| Full name: methionine adenosyltransferase 1A | Alias Symbol: MAT|SAMS|MATA1|SAMS1 | ||
| Type: protein-coding gene | Cytoband: 10q22.3 | ||
| Entrez ID: 4143 | HGNC ID: HGNC:6903 | Ensembl Gene: ENSG00000151224 | OMIM ID: 610550 |
| Drug and gene relationship at DGIdb | |||
Expression of MAT1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAT1A | 4143 | 205813_s_at | 0.0715 | 0.7683 | |
| GSE20347 | MAT1A | 4143 | 205813_s_at | 0.1400 | 0.1732 | |
| GSE23400 | MAT1A | 4143 | 205813_s_at | -0.0845 | 0.0267 | |
| GSE26886 | MAT1A | 4143 | 205813_s_at | 0.0611 | 0.6056 | |
| GSE29001 | MAT1A | 4143 | 205813_s_at | -0.3126 | 0.0495 | |
| GSE38129 | MAT1A | 4143 | 205813_s_at | 0.0475 | 0.7037 | |
| GSE45670 | MAT1A | 4143 | 205813_s_at | 0.0149 | 0.9150 | |
| GSE53622 | MAT1A | 4143 | 56458 | 0.1248 | 0.0749 | |
| GSE53624 | MAT1A | 4143 | 56458 | 0.3166 | 0.0001 | |
| GSE63941 | MAT1A | 4143 | 205813_s_at | 0.0360 | 0.8089 | |
| GSE77861 | MAT1A | 4143 | 205813_s_at | -0.1193 | 0.3161 | |
| GSE97050 | MAT1A | 4143 | A_23_P23996 | -0.0333 | 0.8973 | |
| SRP219564 | MAT1A | 4143 | RNAseq | 1.0524 | 0.0879 | |
| TCGA | MAT1A | 4143 | RNAseq | 2.0630 | 0.0001 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MAT1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAT1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAT1A | 4143 | 2 | 4 | 24 | |
| GSE20123 | MAT1A | 4143 | 2 | 3 | 25 | |
| GSE43470 | MAT1A | 4143 | 1 | 7 | 35 | |
| GSE46452 | MAT1A | 4143 | 0 | 11 | 48 | |
| GSE47630 | MAT1A | 4143 | 2 | 14 | 24 | |
| GSE54993 | MAT1A | 4143 | 7 | 0 | 63 | |
| GSE54994 | MAT1A | 4143 | 1 | 12 | 40 | |
| GSE60625 | MAT1A | 4143 | 0 | 0 | 11 | |
| GSE74703 | MAT1A | 4143 | 1 | 4 | 31 | |
| GSE74704 | MAT1A | 4143 | 1 | 1 | 18 | |
| TCGA | MAT1A | 4143 | 10 | 24 | 62 |
Total number of gains: 27; Total number of losses: 80; Total Number of normals: 381.
Somatic mutations of MAT1A:
Generating mutation plots.
Highly correlated genes for MAT1A:
Showing top 20/962 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAT1A | ABCA4 | 0.803144 | 3 | 0 | 3 |
| MAT1A | TMUB1 | 0.76793 | 3 | 0 | 3 |
| MAT1A | ZNF777 | 0.764489 | 3 | 0 | 3 |
| MAT1A | RAB3IL1 | 0.758933 | 5 | 0 | 5 |
| MAT1A | PGC | 0.747429 | 4 | 0 | 3 |
| MAT1A | RNF123 | 0.745099 | 4 | 0 | 3 |
| MAT1A | AZU1 | 0.743881 | 4 | 0 | 3 |
| MAT1A | CC2D1B | 0.735084 | 3 | 0 | 3 |
| MAT1A | PPP1R13B | 0.734978 | 4 | 0 | 4 |
| MAT1A | C7orf61 | 0.730148 | 3 | 0 | 3 |
| MAT1A | DAB1 | 0.727324 | 6 | 0 | 6 |
| MAT1A | FRMPD4 | 0.723893 | 3 | 0 | 3 |
| MAT1A | SLC5A4 | 0.722075 | 5 | 0 | 5 |
| MAT1A | ATG16L1 | 0.72114 | 3 | 0 | 3 |
| MAT1A | GMEB1 | 0.718986 | 3 | 0 | 3 |
| MAT1A | FAM71F1 | 0.709715 | 3 | 0 | 3 |
| MAT1A | ZNF835 | 0.708701 | 4 | 0 | 4 |
| MAT1A | ZNF236 | 0.706023 | 5 | 0 | 4 |
| MAT1A | RCOR2 | 0.700246 | 4 | 0 | 3 |
| MAT1A | USP51 | 0.699415 | 3 | 0 | 3 |
For details and further investigation, click here
