FOXO1

 

Full name: forkhead box O1 Alias Symbol: FKH1
Type: protein-coding gene Cytoband: 13q14.11
Entrez ID: 2308 HGNC ID: HGNC:3819 Ensembl Gene: ENSG00000150907 OMIM ID: 136533
Drug and gene relationship at DGIdb

 

FOXO1 involved pathways:

KEGG pathway Description View
hsa04068FoxO signaling pathway
hsa04152AMPK signaling pathway
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04910Insulin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04922Glucagon signaling pathway
hsa04931Insulin resistance
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05200Pathways in cancer
hsa05215Prostate cancer

 

Expression of FOXO1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FOXO1 2308 202723_s_at 0.0178 0.9898
GSE20347 FOXO1 2308 202724_s_at 0.0284 0.9096
GSE23400 FOXO1 2308 202723_s_at 0.1183 0.2614
GSE26886 FOXO1 2308 202724_s_at 1.4505 0.0000
GSE29001 FOXO1 2308 202724_s_at 0.0883 0.8254
GSE38129 FOXO1 2308 202724_s_at -0.1527 0.5243
GSE45670 FOXO1 2308 202724_s_at -0.4655 0.0224
GSE53622 FOXO1 2308 147203 -0.0943 0.3106
GSE53624 FOXO1 2308 147203 -0.1079 0.1437
GSE63941 FOXO1 2308 202724_s_at 1.4157 0.0361
GSE77861 FOXO1 2308 202724_s_at 0.7276 0.0341
GSE97050 FOXO1 2308 A_24_P22079 0.0594 0.7673
SRP007169 FOXO1 2308 RNAseq 1.2301 0.0023
SRP008496 FOXO1 2308 RNAseq 1.5895 0.0000
SRP064894 FOXO1 2308 RNAseq 0.2152 0.4613
SRP133303 FOXO1 2308 RNAseq 0.3665 0.2157
SRP159526 FOXO1 2308 RNAseq -0.3232 0.2885
SRP193095 FOXO1 2308 RNAseq 0.3628 0.0132
SRP219564 FOXO1 2308 RNAseq -0.0162 0.9740
TCGA FOXO1 2308 RNAseq -0.1818 0.0134

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by FOXO1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FOXO1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FOXO1 2308 0 15 15
GSE20123 FOXO1 2308 0 14 16
GSE43470 FOXO1 2308 3 13 27
GSE46452 FOXO1 2308 0 33 26
GSE47630 FOXO1 2308 2 27 11
GSE54993 FOXO1 2308 12 2 56
GSE54994 FOXO1 2308 1 17 35
GSE60625 FOXO1 2308 0 3 8
GSE74703 FOXO1 2308 3 10 23
GSE74704 FOXO1 2308 0 11 9
TCGA FOXO1 2308 7 40 49

Total number of gains: 28; Total number of losses: 185; Total Number of normals: 275.  

 

Somatic mutations of FOXO1:

 

Generating mutation plots.

 

Highly correlated genes for FOXO1:

 

Showing top 20/211 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FOXO1CHERP0.74578303
FOXO1DSG20.735003303
FOXO1MDM10.71499303
FOXO1TRRAP0.71241303
FOXO1NTPCR0.710898303
FOXO1GABRR10.686769303
FOXO1CDCA7L0.683188303
FOXO1SLFN50.682631303
FOXO1DVL20.670005403
FOXO1XCL10.668768303
FOXO1ZKSCAN80.665022303
FOXO1KMT2E0.659668303
FOXO1PFN20.655177303
FOXO1DHRSX0.652008303
FOXO1WDR810.646938404
FOXO1EFNA10.645591303
FOXO1BPTF0.643537303
FOXO1WDR660.642893303
FOXO1KCNAB20.636766303
FOXO1SAT20.636302403

For details and further investigation, click here