| Full name: sialic acid binding Ig like lectin 8 | Alias Symbol: SIGLEC-8|SAF2|SIGLEC8L|MGC59785 | ||
| Type: protein-coding gene | Cytoband: 19q13.33-q13.41 | ||
| Entrez ID: 27181 | HGNC ID: HGNC:10877 | Ensembl Gene: ENSG00000105366 | OMIM ID: 605639 |
| Drug and gene relationship at DGIdb | |||
Expression of SIGLEC8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIGLEC8 | 27181 | 216327_s_at | -0.1948 | 0.4167 | |
| GSE20347 | SIGLEC8 | 27181 | 216327_s_at | -0.1234 | 0.1086 | |
| GSE23400 | SIGLEC8 | 27181 | 208253_at | -0.0183 | 0.4369 | |
| GSE26886 | SIGLEC8 | 27181 | 216327_s_at | 0.3555 | 0.0228 | |
| GSE29001 | SIGLEC8 | 27181 | 208253_at | -0.0762 | 0.5983 | |
| GSE38129 | SIGLEC8 | 27181 | 216327_s_at | -0.1253 | 0.2758 | |
| GSE45670 | SIGLEC8 | 27181 | 216327_s_at | -0.0189 | 0.8755 | |
| GSE53622 | SIGLEC8 | 27181 | 88209 | -0.0528 | 0.7980 | |
| GSE53624 | SIGLEC8 | 27181 | 88209 | -0.1709 | 0.3656 | |
| GSE63941 | SIGLEC8 | 27181 | 216327_s_at | 0.1619 | 0.2424 | |
| GSE77861 | SIGLEC8 | 27181 | 208253_at | -0.0848 | 0.4446 | |
| GSE97050 | SIGLEC8 | 27181 | A_24_P40001 | -0.0539 | 0.7963 | |
| SRP064894 | SIGLEC8 | 27181 | RNAseq | -0.4000 | 0.0979 | |
| SRP133303 | SIGLEC8 | 27181 | RNAseq | 0.0193 | 0.8696 | |
| SRP159526 | SIGLEC8 | 27181 | RNAseq | 0.1920 | 0.6784 | |
| SRP193095 | SIGLEC8 | 27181 | RNAseq | 0.0619 | 0.6398 | |
| SRP219564 | SIGLEC8 | 27181 | RNAseq | 0.3121 | 0.5482 | |
| TCGA | SIGLEC8 | 27181 | RNAseq | -0.1019 | 0.8278 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SIGLEC8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIGLEC8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIGLEC8 | 27181 | 3 | 4 | 23 | |
| GSE20123 | SIGLEC8 | 27181 | 3 | 3 | 24 | |
| GSE43470 | SIGLEC8 | 27181 | 3 | 12 | 28 | |
| GSE46452 | SIGLEC8 | 27181 | 45 | 1 | 13 | |
| GSE47630 | SIGLEC8 | 27181 | 9 | 6 | 25 | |
| GSE54993 | SIGLEC8 | 27181 | 17 | 4 | 49 | |
| GSE54994 | SIGLEC8 | 27181 | 4 | 14 | 35 | |
| GSE60625 | SIGLEC8 | 27181 | 9 | 0 | 2 | |
| GSE74703 | SIGLEC8 | 27181 | 3 | 8 | 25 | |
| GSE74704 | SIGLEC8 | 27181 | 3 | 1 | 16 | |
| TCGA | SIGLEC8 | 27181 | 14 | 19 | 63 |
Total number of gains: 113; Total number of losses: 72; Total Number of normals: 303.
Somatic mutations of SIGLEC8:
Generating mutation plots.
Highly correlated genes for SIGLEC8:
Showing top 20/409 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIGLEC8 | PGC | 0.817535 | 3 | 0 | 3 |
| SIGLEC8 | RAB3IL1 | 0.788598 | 3 | 0 | 3 |
| SIGLEC8 | SCARF2 | 0.768865 | 3 | 0 | 3 |
| SIGLEC8 | WAS | 0.753192 | 3 | 0 | 3 |
| SIGLEC8 | JSRP1 | 0.747313 | 4 | 0 | 4 |
| SIGLEC8 | PPP1R3F | 0.72418 | 3 | 0 | 3 |
| SIGLEC8 | CDH10 | 0.711279 | 3 | 0 | 3 |
| SIGLEC8 | SIX3 | 0.709152 | 4 | 0 | 4 |
| SIGLEC8 | FAM163A | 0.708975 | 4 | 0 | 4 |
| SIGLEC8 | HRC | 0.704258 | 4 | 0 | 3 |
| SIGLEC8 | HMGCLL1 | 0.702269 | 3 | 0 | 3 |
| SIGLEC8 | CGA | 0.700687 | 3 | 0 | 3 |
| SIGLEC8 | CPA5 | 0.693523 | 3 | 0 | 3 |
| SIGLEC8 | FBP2 | 0.693395 | 3 | 0 | 3 |
| SIGLEC8 | HSPA12B | 0.692913 | 3 | 0 | 3 |
| SIGLEC8 | CEMP1 | 0.689043 | 6 | 0 | 5 |
| SIGLEC8 | MC2R | 0.686151 | 3 | 0 | 3 |
| SIGLEC8 | TAS2R7 | 0.686131 | 3 | 0 | 3 |
| SIGLEC8 | AQP5 | 0.679519 | 3 | 0 | 3 |
| SIGLEC8 | C4BPA | 0.678339 | 3 | 0 | 3 |
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