CLEC4E

 

Full name: C-type lectin domain family 4 member E Alias Symbol: mincle
Type: protein-coding gene Cytoband: 12p13.31
Entrez ID: 26253 HGNC ID: HGNC:14555 Ensembl Gene: ENSG00000166523 OMIM ID: 609962
Drug and gene relationship at DGIdb

 

CLEC4E involved pathways:

KEGG pathway Description View
hsa05152Tuberculosis

 

Expression of CLEC4E:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CLEC4E 26253 222934_s_at 0.6910 0.5574
GSE20347 CLEC4E 26253 219859_at 0.0662 0.5349
GSE23400 CLEC4E 26253 219859_at -0.0294 0.1869
GSE26886 CLEC4E 26253 222934_s_at 0.0559 0.5926
GSE29001 CLEC4E 26253 219859_at -0.0330 0.8875
GSE38129 CLEC4E 26253 219859_at -0.0871 0.2440
GSE45670 CLEC4E 26253 222934_s_at 0.0789 0.5896
GSE53622 CLEC4E 26253 154233 0.5524 0.0032
GSE53624 CLEC4E 26253 154233 0.5094 0.0139
GSE63941 CLEC4E 26253 222934_s_at 0.0628 0.7251
GSE77861 CLEC4E 26253 222934_s_at 0.0481 0.7052
GSE97050 CLEC4E 26253 A_33_P3318509 0.1667 0.4847
SRP064894 CLEC4E 26253 RNAseq 1.2784 0.0028
SRP133303 CLEC4E 26253 RNAseq 0.4338 0.0170
SRP159526 CLEC4E 26253 RNAseq 1.2892 0.0844
SRP193095 CLEC4E 26253 RNAseq 0.5425 0.0003
SRP219564 CLEC4E 26253 RNAseq 0.8725 0.1631
TCGA CLEC4E 26253 RNAseq -0.2008 0.6118

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by CLEC4E expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CLEC4E:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CLEC4E 26253 6 3 21
GSE20123 CLEC4E 26253 6 3 21
GSE43470 CLEC4E 26253 7 3 33
GSE46452 CLEC4E 26253 10 1 48
GSE47630 CLEC4E 26253 12 2 26
GSE54993 CLEC4E 26253 1 10 59
GSE54994 CLEC4E 26253 9 2 42
GSE60625 CLEC4E 26253 0 1 10
GSE74703 CLEC4E 26253 7 2 27
GSE74704 CLEC4E 26253 4 2 14
TCGA CLEC4E 26253 40 6 50

Total number of gains: 102; Total number of losses: 35; Total Number of normals: 351.  

 

Somatic mutations of CLEC4E:

 

Generating mutation plots.

 

Highly correlated genes for CLEC4E:

 

Showing top 20/429 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CLEC4EBCL2A10.736755303
CLEC4EPEG100.699698303
CLEC4ECHST40.695378303
CLEC4EADAM220.687477403
CLEC4ECHST50.675536303
CLEC4ERFPL20.674169604
CLEC4ELAMC30.673873404
CLEC4EFCGR2C0.672886707
CLEC4ENRSN20.670753303
CLEC4EANPEP0.66947303
CLEC4EITGB30.662781404
CLEC4EOR10H10.661784303
CLEC4EKIR3DS10.655252303
CLEC4EGRIN2B0.654741403
CLEC4EFIBCD10.653122303
CLEC4ECYSLTR20.652417606
CLEC4EIFNA170.651868504
CLEC4ERECK0.649496403
CLEC4ESPSB40.647685303
CLEC4EKCNA10.645623504

For details and further investigation, click here