMIM ID: 606699 |
| Drug and gene relationship at DGIdb | |||
Expression of HELZ:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HELZ | 9931 | 203674_at | 0.5409 | 0.1171 | |
| GSE20347 | HELZ | 9931 | 203674_at | 0.3659 | 0.0050 | |
| GSE23400 | HELZ | 9931 | 203674_at | 0.1633 | 0.0081 | |
| GSE26886 | HELZ | 9931 | 203674_at | 0.8323 | 0.0020 | |
| GSE29001 | HELZ | 9931 | 203674_at | 0.2917 | 0.0406 | |
| GSE38129 | HELZ | 9931 | 203674_at | 0.2007 | 0.0398 | |
| GSE45670 | HELZ | 9931 | 225910_at | -0.1268 | 0.6005 | |
| GSE53622 | HELZ | 9931 | 85324 | -0.0059 | 0.9407 | |
| GSE53624 | HELZ | 9931 | 85324 | 0.1231 | 0.1935 | |
| GSE63941 | HELZ | 9931 | 225910_at | -0.5435 | 0.2617 | |
| GSE77861 | HELZ | 9931 | 203674_at | 0.5915 | 0.0170 | |
| GSE97050 | HELZ | 9931 | A_33_P3257973 | -0.1026 | 0.7108 | |
| SRP007169 | HELZ | 9931 | RNAseq | 1.0753 | 0.0015 | |
| SRP008496 | HELZ | 9931 | RNAseq | 1.0138 | 0.0000 | |
| SRP064894 | HELZ | 9931 | RNAseq | 0.2165 | 0.3252 | |
| SRP133303 | HELZ | 9931 | RNAseq | 0.5362 | 0.0011 | |
| SRP159526 | HELZ | 9931 | RNAseq | 0.1514 | 0.4360 | |
| SRP193095 | HELZ | 9931 | RNAseq | 0.2805 | 0.0001 | |
| SRP219564 | HELZ | 9931 | RNAseq | 0.5236 | 0.0847 | |
| TCGA | HELZ | 9931 | RNAseq | -0.0213 | 0.6516 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by HELZ expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HELZ:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HELZ | 9931 | 3 | 2 | 25 | |
| GSE20123 | HELZ | 9931 | 3 | 2 | 25 | |
| GSE43470 | HELZ | 9931 | 5 | 0 | 38 | |
| GSE46452 | HELZ | 9931 | 31 | 1 | 27 | |
| GSE47630 | HELZ | 9931 | 7 | 1 | 32 | |
| GSE54993 | HELZ | 9931 | 2 | 5 | 63 | |
| GSE54994 | HELZ | 9931 | 9 | 4 | 40 | |
| GSE60625 | HELZ | 9931 | 4 | 2 | 5 | |
| GSE74703 | HELZ | 9931 | 5 | 0 | 31 | |
| GSE74704 | HELZ | 9931 | 3 | 1 | 16 | |
| TCGA | HELZ | 9931 | 28 | 9 | 59 |
Total number of gains: 100; Total number of losses: 27; Total Number of normals: 361.
Somatic mutations of HELZ:
Generating mutation plots.
Highly correlated genes for HELZ:
Showing top 20/1114 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HELZ | ARHGEF2 | 0.816621 | 3 | 0 | 3 |
| HELZ | DNAH14 | 0.805393 | 3 | 0 | 3 |
| HELZ | SLC45A4 | 0.764802 | 3 | 0 | 3 |
| HELZ | TACO1 | 0.76005 | 3 | 0 | 3 |
| HELZ | ULK1 | 0.753629 | 4 | 0 | 3 |
| HELZ | IRF2BP2 | 0.752662 | 3 | 0 | 3 |
| HELZ | SIPA1L2 | 0.750541 | 3 | 0 | 3 |
| HELZ | IGF2R | 0.748435 | 4 | 0 | 3 |
| HELZ | CPLX1 | 0.738396 | 3 | 0 | 3 |
| HELZ | TG | 0.733025 | 3 | 0 | 3 |
| HELZ | CCDC14 | 0.730363 | 3 | 0 | 3 |
| HELZ | C20orf194 | 0.721902 | 3 | 0 | 3 |
| HELZ | SESTD1 | 0.721713 | 4 | 0 | 4 |
| HELZ | TMTC1 | 0.718921 | 3 | 0 | 3 |
| HELZ | RPTOR | 0.717874 | 3 | 0 | 3 |
| HELZ | TTC30B | 0.716969 | 3 | 0 | 3 |
| HELZ | EFCAB7 | 0.714938 | 3 | 0 | 3 |
| HELZ | ZNF518B | 0.714643 | 5 | 0 | 4 |
| HELZ | RDH14 | 0.714333 | 3 | 0 | 3 |
| HELZ | LCLAT1 | 0.714229 | 3 | 0 | 3 |
For details and further investigation, click here
