| Full name: mitogen-activated protein kinase 15 | Alias Symbol: ERK8|ERK7 | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 225689 | HGNC ID: HGNC:24667 | Ensembl Gene: ENSG00000181085 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of MAPK15:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAPK15 | 225689 | 241357_at | 0.1707 | 0.3819 | |
| GSE26886 | MAPK15 | 225689 | 241357_at | 0.3929 | 0.0023 | |
| GSE45670 | MAPK15 | 225689 | 241357_at | -0.0221 | 0.8467 | |
| GSE53622 | MAPK15 | 225689 | 128973 | 0.5257 | 0.0000 | |
| GSE53624 | MAPK15 | 225689 | 7765 | 0.1292 | 0.1449 | |
| GSE63941 | MAPK15 | 225689 | 241357_at | 0.3612 | 0.0918 | |
| GSE77861 | MAPK15 | 225689 | 241357_at | -0.0112 | 0.9486 | |
| GSE97050 | MAPK15 | 225689 | A_24_P89835 | 0.4116 | 0.1403 | |
| SRP064894 | MAPK15 | 225689 | RNAseq | 0.6357 | 0.1057 | |
| SRP133303 | MAPK15 | 225689 | RNAseq | -0.0051 | 0.9898 | |
| SRP159526 | MAPK15 | 225689 | RNAseq | 2.2358 | 0.0001 | |
| SRP219564 | MAPK15 | 225689 | RNAseq | 0.6073 | 0.3908 | |
| TCGA | MAPK15 | 225689 | RNAseq | 1.7911 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by MAPK15 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAPK15:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAPK15 | 225689 | 17 | 1 | 12 | |
| GSE20123 | MAPK15 | 225689 | 17 | 1 | 12 | |
| GSE43470 | MAPK15 | 225689 | 16 | 2 | 25 | |
| GSE46452 | MAPK15 | 225689 | 27 | 0 | 32 | |
| GSE47630 | MAPK15 | 225689 | 23 | 1 | 16 | |
| GSE54993 | MAPK15 | 225689 | 0 | 25 | 45 | |
| GSE54994 | MAPK15 | 225689 | 39 | 1 | 13 | |
| GSE60625 | MAPK15 | 225689 | 3 | 4 | 4 | |
| GSE74703 | MAPK15 | 225689 | 14 | 1 | 21 | |
| GSE74704 | MAPK15 | 225689 | 10 | 0 | 10 | |
| TCGA | MAPK15 | 225689 | 64 | 2 | 30 |
Total number of gains: 230; Total number of losses: 38; Total Number of normals: 220.
Somatic mutations of MAPK15:
Generating mutation plots.
Highly correlated genes for MAPK15:
Showing top 20/491 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAPK15 | FOXB1 | 0.783441 | 3 | 0 | 3 |
| MAPK15 | MAPK8IP2 | 0.772166 | 4 | 0 | 4 |
| MAPK15 | TSPAN11 | 0.769048 | 3 | 0 | 3 |
| MAPK15 | GPR150 | 0.766463 | 3 | 0 | 3 |
| MAPK15 | RIN1 | 0.763863 | 3 | 0 | 3 |
| MAPK15 | PROC | 0.755889 | 3 | 0 | 3 |
| MAPK15 | GNB3 | 0.749516 | 4 | 0 | 4 |
| MAPK15 | IPO13 | 0.749347 | 3 | 0 | 3 |
| MAPK15 | REG3A | 0.740579 | 3 | 0 | 3 |
| MAPK15 | PTPRH | 0.730301 | 3 | 0 | 3 |
| MAPK15 | BMP10 | 0.730127 | 3 | 0 | 3 |
| MAPK15 | TSPAN10 | 0.729768 | 3 | 0 | 3 |
| MAPK15 | LRSAM1 | 0.729645 | 3 | 0 | 3 |
| MAPK15 | CLCNKB | 0.728601 | 3 | 0 | 3 |
| MAPK15 | SYT2 | 0.724162 | 3 | 0 | 3 |
| MAPK15 | SYCE1L | 0.719351 | 3 | 0 | 3 |
| MAPK15 | PSMB11 | 0.714632 | 3 | 0 | 3 |
| MAPK15 | EPX | 0.713139 | 3 | 0 | 3 |
| MAPK15 | GDPD5 | 0.710656 | 3 | 0 | 3 |
| MAPK15 | GRAP | 0.708923 | 3 | 0 | 3 |
For details and further investigation, click here
