| Full name: melanocortin 2 receptor | Alias Symbol: ACTHR | ||
| Type: protein-coding gene | Cytoband: 18p11.2 | ||
| Entrez ID: 4158 | HGNC ID: HGNC:6930 | Ensembl Gene: ENSG00000185231 | OMIM ID: 607397 |
| Drug and gene relationship at DGIdb | |||
MC2R involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway | |
| hsa04925 | Aldosterone synthesis and secretion |
Expression of MC2R:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MC2R | 4158 | 208568_at | -0.0298 | 0.9147 | |
| GSE20347 | MC2R | 4158 | 208568_at | 0.0743 | 0.4330 | |
| GSE23400 | MC2R | 4158 | 208568_at | -0.0522 | 0.2419 | |
| GSE26886 | MC2R | 4158 | 208568_at | 0.0188 | 0.8872 | |
| GSE29001 | MC2R | 4158 | 208568_at | -0.2009 | 0.2388 | |
| GSE38129 | MC2R | 4158 | 208568_at | -0.0156 | 0.8879 | |
| GSE45670 | MC2R | 4158 | 208568_at | 0.0076 | 0.9450 | |
| GSE53622 | MC2R | 4158 | 66553 | 0.1979 | 0.1539 | |
| GSE53624 | MC2R | 4158 | 66553 | -0.1123 | 0.2424 | |
| GSE63941 | MC2R | 4158 | 208568_at | 0.2367 | 0.0697 | |
| GSE77861 | MC2R | 4158 | 208568_at | -0.0125 | 0.9486 | |
| SRP133303 | MC2R | 4158 | RNAseq | 0.1604 | 0.4367 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MC2R expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MC2R:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MC2R | 4158 | 5 | 3 | 22 | |
| GSE20123 | MC2R | 4158 | 5 | 3 | 22 | |
| GSE43470 | MC2R | 4158 | 0 | 6 | 37 | |
| GSE46452 | MC2R | 4158 | 3 | 21 | 35 | |
| GSE47630 | MC2R | 4158 | 7 | 17 | 16 | |
| GSE54993 | MC2R | 4158 | 6 | 2 | 62 | |
| GSE54994 | MC2R | 4158 | 9 | 8 | 36 | |
| GSE60625 | MC2R | 4158 | 0 | 4 | 7 | |
| GSE74703 | MC2R | 4158 | 0 | 4 | 32 | |
| GSE74704 | MC2R | 4158 | 3 | 2 | 15 | |
| TCGA | MC2R | 4158 | 27 | 23 | 46 |
Total number of gains: 65; Total number of losses: 93; Total Number of normals: 330.
Somatic mutations of MC2R:
Generating mutation plots.
Highly correlated genes for MC2R:
Showing top 20/1003 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MC2R | EDA2R | 0.745364 | 5 | 0 | 5 |
| MC2R | NEUROD2 | 0.743245 | 4 | 0 | 4 |
| MC2R | OR10H3 | 0.729171 | 7 | 0 | 7 |
| MC2R | DNAJA4 | 0.728947 | 4 | 0 | 4 |
| MC2R | NXPE4 | 0.727645 | 6 | 0 | 5 |
| MC2R | IL1RAPL2 | 0.724781 | 6 | 0 | 6 |
| MC2R | KSR1 | 0.723292 | 3 | 0 | 3 |
| MC2R | LUZP4 | 0.721055 | 6 | 0 | 6 |
| MC2R | ARHGEF38 | 0.715481 | 6 | 0 | 6 |
| MC2R | PRORY | 0.707745 | 5 | 0 | 4 |
| MC2R | NTNG1 | 0.706533 | 4 | 0 | 4 |
| MC2R | NHLH1 | 0.706157 | 5 | 0 | 4 |
| MC2R | CHRNA6 | 0.703848 | 4 | 0 | 4 |
| MC2R | C11orf16 | 0.697986 | 6 | 0 | 5 |
| MC2R | FSCN3 | 0.69051 | 6 | 0 | 6 |
| MC2R | CYP3A4 | 0.686303 | 4 | 0 | 3 |
| MC2R | SIGLEC8 | 0.686151 | 3 | 0 | 3 |
| MC2R | GP2 | 0.685379 | 5 | 0 | 5 |
| MC2R | CHST4 | 0.683426 | 4 | 0 | 3 |
| MC2R | RRH | 0.681638 | 4 | 0 | 4 |
For details and further investigation, click here
