| Full name: kinase suppressor of ras 1 | Alias Symbol: RSU2 | ||
| Type: protein-coding gene | Cytoband: 17q11.2 | ||
| Entrez ID: 8844 | HGNC ID: HGNC:6465 | Ensembl Gene: ENSG00000141068 | OMIM ID: 601132 |
| Drug and gene relationship at DGIdb | |||
KSR1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway | |
| hsa05152 | Tuberculosis |
Expression of KSR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KSR1 | 8844 | 235252_at | -0.5067 | 0.3793 | |
| GSE20347 | KSR1 | 8844 | 213770_at | -0.0558 | 0.4773 | |
| GSE23400 | KSR1 | 8844 | 213770_at | -0.1552 | 0.0033 | |
| GSE26886 | KSR1 | 8844 | 235252_at | -0.9509 | 0.0005 | |
| GSE29001 | KSR1 | 8844 | 213770_at | -0.1734 | 0.3513 | |
| GSE38129 | KSR1 | 8844 | 213770_at | -0.2041 | 0.0209 | |
| GSE45670 | KSR1 | 8844 | 235252_at | -0.0853 | 0.7448 | |
| GSE53622 | KSR1 | 8844 | 10699 | -0.6662 | 0.0000 | |
| GSE53624 | KSR1 | 8844 | 10699 | -0.8368 | 0.0000 | |
| GSE63941 | KSR1 | 8844 | 235252_at | -1.5761 | 0.0034 | |
| GSE77861 | KSR1 | 8844 | 235252_at | -0.5083 | 0.1313 | |
| GSE97050 | KSR1 | 8844 | A_23_P207774 | 0.0631 | 0.8456 | |
| SRP007169 | KSR1 | 8844 | RNAseq | -1.8574 | 0.0000 | |
| SRP008496 | KSR1 | 8844 | RNAseq | -2.1676 | 0.0000 | |
| SRP064894 | KSR1 | 8844 | RNAseq | -1.0235 | 0.0000 | |
| SRP133303 | KSR1 | 8844 | RNAseq | -0.8469 | 0.0000 | |
| SRP159526 | KSR1 | 8844 | RNAseq | -1.6957 | 0.0000 | |
| SRP193095 | KSR1 | 8844 | RNAseq | -0.5872 | 0.0001 | |
| SRP219564 | KSR1 | 8844 | RNAseq | -0.3996 | 0.4502 | |
| TCGA | KSR1 | 8844 | RNAseq | 0.0336 | 0.7119 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by KSR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KSR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KSR1 | 8844 | 8 | 3 | 19 | |
| GSE20123 | KSR1 | 8844 | 7 | 3 | 20 | |
| GSE43470 | KSR1 | 8844 | 0 | 1 | 42 | |
| GSE46452 | KSR1 | 8844 | 33 | 1 | 25 | |
| GSE47630 | KSR1 | 8844 | 7 | 1 | 32 | |
| GSE54993 | KSR1 | 8844 | 2 | 3 | 65 | |
| GSE54994 | KSR1 | 8844 | 7 | 6 | 40 | |
| GSE60625 | KSR1 | 8844 | 4 | 0 | 7 | |
| GSE74703 | KSR1 | 8844 | 0 | 1 | 35 | |
| GSE74704 | KSR1 | 8844 | 6 | 1 | 13 | |
| TCGA | KSR1 | 8844 | 21 | 11 | 64 |
Total number of gains: 95; Total number of losses: 31; Total Number of normals: 362.
Somatic mutations of KSR1:
Generating mutation plots.
Highly correlated genes for KSR1:
Showing top 20/784 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KSR1 | SOX6 | 0.840302 | 3 | 0 | 3 |
| KSR1 | TFF1 | 0.809995 | 3 | 0 | 3 |
| KSR1 | KIF17 | 0.783668 | 3 | 0 | 3 |
| KSR1 | SLC9A5 | 0.75977 | 3 | 0 | 3 |
| KSR1 | C11orf16 | 0.757041 | 4 | 0 | 4 |
| KSR1 | GGT6 | 0.747861 | 7 | 0 | 7 |
| KSR1 | NOS1 | 0.741283 | 4 | 0 | 4 |
| KSR1 | GNAT1 | 0.74045 | 4 | 0 | 4 |
| KSR1 | CPA2 | 0.740359 | 3 | 0 | 3 |
| KSR1 | HECW1 | 0.732415 | 5 | 0 | 5 |
| KSR1 | PSG9 | 0.732415 | 3 | 0 | 3 |
| KSR1 | FOXN3-AS2 | 0.728417 | 4 | 0 | 4 |
| KSR1 | LRTM1 | 0.727965 | 5 | 0 | 5 |
| KSR1 | HBQ1 | 0.727017 | 3 | 0 | 3 |
| KSR1 | HS6ST1 | 0.723427 | 3 | 0 | 3 |
| KSR1 | MC2R | 0.723292 | 3 | 0 | 3 |
| KSR1 | PRAMEF12 | 0.720425 | 4 | 0 | 4 |
| KSR1 | TCP10L | 0.718119 | 4 | 0 | 4 |
| KSR1 | GPD1 | 0.71529 | 4 | 0 | 3 |
| KSR1 | UMOD | 0.713145 | 4 | 0 | 4 |
For details and further investigation, click here
