| Full name: kelch like family member 21 | Alias Symbol: KIAA0469 | ||
| Type: protein-coding gene | Cytoband: 1p36.31 | ||
| Entrez ID: 9903 | HGNC ID: HGNC:29041 | Ensembl Gene: ENSG00000162413 | OMIM ID: 616262 |
| Drug and gene relationship at DGIdb | |||
Expression of KLHL21:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLHL21 | 9903 | 203068_at | 0.2497 | 0.7346 | |
| GSE20347 | KLHL21 | 9903 | 203068_at | 0.2444 | 0.1505 | |
| GSE23400 | KLHL21 | 9903 | 203068_at | 0.0406 | 0.5625 | |
| GSE26886 | KLHL21 | 9903 | 203068_at | 0.7676 | 0.0171 | |
| GSE29001 | KLHL21 | 9903 | 203068_at | 0.0746 | 0.7734 | |
| GSE38129 | KLHL21 | 9903 | 203068_at | 0.0944 | 0.5627 | |
| GSE45670 | KLHL21 | 9903 | 203068_at | -0.0990 | 0.6289 | |
| GSE53622 | KLHL21 | 9903 | 16491 | -0.4855 | 0.0000 | |
| GSE53624 | KLHL21 | 9903 | 16491 | -0.1582 | 0.1443 | |
| GSE63941 | KLHL21 | 9903 | 203068_at | -0.9694 | 0.0983 | |
| GSE77861 | KLHL21 | 9903 | 203068_at | 0.1063 | 0.7525 | |
| GSE97050 | KLHL21 | 9903 | A_23_P341223 | -0.5675 | 0.0986 | |
| SRP007169 | KLHL21 | 9903 | RNAseq | -1.1202 | 0.0026 | |
| SRP008496 | KLHL21 | 9903 | RNAseq | -1.1419 | 0.0000 | |
| SRP064894 | KLHL21 | 9903 | RNAseq | -0.6114 | 0.0021 | |
| SRP133303 | KLHL21 | 9903 | RNAseq | -0.1225 | 0.6468 | |
| SRP159526 | KLHL21 | 9903 | RNAseq | -0.6367 | 0.0069 | |
| SRP193095 | KLHL21 | 9903 | RNAseq | 0.1920 | 0.2933 | |
| SRP219564 | KLHL21 | 9903 | RNAseq | -0.5746 | 0.0081 | |
| TCGA | KLHL21 | 9903 | RNAseq | 0.0115 | 0.8223 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by KLHL21 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLHL21:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLHL21 | 9903 | 3 | 6 | 21 | |
| GSE20123 | KLHL21 | 9903 | 3 | 5 | 22 | |
| GSE43470 | KLHL21 | 9903 | 6 | 5 | 32 | |
| GSE46452 | KLHL21 | 9903 | 7 | 1 | 51 | |
| GSE47630 | KLHL21 | 9903 | 8 | 4 | 28 | |
| GSE54993 | KLHL21 | 9903 | 3 | 2 | 65 | |
| GSE54994 | KLHL21 | 9903 | 14 | 3 | 36 | |
| GSE60625 | KLHL21 | 9903 | 0 | 0 | 11 | |
| GSE74703 | KLHL21 | 9903 | 5 | 3 | 28 | |
| GSE74704 | KLHL21 | 9903 | 3 | 0 | 17 | |
| TCGA | KLHL21 | 9903 | 12 | 22 | 62 |
Total number of gains: 64; Total number of losses: 51; Total Number of normals: 373.
Somatic mutations of KLHL21:
Generating mutation plots.
Highly correlated genes for KLHL21:
Showing top 20/243 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLHL21 | RCBTB1 | 0.776712 | 3 | 0 | 3 |
| KLHL21 | MICU1 | 0.763108 | 3 | 0 | 3 |
| KLHL21 | ZNF473 | 0.753242 | 3 | 0 | 3 |
| KLHL21 | TSNARE1 | 0.750694 | 4 | 0 | 4 |
| KLHL21 | MRAS | 0.747523 | 3 | 0 | 3 |
| KLHL21 | ASB2 | 0.73446 | 3 | 0 | 3 |
| KLHL21 | DZIP1L | 0.730456 | 3 | 0 | 3 |
| KLHL21 | ZNF32 | 0.729106 | 3 | 0 | 3 |
| KLHL21 | MGAT4B | 0.725503 | 3 | 0 | 3 |
| KLHL21 | PTPN21 | 0.72486 | 3 | 0 | 3 |
| KLHL21 | CCP110 | 0.724506 | 3 | 0 | 3 |
| KLHL21 | ZNF136 | 0.719905 | 3 | 0 | 3 |
| KLHL21 | SH2B3 | 0.717975 | 3 | 0 | 3 |
| KLHL21 | HRH1 | 0.713227 | 3 | 0 | 3 |
| KLHL21 | ANKRD17 | 0.712893 | 3 | 0 | 3 |
| KLHL21 | IFIT5 | 0.71288 | 3 | 0 | 3 |
| KLHL21 | SGTB | 0.70273 | 3 | 0 | 3 |
| KLHL21 | ATP9A | 0.700004 | 4 | 0 | 3 |
| KLHL21 | CCDC93 | 0.697848 | 4 | 0 | 4 |
| KLHL21 | ZFP90 | 0.695994 | 3 | 0 | 3 |
For details and further investigation, click here
