| Full name: ubiquitin protein ligase E3 component n-recognin 4 | Alias Symbol: KIAA1307|KIAA0462|RBAF600 | ||
| Type: protein-coding gene | Cytoband: 1p36.13 | ||
| Entrez ID: 23352 | HGNC ID: HGNC:30313 | Ensembl Gene: ENSG00000127481 | OMIM ID: 609890 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UBR4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UBR4 | 23352 | 211950_at | 0.2227 | 0.3206 | |
| GSE20347 | UBR4 | 23352 | 211950_at | -0.3525 | 0.0011 | |
| GSE23400 | UBR4 | 23352 | 211950_at | 0.0112 | 0.8772 | |
| GSE26886 | UBR4 | 23352 | 211950_at | -0.4860 | 0.0231 | |
| GSE29001 | UBR4 | 23352 | 211950_at | -0.2889 | 0.4416 | |
| GSE38129 | UBR4 | 23352 | 211950_at | -0.2184 | 0.0116 | |
| GSE45670 | UBR4 | 23352 | 211950_at | 0.2363 | 0.3288 | |
| GSE53622 | UBR4 | 23352 | 51168 | 0.4326 | 0.0001 | |
| GSE53624 | UBR4 | 23352 | 51168 | 0.1246 | 0.0947 | |
| GSE63941 | UBR4 | 23352 | 211950_at | -0.5908 | 0.0952 | |
| GSE77861 | UBR4 | 23352 | 211950_at | -0.0204 | 0.9366 | |
| GSE97050 | UBR4 | 23352 | A_33_P3767773 | 0.0750 | 0.6998 | |
| SRP007169 | UBR4 | 23352 | RNAseq | 0.4196 | 0.3201 | |
| SRP008496 | UBR4 | 23352 | RNAseq | 0.1904 | 0.4225 | |
| SRP064894 | UBR4 | 23352 | RNAseq | 0.1886 | 0.3385 | |
| SRP133303 | UBR4 | 23352 | RNAseq | 0.1302 | 0.3831 | |
| SRP159526 | UBR4 | 23352 | RNAseq | 0.0381 | 0.9042 | |
| SRP193095 | UBR4 | 23352 | RNAseq | 0.3473 | 0.0011 | |
| SRP219564 | UBR4 | 23352 | RNAseq | -0.2339 | 0.4104 | |
| TCGA | UBR4 | 23352 | RNAseq | -0.1103 | 0.0038 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by UBR4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UBR4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UBR4 | 23352 | 0 | 5 | 25 | |
| GSE20123 | UBR4 | 23352 | 0 | 4 | 26 | |
| GSE43470 | UBR4 | 23352 | 0 | 8 | 35 | |
| GSE46452 | UBR4 | 23352 | 5 | 1 | 53 | |
| GSE47630 | UBR4 | 23352 | 8 | 3 | 29 | |
| GSE54993 | UBR4 | 23352 | 3 | 1 | 66 | |
| GSE54994 | UBR4 | 23352 | 11 | 4 | 38 | |
| GSE60625 | UBR4 | 23352 | 0 | 0 | 11 | |
| GSE74703 | UBR4 | 23352 | 0 | 5 | 31 | |
| GSE74704 | UBR4 | 23352 | 0 | 0 | 20 | |
| TCGA | UBR4 | 23352 | 10 | 22 | 64 |
Total number of gains: 37; Total number of losses: 53; Total Number of normals: 398.
Somatic mutations of UBR4:
Generating mutation plots.
Highly correlated genes for UBR4:
Showing top 20/261 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UBR4 | PHLDB1 | 0.751811 | 3 | 0 | 3 |
| UBR4 | GRWD1 | 0.750241 | 3 | 0 | 3 |
| UBR4 | TSPAN17 | 0.743645 | 3 | 0 | 3 |
| UBR4 | KCNJ5 | 0.741809 | 3 | 0 | 3 |
| UBR4 | FASN | 0.738362 | 3 | 0 | 3 |
| UBR4 | PRDM15 | 0.727774 | 3 | 0 | 3 |
| UBR4 | EHMT2 | 0.719327 | 3 | 0 | 3 |
| UBR4 | MEAF6 | 0.715649 | 3 | 0 | 3 |
| UBR4 | SUPT4H1 | 0.713736 | 3 | 0 | 3 |
| UBR4 | FRMD8 | 0.711934 | 3 | 0 | 3 |
| UBR4 | HYOU1 | 0.706437 | 5 | 0 | 5 |
| UBR4 | LYST | 0.704676 | 3 | 0 | 3 |
| UBR4 | GMPPA | 0.700281 | 3 | 0 | 3 |
| UBR4 | HPS4 | 0.695741 | 4 | 0 | 4 |
| UBR4 | TPD52L2 | 0.692185 | 3 | 0 | 3 |
| UBR4 | FAM193B | 0.68654 | 4 | 0 | 4 |
| UBR4 | CXXC1 | 0.686057 | 4 | 0 | 3 |
| UBR4 | ARHGEF19 | 0.682479 | 3 | 0 | 3 |
| UBR4 | EPG5 | 0.681309 | 3 | 0 | 3 |
| UBR4 | SMOX | 0.681173 | 3 | 0 | 3 |
For details and further investigation, click here
