| Full name: muscle RAS oncogene homolog | Alias Symbol: M-RAs|R-RAS3|RRAS3 | ||
| Type: protein-coding gene | Cytoband: 3q22.3 | ||
| Entrez ID: 22808 | HGNC ID: HGNC:7227 | Ensembl Gene: ENSG00000158186 | OMIM ID: 608435 |
| Drug and gene relationship at DGIdb | |||
MRAS involved pathways:
Expression of MRAS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRAS | 22808 | 225185_at | 0.4905 | 0.4372 | |
| GSE20347 | MRAS | 22808 | 206538_at | -0.0380 | 0.6507 | |
| GSE23400 | MRAS | 22808 | 206538_at | -0.0714 | 0.0142 | |
| GSE26886 | MRAS | 22808 | 225185_at | 0.7042 | 0.0152 | |
| GSE29001 | MRAS | 22808 | 206538_at | 0.0991 | 0.5296 | |
| GSE38129 | MRAS | 22808 | 206538_at | -0.2287 | 0.0560 | |
| GSE45670 | MRAS | 22808 | 225185_at | -0.3862 | 0.0656 | |
| GSE53622 | MRAS | 22808 | 58890 | 0.1902 | 0.2885 | |
| GSE53624 | MRAS | 22808 | 58890 | 0.4255 | 0.0081 | |
| GSE63941 | MRAS | 22808 | 225185_at | -3.2439 | 0.0014 | |
| GSE77861 | MRAS | 22808 | 206538_at | -0.0228 | 0.8522 | |
| GSE97050 | MRAS | 22808 | A_24_P88850 | -0.2033 | 0.5487 | |
| SRP007169 | MRAS | 22808 | RNAseq | 2.7921 | 0.0001 | |
| SRP008496 | MRAS | 22808 | RNAseq | 3.0259 | 0.0000 | |
| SRP064894 | MRAS | 22808 | RNAseq | 0.8627 | 0.0059 | |
| SRP133303 | MRAS | 22808 | RNAseq | 0.5472 | 0.0761 | |
| SRP159526 | MRAS | 22808 | RNAseq | 0.6118 | 0.0339 | |
| SRP193095 | MRAS | 22808 | RNAseq | 1.4471 | 0.0000 | |
| SRP219564 | MRAS | 22808 | RNAseq | -0.0878 | 0.9128 | |
| TCGA | MRAS | 22808 | RNAseq | -0.2949 | 0.0183 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by MRAS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRAS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRAS | 22808 | 17 | 0 | 13 | |
| GSE20123 | MRAS | 22808 | 17 | 0 | 13 | |
| GSE43470 | MRAS | 22808 | 22 | 0 | 21 | |
| GSE46452 | MRAS | 22808 | 15 | 4 | 40 | |
| GSE47630 | MRAS | 22808 | 18 | 3 | 19 | |
| GSE54993 | MRAS | 22808 | 2 | 9 | 59 | |
| GSE54994 | MRAS | 22808 | 32 | 1 | 20 | |
| GSE60625 | MRAS | 22808 | 0 | 6 | 5 | |
| GSE74703 | MRAS | 22808 | 19 | 0 | 17 | |
| GSE74704 | MRAS | 22808 | 11 | 0 | 9 | |
| TCGA | MRAS | 22808 | 62 | 4 | 30 |
Total number of gains: 215; Total number of losses: 27; Total Number of normals: 246.
Somatic mutations of MRAS:
Generating mutation plots.
Highly correlated genes for MRAS:
Showing top 20/950 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRAS | TNFSF12 | 0.773523 | 3 | 0 | 3 |
| MRAS | LRRC14 | 0.771459 | 3 | 0 | 3 |
| MRAS | SMPD1 | 0.770043 | 3 | 0 | 3 |
| MRAS | NFIX | 0.764006 | 3 | 0 | 3 |
| MRAS | STARD9 | 0.755259 | 3 | 0 | 3 |
| MRAS | ZSCAN21 | 0.750316 | 3 | 0 | 3 |
| MRAS | KLHL21 | 0.747523 | 3 | 0 | 3 |
| MRAS | YTHDF3 | 0.746458 | 3 | 0 | 3 |
| MRAS | ZFAND3 | 0.743777 | 3 | 0 | 3 |
| MRAS | ARMCX2 | 0.736536 | 6 | 0 | 6 |
| MRAS | ZNF322 | 0.728916 | 3 | 0 | 3 |
| MRAS | SKI | 0.722728 | 5 | 0 | 4 |
| MRAS | ASPA | 0.719619 | 4 | 0 | 3 |
| MRAS | GNG2 | 0.718347 | 4 | 0 | 4 |
| MRAS | KCTD7 | 0.716498 | 3 | 0 | 3 |
| MRAS | MAPKAPK2 | 0.716292 | 4 | 0 | 4 |
| MRAS | TCEAL6 | 0.715052 | 3 | 0 | 3 |
| MRAS | ANXA6 | 0.714615 | 9 | 0 | 8 |
| MRAS | ANKRD10 | 0.713459 | 3 | 0 | 3 |
| MRAS | OLFML3 | 0.713279 | 7 | 0 | 7 |
For details and further investigation, click here
