| Full name: Mdm1 nuclear protein | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q15 | ||
| Entrez ID: 56890 | HGNC ID: HGNC:29917 | Ensembl Gene: ENSG00000111554 | OMIM ID: 613813 |
| Drug and gene relationship at DGIdb | |||
Expression of MDM1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MDM1 | 56890 | 213761_at | 0.1796 | 0.7954 | |
| GSE20347 | MDM1 | 56890 | 213761_at | 0.4157 | 0.0623 | |
| GSE23400 | MDM1 | 56890 | 213761_at | 0.3903 | 0.0011 | |
| GSE26886 | MDM1 | 56890 | 213761_at | 0.5661 | 0.0536 | |
| GSE29001 | MDM1 | 56890 | 213761_at | 0.5802 | 0.0855 | |
| GSE38129 | MDM1 | 56890 | 213761_at | 0.4497 | 0.0838 | |
| GSE45670 | MDM1 | 56890 | 213761_at | 0.2122 | 0.2434 | |
| GSE53622 | MDM1 | 56890 | 147604 | 0.3555 | 0.0058 | |
| GSE53624 | MDM1 | 56890 | 147604 | 0.4389 | 0.0000 | |
| GSE63941 | MDM1 | 56890 | 213761_at | 0.4097 | 0.6229 | |
| GSE77861 | MDM1 | 56890 | 213761_at | 0.4320 | 0.1138 | |
| GSE97050 | MDM1 | 56890 | A_23_P105730 | 0.1239 | 0.6254 | |
| SRP007169 | MDM1 | 56890 | RNAseq | 0.5515 | 0.2702 | |
| SRP008496 | MDM1 | 56890 | RNAseq | 0.5329 | 0.1283 | |
| SRP064894 | MDM1 | 56890 | RNAseq | 0.4225 | 0.1367 | |
| SRP133303 | MDM1 | 56890 | RNAseq | 0.3250 | 0.0550 | |
| SRP159526 | MDM1 | 56890 | RNAseq | 0.7607 | 0.0310 | |
| SRP193095 | MDM1 | 56890 | RNAseq | 0.0649 | 0.6314 | |
| SRP219564 | MDM1 | 56890 | RNAseq | 1.1384 | 0.0444 | |
| TCGA | MDM1 | 56890 | RNAseq | 0.0828 | 0.3539 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MDM1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MDM1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MDM1 | 56890 | 6 | 2 | 22 | |
| GSE20123 | MDM1 | 56890 | 6 | 1 | 23 | |
| GSE43470 | MDM1 | 56890 | 5 | 0 | 38 | |
| GSE46452 | MDM1 | 56890 | 13 | 0 | 46 | |
| GSE47630 | MDM1 | 56890 | 10 | 1 | 29 | |
| GSE54993 | MDM1 | 56890 | 0 | 8 | 62 | |
| GSE54994 | MDM1 | 56890 | 7 | 1 | 45 | |
| GSE60625 | MDM1 | 56890 | 0 | 0 | 11 | |
| GSE74703 | MDM1 | 56890 | 5 | 0 | 31 | |
| GSE74704 | MDM1 | 56890 | 5 | 1 | 14 | |
| TCGA | MDM1 | 56890 | 24 | 9 | 63 |
Total number of gains: 81; Total number of losses: 23; Total Number of normals: 384.
Somatic mutations of MDM1:
Generating mutation plots.
Highly correlated genes for MDM1:
Showing top 20/425 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MDM1 | AMMECR1L | 0.743904 | 3 | 0 | 3 |
| MDM1 | LRRC34 | 0.736205 | 3 | 0 | 3 |
| MDM1 | SLC25A33 | 0.723478 | 5 | 0 | 5 |
| MDM1 | FOXO1 | 0.71499 | 3 | 0 | 3 |
| MDM1 | USP31 | 0.708298 | 3 | 0 | 3 |
| MDM1 | TMTC1 | 0.705814 | 3 | 0 | 3 |
| MDM1 | BOD1 | 0.705644 | 3 | 0 | 3 |
| MDM1 | GLIPR1 | 0.702695 | 3 | 0 | 3 |
| MDM1 | EFCAB7 | 0.696821 | 4 | 0 | 4 |
| MDM1 | ZNF829 | 0.695722 | 3 | 0 | 3 |
| MDM1 | SKI | 0.68645 | 3 | 0 | 3 |
| MDM1 | MIS12 | 0.67857 | 4 | 0 | 3 |
| MDM1 | ZNF41 | 0.677583 | 3 | 0 | 3 |
| MDM1 | PACRGL | 0.664706 | 4 | 0 | 3 |
| MDM1 | OTUD7B | 0.663371 | 3 | 0 | 3 |
| MDM1 | TMTC3 | 0.661171 | 3 | 0 | 3 |
| MDM1 | MSI2 | 0.658177 | 4 | 0 | 3 |
| MDM1 | PTTG1IP | 0.657764 | 4 | 0 | 3 |
| MDM1 | COA5 | 0.655216 | 3 | 0 | 3 |
| MDM1 | HAUS1 | 0.65512 | 3 | 0 | 3 |
For details and further investigation, click here
