| Full name: ATP binding cassette subfamily A member 4 | Alias Symbol: FFM|ARMD2|CORD3 | ||
| Type: protein-coding gene | Cytoband: 1p22.1 | ||
| Entrez ID: 24 | HGNC ID: HGNC:34 | Ensembl Gene: ENSG00000198691 | OMIM ID: 601691 |
| Drug and gene relationship at DGIdb | |||
Expression of ABCA4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ABCA4 | 24 | 210082_at | 0.3065 | 0.6528 | |
| GSE20347 | ABCA4 | 24 | 210082_at | 0.0585 | 0.6129 | |
| GSE23400 | ABCA4 | 24 | 210082_at | -0.0483 | 0.5769 | |
| GSE26886 | ABCA4 | 24 | 210082_at | -0.2766 | 0.0515 | |
| GSE29001 | ABCA4 | 24 | 210082_at | -0.1940 | 0.1687 | |
| GSE38129 | ABCA4 | 24 | 210082_at | 0.0696 | 0.7098 | |
| GSE45670 | ABCA4 | 24 | 210082_at | 0.3888 | 0.1613 | |
| GSE53622 | ABCA4 | 24 | 15481 | 0.7067 | 0.0016 | |
| GSE53624 | ABCA4 | 24 | 15481 | 0.9589 | 0.0000 | |
| GSE63941 | ABCA4 | 24 | 210082_at | 0.5118 | 0.0496 | |
| GSE77861 | ABCA4 | 24 | 210082_at | -0.1982 | 0.2049 | |
| GSE97050 | ABCA4 | 24 | A_23_P160940 | 0.3794 | 0.2151 | |
| TCGA | ABCA4 | 24 | RNAseq | 1.3582 | 0.0186 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ABCA4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ABCA4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ABCA4 | 24 | 0 | 8 | 22 | |
| GSE20123 | ABCA4 | 24 | 0 | 8 | 22 | |
| GSE43470 | ABCA4 | 24 | 2 | 6 | 35 | |
| GSE46452 | ABCA4 | 24 | 1 | 1 | 57 | |
| GSE47630 | ABCA4 | 24 | 8 | 5 | 27 | |
| GSE54993 | ABCA4 | 24 | 0 | 1 | 69 | |
| GSE54994 | ABCA4 | 24 | 6 | 3 | 44 | |
| GSE60625 | ABCA4 | 24 | 0 | 0 | 11 | |
| GSE74703 | ABCA4 | 24 | 1 | 5 | 30 | |
| GSE74704 | ABCA4 | 24 | 0 | 5 | 15 | |
| TCGA | ABCA4 | 24 | 6 | 24 | 66 |
Total number of gains: 24; Total number of losses: 66; Total Number of normals: 398.
Somatic mutations of ABCA4:
Generating mutation plots.
Highly correlated genes for ABCA4:
Showing top 20/629 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ABCA4 | ALPL | 0.84736 | 3 | 0 | 3 |
| ABCA4 | MAT1A | 0.803144 | 3 | 0 | 3 |
| ABCA4 | ZNF821 | 0.790895 | 3 | 0 | 3 |
| ABCA4 | TRAPPC9 | 0.779352 | 3 | 0 | 3 |
| ABCA4 | SRD5A2 | 0.772769 | 3 | 0 | 3 |
| ABCA4 | NCR3 | 0.763507 | 4 | 0 | 4 |
| ABCA4 | GPSM3 | 0.763394 | 5 | 0 | 5 |
| ABCA4 | PTPRCAP | 0.762302 | 3 | 0 | 3 |
| ABCA4 | S1PR4 | 0.761196 | 4 | 0 | 4 |
| ABCA4 | SRCIN1 | 0.757791 | 3 | 0 | 3 |
| ABCA4 | FMNL1 | 0.753537 | 3 | 0 | 3 |
| ABCA4 | HPS1 | 0.748738 | 3 | 0 | 3 |
| ABCA4 | GPR182 | 0.745888 | 5 | 0 | 5 |
| ABCA4 | ACR | 0.73745 | 5 | 0 | 4 |
| ABCA4 | NFIA-AS2 | 0.734233 | 4 | 0 | 4 |
| ABCA4 | GFRA4 | 0.733116 | 5 | 0 | 5 |
| ABCA4 | HTR3A | 0.730272 | 5 | 0 | 5 |
| ABCA4 | FCRL2 | 0.726794 | 3 | 0 | 3 |
| ABCA4 | CNGB3 | 0.724167 | 5 | 0 | 5 |
| ABCA4 | KIR3DL3 | 0.716987 | 5 | 0 | 4 |
For details and further investigation, click here
