| Full name: dpy-30 histone methyltransferase complex regulatory subunit | Alias Symbol: Saf19|HDPY-30|Cps25 | ||
| Type: protein-coding gene | Cytoband: 2p22.3 | ||
| Entrez ID: 84661 | HGNC ID: HGNC:24590 | Ensembl Gene: ENSG00000162961 | OMIM ID: 612032 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DPY30:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DPY30 | 84661 | 224129_s_at | 0.2202 | 0.6103 | |
| GSE26886 | DPY30 | 84661 | 224129_s_at | -0.3849 | 0.0342 | |
| GSE45670 | DPY30 | 84661 | 224129_s_at | 0.1884 | 0.1908 | |
| GSE53622 | DPY30 | 84661 | 24497 | 0.3676 | 0.0000 | |
| GSE53624 | DPY30 | 84661 | 24497 | 0.3441 | 0.0000 | |
| GSE63941 | DPY30 | 84661 | 224129_s_at | 1.1216 | 0.0025 | |
| GSE77861 | DPY30 | 84661 | 224129_s_at | 0.1406 | 0.4862 | |
| GSE97050 | DPY30 | 84661 | A_23_P5389 | -0.0532 | 0.9214 | |
| SRP007169 | DPY30 | 84661 | RNAseq | -0.8432 | 0.0181 | |
| SRP008496 | DPY30 | 84661 | RNAseq | -0.5083 | 0.0426 | |
| SRP064894 | DPY30 | 84661 | RNAseq | 0.1201 | 0.5622 | |
| SRP133303 | DPY30 | 84661 | RNAseq | 0.2591 | 0.0750 | |
| SRP159526 | DPY30 | 84661 | RNAseq | 0.2754 | 0.3232 | |
| SRP193095 | DPY30 | 84661 | RNAseq | -0.0204 | 0.8790 | |
| SRP219564 | DPY30 | 84661 | RNAseq | -0.1261 | 0.6861 | |
| TCGA | DPY30 | 84661 | RNAseq | 0.2478 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by DPY30 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DPY30:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DPY30 | 84661 | 10 | 1 | 19 | |
| GSE20123 | DPY30 | 84661 | 9 | 1 | 20 | |
| GSE43470 | DPY30 | 84661 | 2 | 1 | 40 | |
| GSE46452 | DPY30 | 84661 | 2 | 4 | 53 | |
| GSE47630 | DPY30 | 84661 | 8 | 0 | 32 | |
| GSE54993 | DPY30 | 84661 | 0 | 5 | 65 | |
| GSE54994 | DPY30 | 84661 | 10 | 1 | 42 | |
| GSE60625 | DPY30 | 84661 | 0 | 3 | 8 | |
| GSE74703 | DPY30 | 84661 | 2 | 0 | 34 | |
| GSE74704 | DPY30 | 84661 | 9 | 1 | 10 | |
| TCGA | DPY30 | 84661 | 36 | 2 | 58 |
Total number of gains: 88; Total number of losses: 19; Total Number of normals: 381.
Somatic mutations of DPY30:
Generating mutation plots.
Highly correlated genes for DPY30:
Showing top 20/619 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DPY30 | ELOVL7 | 0.75876 | 3 | 0 | 3 |
| DPY30 | PPP2CA | 0.730862 | 3 | 0 | 3 |
| DPY30 | IMPA2 | 0.7289 | 3 | 0 | 3 |
| DPY30 | TMEM54 | 0.720626 | 3 | 0 | 3 |
| DPY30 | VPS25 | 0.704379 | 3 | 0 | 3 |
| DPY30 | TRMT2B | 0.703433 | 3 | 0 | 3 |
| DPY30 | STON2 | 0.703269 | 3 | 0 | 3 |
| DPY30 | RALBP1 | 0.702371 | 3 | 0 | 3 |
| DPY30 | BTF3 | 0.696832 | 3 | 0 | 3 |
| DPY30 | LYST | 0.696635 | 3 | 0 | 3 |
| DPY30 | MDH1 | 0.695066 | 7 | 0 | 5 |
| DPY30 | SDHC | 0.694051 | 3 | 0 | 3 |
| DPY30 | ZNF207 | 0.68759 | 3 | 0 | 3 |
| DPY30 | COX4I1 | 0.686067 | 3 | 0 | 3 |
| DPY30 | METAP2 | 0.685782 | 5 | 0 | 4 |
| DPY30 | GEMIN6 | 0.682546 | 8 | 0 | 8 |
| DPY30 | BORA | 0.675196 | 4 | 0 | 4 |
| DPY30 | PUM2 | 0.673617 | 4 | 0 | 4 |
| DPY30 | SNX17 | 0.668201 | 6 | 0 | 5 |
| DPY30 | ACO2 | 0.665702 | 3 | 0 | 3 |
For details and further investigation, click here
