| Full name: transmembrane O-mannosyltransferase targeting cadherins 1 | Alias Symbol: ARG99|OLF|FLJ31400|FLJ41625 | ||
| Type: protein-coding gene | Cytoband: 12p11.22 | ||
| Entrez ID: 83857 | HGNC ID: HGNC:24099 | Ensembl Gene: ENSG00000133687 | OMIM ID: 615855 |
| Drug and gene relationship at DGIdb | |||
Expression of TMTC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMTC1 | 83857 | 226322_at | -0.2598 | 0.8587 | |
| GSE26886 | TMTC1 | 83857 | 226322_at | 2.2698 | 0.0004 | |
| GSE45670 | TMTC1 | 83857 | 226322_at | -1.3908 | 0.0370 | |
| GSE53622 | TMTC1 | 83857 | 116444 | 0.0121 | 0.9536 | |
| GSE53624 | TMTC1 | 83857 | 50430 | -0.2012 | 0.2724 | |
| GSE63941 | TMTC1 | 83857 | 226322_at | -4.7605 | 0.0065 | |
| GSE77861 | TMTC1 | 83857 | 226931_at | 1.7527 | 0.0006 | |
| GSE97050 | TMTC1 | 83857 | A_33_P3249364 | -0.6951 | 0.1449 | |
| SRP007169 | TMTC1 | 83857 | RNAseq | 2.9062 | 0.0001 | |
| SRP008496 | TMTC1 | 83857 | RNAseq | 3.6707 | 0.0000 | |
| SRP064894 | TMTC1 | 83857 | RNAseq | 0.0806 | 0.8306 | |
| SRP133303 | TMTC1 | 83857 | RNAseq | -0.2478 | 0.4364 | |
| SRP159526 | TMTC1 | 83857 | RNAseq | 1.2617 | 0.0030 | |
| SRP193095 | TMTC1 | 83857 | RNAseq | 1.5073 | 0.0000 | |
| SRP219564 | TMTC1 | 83857 | RNAseq | 0.0883 | 0.9003 | |
| TCGA | TMTC1 | 83857 | RNAseq | -0.1838 | 0.3491 |
Upregulated datasets: 6; Downregulated datasets: 2.
Survival by TMTC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMTC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMTC1 | 83857 | 12 | 1 | 17 | |
| GSE20123 | TMTC1 | 83857 | 12 | 1 | 17 | |
| GSE43470 | TMTC1 | 83857 | 8 | 3 | 32 | |
| GSE46452 | TMTC1 | 83857 | 10 | 1 | 48 | |
| GSE47630 | TMTC1 | 83857 | 13 | 0 | 27 | |
| GSE54993 | TMTC1 | 83857 | 0 | 9 | 61 | |
| GSE54994 | TMTC1 | 83857 | 9 | 2 | 42 | |
| GSE60625 | TMTC1 | 83857 | 0 | 1 | 10 | |
| GSE74703 | TMTC1 | 83857 | 7 | 2 | 27 | |
| GSE74704 | TMTC1 | 83857 | 6 | 1 | 13 | |
| TCGA | TMTC1 | 83857 | 43 | 6 | 47 |
Total number of gains: 120; Total number of losses: 27; Total Number of normals: 341.
Somatic mutations of TMTC1:
Generating mutation plots.
Highly correlated genes for TMTC1:
Showing top 20/924 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMTC1 | CEP290 | 0.838852 | 3 | 0 | 3 |
| TMTC1 | LRRC23 | 0.821405 | 4 | 0 | 4 |
| TMTC1 | RAD23A | 0.817371 | 3 | 0 | 3 |
| TMTC1 | MAP2K5 | 0.807292 | 3 | 0 | 3 |
| TMTC1 | PTGFRN | 0.800836 | 3 | 0 | 3 |
| TMTC1 | NMT1 | 0.798416 | 3 | 0 | 3 |
| TMTC1 | ATP2B4 | 0.797188 | 3 | 0 | 3 |
| TMTC1 | AP2B1 | 0.794059 | 3 | 0 | 3 |
| TMTC1 | ITGAV | 0.792776 | 3 | 0 | 3 |
| TMTC1 | METTL5 | 0.78767 | 3 | 0 | 3 |
| TMTC1 | TRRAP | 0.786998 | 3 | 0 | 3 |
| TMTC1 | DNAH14 | 0.78548 | 3 | 0 | 3 |
| TMTC1 | DYNC2LI1 | 0.785173 | 3 | 0 | 3 |
| TMTC1 | PRPS1 | 0.776901 | 4 | 0 | 4 |
| TMTC1 | PRTFDC1 | 0.773343 | 3 | 0 | 3 |
| TMTC1 | EMILIN2 | 0.767623 | 3 | 0 | 3 |
| TMTC1 | RNASEH2C | 0.766621 | 3 | 0 | 3 |
| TMTC1 | ABCC4 | 0.766589 | 4 | 0 | 4 |
| TMTC1 | PAK1 | 0.76655 | 4 | 0 | 4 |
| TMTC1 | ZDHHC4 | 0.76645 | 4 | 0 | 4 |
For details and further investigation, click here
