| Full name: CD44 molecule (Indian blood group) | Alias Symbol: IN|MC56|Pgp1|CD44R|HCELL|CSPG8 | ||
| Type: protein-coding gene | Cytoband: 11p13 | ||
| Entrez ID: 960 | HGNC ID: HGNC:1681 | Ensembl Gene: ENSG00000026508 | OMIM ID: 107269 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
CD44 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05205 | Proteoglycans in cancer |
Expression of CD44:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CD44 | 960 | 212063_at | -0.3660 | 0.6144 | |
| GSE20347 | CD44 | 960 | 212063_at | -0.2842 | 0.0896 | |
| GSE23400 | CD44 | 960 | 212063_at | 0.2923 | 0.0025 | |
| GSE26886 | CD44 | 960 | 212063_at | 0.9021 | 0.0003 | |
| GSE29001 | CD44 | 960 | 212063_at | 0.1803 | 0.5685 | |
| GSE38129 | CD44 | 960 | 212063_at | -0.1842 | 0.2600 | |
| GSE45670 | CD44 | 960 | 212063_at | 0.3523 | 0.0390 | |
| GSE53622 | CD44 | 960 | 15087 | -0.1148 | 0.1871 | |
| GSE53624 | CD44 | 960 | 15087 | 0.1863 | 0.0245 | |
| GSE63941 | CD44 | 960 | 212063_at | -2.2957 | 0.0105 | |
| GSE77861 | CD44 | 960 | 212063_at | 0.4374 | 0.0690 | |
| GSE97050 | CD44 | 960 | A_33_P3294509 | 0.2578 | 0.3008 | |
| SRP007169 | CD44 | 960 | RNAseq | 0.5790 | 0.1379 | |
| SRP008496 | CD44 | 960 | RNAseq | 0.4822 | 0.0313 | |
| SRP064894 | CD44 | 960 | RNAseq | 1.0901 | 0.0004 | |
| SRP133303 | CD44 | 960 | RNAseq | 0.9251 | 0.0000 | |
| SRP159526 | CD44 | 960 | RNAseq | 0.1003 | 0.8053 | |
| SRP193095 | CD44 | 960 | RNAseq | 0.5009 | 0.0163 | |
| SRP219564 | CD44 | 960 | RNAseq | 0.4336 | 0.2450 | |
| TCGA | CD44 | 960 | RNAseq | 0.4123 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by CD44 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CD44:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CD44 | 960 | 2 | 7 | 21 | |
| GSE20123 | CD44 | 960 | 2 | 5 | 23 | |
| GSE43470 | CD44 | 960 | 3 | 4 | 36 | |
| GSE46452 | CD44 | 960 | 7 | 5 | 47 | |
| GSE47630 | CD44 | 960 | 3 | 10 | 27 | |
| GSE54993 | CD44 | 960 | 3 | 2 | 65 | |
| GSE54994 | CD44 | 960 | 3 | 10 | 40 | |
| GSE60625 | CD44 | 960 | 0 | 0 | 11 | |
| GSE74703 | CD44 | 960 | 2 | 2 | 32 | |
| GSE74704 | CD44 | 960 | 0 | 3 | 17 | |
| TCGA | CD44 | 960 | 20 | 22 | 54 |
Total number of gains: 45; Total number of losses: 70; Total Number of normals: 373.
Somatic mutations of CD44:
Generating mutation plots.
Highly correlated genes for CD44:
Showing top 20/554 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CD44 | KLHL13 | 0.846615 | 3 | 0 | 3 |
| CD44 | VBP1 | 0.836888 | 3 | 0 | 3 |
| CD44 | CPSF3 | 0.824387 | 3 | 0 | 3 |
| CD44 | PPHLN1 | 0.799545 | 3 | 0 | 3 |
| CD44 | ALKBH6 | 0.795394 | 3 | 0 | 3 |
| CD44 | AKR1C2 | 0.777722 | 3 | 0 | 3 |
| CD44 | SNRNP27 | 0.76977 | 3 | 0 | 3 |
| CD44 | CNRIP1 | 0.766946 | 3 | 0 | 3 |
| CD44 | C1orf216 | 0.766163 | 4 | 0 | 4 |
| CD44 | SMAD5 | 0.763876 | 3 | 0 | 3 |
| CD44 | CHST12 | 0.763609 | 3 | 0 | 3 |
| CD44 | VRK2 | 0.763497 | 3 | 0 | 3 |
| CD44 | CDC42SE2 | 0.762137 | 4 | 0 | 4 |
| CD44 | LCLAT1 | 0.757691 | 3 | 0 | 3 |
| CD44 | SAAL1 | 0.756589 | 3 | 0 | 3 |
| CD44 | RILPL2 | 0.753733 | 3 | 0 | 3 |
| CD44 | A1BG | 0.750891 | 3 | 0 | 3 |
| CD44 | SHANK3 | 0.748066 | 3 | 0 | 3 |
| CD44 | UHRF1BP1L | 0.746557 | 3 | 0 | 3 |
| CD44 | USP12 | 0.745692 | 3 | 0 | 3 |
For details and further investigation, click here
