| Full name: transmembrane O-mannosyltransferase targeting cadherins 3 | Alias Symbol: FLJ90492|SMILE | ||
| Type: protein-coding gene | Cytoband: 12q21.32 | ||
| Entrez ID: 160418 | HGNC ID: HGNC:26899 | Ensembl Gene: ENSG00000139324 | OMIM ID: 617218 |
| Drug and gene relationship at DGIdb | |||
Expression of TMTC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMTC3 | 160418 | 226600_at | 0.1949 | 0.7188 | |
| GSE26886 | TMTC3 | 160418 | 226604_at | 0.5398 | 0.0164 | |
| GSE45670 | TMTC3 | 160418 | 226604_at | 0.0859 | 0.6806 | |
| GSE53622 | TMTC3 | 160418 | 150248 | 0.4919 | 0.0000 | |
| GSE53624 | TMTC3 | 160418 | 73413 | 0.3749 | 0.0001 | |
| GSE63941 | TMTC3 | 160418 | 226600_at | -0.7045 | 0.1916 | |
| GSE77861 | TMTC3 | 160418 | 226600_at | 0.5165 | 0.2024 | |
| GSE97050 | TMTC3 | 160418 | A_24_P918266 | 0.2168 | 0.3637 | |
| SRP007169 | TMTC3 | 160418 | RNAseq | 0.3943 | 0.2585 | |
| SRP008496 | TMTC3 | 160418 | RNAseq | 0.6704 | 0.0101 | |
| SRP064894 | TMTC3 | 160418 | RNAseq | 0.2647 | 0.2883 | |
| SRP133303 | TMTC3 | 160418 | RNAseq | 0.6980 | 0.0030 | |
| SRP159526 | TMTC3 | 160418 | RNAseq | 0.5244 | 0.0814 | |
| SRP193095 | TMTC3 | 160418 | RNAseq | 0.4089 | 0.0912 | |
| SRP219564 | TMTC3 | 160418 | RNAseq | 0.0903 | 0.8314 | |
| TCGA | TMTC3 | 160418 | RNAseq | 0.3118 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TMTC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMTC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMTC3 | 160418 | 3 | 3 | 24 | |
| GSE20123 | TMTC3 | 160418 | 3 | 3 | 24 | |
| GSE43470 | TMTC3 | 160418 | 3 | 1 | 39 | |
| GSE46452 | TMTC3 | 160418 | 9 | 1 | 49 | |
| GSE47630 | TMTC3 | 160418 | 10 | 1 | 29 | |
| GSE54993 | TMTC3 | 160418 | 0 | 6 | 64 | |
| GSE54994 | TMTC3 | 160418 | 7 | 1 | 45 | |
| GSE60625 | TMTC3 | 160418 | 0 | 0 | 11 | |
| GSE74703 | TMTC3 | 160418 | 3 | 1 | 32 | |
| GSE74704 | TMTC3 | 160418 | 1 | 3 | 16 | |
| TCGA | TMTC3 | 160418 | 19 | 10 | 67 |
Total number of gains: 58; Total number of losses: 30; Total Number of normals: 400.
Somatic mutations of TMTC3:
Generating mutation plots.
Highly correlated genes for TMTC3:
Showing top 20/521 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMTC3 | SNAP23 | 0.78937 | 3 | 0 | 3 |
| TMTC3 | C9orf78 | 0.784633 | 3 | 0 | 3 |
| TMTC3 | ZNF200 | 0.781216 | 4 | 0 | 4 |
| TMTC3 | CDK5RAP2 | 0.777046 | 3 | 0 | 3 |
| TMTC3 | DHX40 | 0.766579 | 3 | 0 | 3 |
| TMTC3 | TAS2R19 | 0.76092 | 3 | 0 | 3 |
| TMTC3 | ZNF484 | 0.758258 | 3 | 0 | 3 |
| TMTC3 | GTF3C3 | 0.755066 | 3 | 0 | 3 |
| TMTC3 | MKLN1 | 0.754281 | 3 | 0 | 3 |
| TMTC3 | SMC2 | 0.753987 | 4 | 0 | 3 |
| TMTC3 | ZNHIT6 | 0.752063 | 3 | 0 | 3 |
| TMTC3 | MRPL35 | 0.751989 | 3 | 0 | 3 |
| TMTC3 | MITD1 | 0.748303 | 3 | 0 | 3 |
| TMTC3 | NIPA2 | 0.74708 | 4 | 0 | 4 |
| TMTC3 | ORC4 | 0.741575 | 4 | 0 | 4 |
| TMTC3 | THAP1 | 0.740656 | 3 | 0 | 3 |
| TMTC3 | ZNF267 | 0.735202 | 4 | 0 | 3 |
| TMTC3 | LRIF1 | 0.7348 | 4 | 0 | 4 |
| TMTC3 | ACP1 | 0.733996 | 3 | 0 | 3 |
| TMTC3 | GSR | 0.732979 | 3 | 0 | 3 |
For details and further investigation, click here
