| Full name: mitogen-activated protein kinase 8 interacting protein 2 | Alias Symbol: IB2|JIP2 | ||
| Type: protein-coding gene | Cytoband: 22q13.33 | ||
| Entrez ID: 23542 | HGNC ID: HGNC:6883 | Ensembl Gene: ENSG00000008735 | OMIM ID: 607755 |
| Drug and gene relationship at DGIdb | |||
MAPK8IP2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway |
Expression of MAPK8IP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAPK8IP2 | 23542 | 208603_s_at | -0.0216 | 0.9527 | |
| GSE20347 | MAPK8IP2 | 23542 | 208603_s_at | -0.0438 | 0.5783 | |
| GSE23400 | MAPK8IP2 | 23542 | 208603_s_at | -0.0520 | 0.1922 | |
| GSE26886 | MAPK8IP2 | 23542 | 205050_s_at | 0.5825 | 0.0000 | |
| GSE29001 | MAPK8IP2 | 23542 | 205050_s_at | -0.0985 | 0.6141 | |
| GSE38129 | MAPK8IP2 | 23542 | 208603_s_at | -0.1412 | 0.0232 | |
| GSE45670 | MAPK8IP2 | 23542 | 208603_s_at | 0.0968 | 0.2660 | |
| GSE53622 | MAPK8IP2 | 23542 | 19258 | 0.4396 | 0.0092 | |
| GSE53624 | MAPK8IP2 | 23542 | 19258 | 0.7207 | 0.0000 | |
| GSE63941 | MAPK8IP2 | 23542 | 208603_s_at | 0.1479 | 0.4704 | |
| GSE77861 | MAPK8IP2 | 23542 | 205050_s_at | 0.0930 | 0.7008 | |
| GSE97050 | MAPK8IP2 | 23542 | A_23_P502078 | 0.1591 | 0.5493 | |
| SRP007169 | MAPK8IP2 | 23542 | RNAseq | 0.9506 | 0.3282 | |
| SRP064894 | MAPK8IP2 | 23542 | RNAseq | 2.4338 | 0.0000 | |
| SRP133303 | MAPK8IP2 | 23542 | RNAseq | 1.1528 | 0.0078 | |
| SRP159526 | MAPK8IP2 | 23542 | RNAseq | 2.0024 | 0.0042 | |
| SRP193095 | MAPK8IP2 | 23542 | RNAseq | 1.0691 | 0.0000 | |
| SRP219564 | MAPK8IP2 | 23542 | RNAseq | 0.8378 | 0.1199 | |
| TCGA | MAPK8IP2 | 23542 | RNAseq | 0.5019 | 0.0221 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by MAPK8IP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAPK8IP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAPK8IP2 | 23542 | 3 | 8 | 19 | |
| GSE20123 | MAPK8IP2 | 23542 | 3 | 8 | 19 | |
| GSE43470 | MAPK8IP2 | 23542 | 2 | 8 | 33 | |
| GSE46452 | MAPK8IP2 | 23542 | 31 | 2 | 26 | |
| GSE47630 | MAPK8IP2 | 23542 | 9 | 4 | 27 | |
| GSE54993 | MAPK8IP2 | 23542 | 4 | 6 | 60 | |
| GSE54994 | MAPK8IP2 | 23542 | 11 | 8 | 34 | |
| GSE60625 | MAPK8IP2 | 23542 | 5 | 0 | 6 | |
| GSE74703 | MAPK8IP2 | 23542 | 2 | 6 | 28 | |
| GSE74704 | MAPK8IP2 | 23542 | 1 | 4 | 15 | |
| TCGA | MAPK8IP2 | 23542 | 26 | 16 | 54 |
Total number of gains: 97; Total number of losses: 70; Total Number of normals: 321.
Somatic mutations of MAPK8IP2:
Generating mutation plots.
Highly correlated genes for MAPK8IP2:
Showing top 20/768 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAPK8IP2 | TMEM102 | 0.853162 | 3 | 0 | 3 |
| MAPK8IP2 | RASL10B | 0.828054 | 3 | 0 | 3 |
| MAPK8IP2 | CPAMD8 | 0.814937 | 3 | 0 | 3 |
| MAPK8IP2 | C19orf44 | 0.805843 | 3 | 0 | 3 |
| MAPK8IP2 | RIMS4 | 0.793543 | 3 | 0 | 3 |
| MAPK8IP2 | ZNF444 | 0.782349 | 4 | 0 | 4 |
| MAPK8IP2 | ESPNL | 0.780984 | 3 | 0 | 3 |
| MAPK8IP2 | SHISA4 | 0.780631 | 3 | 0 | 3 |
| MAPK8IP2 | CDR2L | 0.77351 | 3 | 0 | 3 |
| MAPK8IP2 | MAPK15 | 0.772166 | 4 | 0 | 4 |
| MAPK8IP2 | GTF2IRD2 | 0.759185 | 3 | 0 | 3 |
| MAPK8IP2 | TFE3 | 0.756796 | 4 | 0 | 4 |
| MAPK8IP2 | PPP1R12C | 0.751796 | 3 | 0 | 3 |
| MAPK8IP2 | PNMA6A | 0.749109 | 3 | 0 | 3 |
| MAPK8IP2 | MAMLD1 | 0.746504 | 3 | 0 | 3 |
| MAPK8IP2 | ZNF81 | 0.74393 | 3 | 0 | 3 |
| MAPK8IP2 | PNMA3 | 0.74271 | 5 | 0 | 5 |
| MAPK8IP2 | FBLN7 | 0.739435 | 3 | 0 | 3 |
| MAPK8IP2 | ARHGAP30 | 0.739104 | 3 | 0 | 3 |
| MAPK8IP2 | RLN3 | 0.736623 | 3 | 0 | 3 |
For details and further investigation, click here
