| Full name: MAPK activated protein kinase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 9261 | HGNC ID: HGNC:6887 | Ensembl Gene: ENSG00000162889 | OMIM ID: 602006 |
| Drug and gene relationship at DGIdb | |||
MAPKAPK2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04370 | VEGF signaling pathway | |
| hsa04722 | Neurotrophin signaling pathway |
Expression of MAPKAPK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAPKAPK2 | 9261 | 201460_at | 0.8010 | 0.0541 | |
| GSE20347 | MAPKAPK2 | 9261 | 201460_at | 0.4372 | 0.0004 | |
| GSE23400 | MAPKAPK2 | 9261 | 201460_at | 0.3163 | 0.0000 | |
| GSE26886 | MAPKAPK2 | 9261 | 201460_at | 0.4834 | 0.0238 | |
| GSE29001 | MAPKAPK2 | 9261 | 201460_at | 0.3645 | 0.1420 | |
| GSE38129 | MAPKAPK2 | 9261 | 201460_at | 0.3917 | 0.0000 | |
| GSE45670 | MAPKAPK2 | 9261 | 201460_at | 0.3079 | 0.0083 | |
| GSE53622 | MAPKAPK2 | 9261 | 38831 | 0.3594 | 0.0000 | |
| GSE53624 | MAPKAPK2 | 9261 | 38831 | 0.4444 | 0.0000 | |
| GSE63941 | MAPKAPK2 | 9261 | 201460_at | -0.5496 | 0.0191 | |
| GSE77861 | MAPKAPK2 | 9261 | 201460_at | 0.3756 | 0.0054 | |
| GSE97050 | MAPKAPK2 | 9261 | A_23_P201483 | 0.4459 | 0.2688 | |
| SRP007169 | MAPKAPK2 | 9261 | RNAseq | -0.6665 | 0.0385 | |
| SRP008496 | MAPKAPK2 | 9261 | RNAseq | -0.6446 | 0.0030 | |
| SRP064894 | MAPKAPK2 | 9261 | RNAseq | 0.3394 | 0.0439 | |
| SRP133303 | MAPKAPK2 | 9261 | RNAseq | 0.5578 | 0.0004 | |
| SRP159526 | MAPKAPK2 | 9261 | RNAseq | 0.4964 | 0.0403 | |
| SRP193095 | MAPKAPK2 | 9261 | RNAseq | 0.4890 | 0.0001 | |
| SRP219564 | MAPKAPK2 | 9261 | RNAseq | 0.1538 | 0.5027 | |
| TCGA | MAPKAPK2 | 9261 | RNAseq | -0.0411 | 0.3264 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MAPKAPK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAPKAPK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAPKAPK2 | 9261 | 11 | 0 | 19 | |
| GSE20123 | MAPKAPK2 | 9261 | 11 | 0 | 19 | |
| GSE43470 | MAPKAPK2 | 9261 | 7 | 0 | 36 | |
| GSE46452 | MAPKAPK2 | 9261 | 3 | 1 | 55 | |
| GSE47630 | MAPKAPK2 | 9261 | 14 | 0 | 26 | |
| GSE54993 | MAPKAPK2 | 9261 | 0 | 6 | 64 | |
| GSE54994 | MAPKAPK2 | 9261 | 14 | 0 | 39 | |
| GSE60625 | MAPKAPK2 | 9261 | 0 | 0 | 11 | |
| GSE74703 | MAPKAPK2 | 9261 | 7 | 0 | 29 | |
| GSE74704 | MAPKAPK2 | 9261 | 5 | 0 | 15 | |
| TCGA | MAPKAPK2 | 9261 | 44 | 4 | 48 |
Total number of gains: 116; Total number of losses: 11; Total Number of normals: 361.
Somatic mutations of MAPKAPK2:
Generating mutation plots.
Highly correlated genes for MAPKAPK2:
Showing top 20/1075 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAPKAPK2 | DYRK2 | 0.797422 | 3 | 0 | 3 |
| MAPKAPK2 | TMTC4 | 0.790654 | 3 | 0 | 3 |
| MAPKAPK2 | PRR12 | 0.753817 | 3 | 0 | 3 |
| MAPKAPK2 | PIF1 | 0.752622 | 3 | 0 | 3 |
| MAPKAPK2 | SLC35B3 | 0.746884 | 3 | 0 | 3 |
| MAPKAPK2 | SLC39A3 | 0.743495 | 4 | 0 | 4 |
| MAPKAPK2 | PACS1 | 0.742162 | 5 | 0 | 4 |
| MAPKAPK2 | RAVER1 | 0.731439 | 4 | 0 | 4 |
| MAPKAPK2 | RILPL1 | 0.724121 | 3 | 0 | 3 |
| MAPKAPK2 | BAHD1 | 0.724044 | 3 | 0 | 3 |
| MAPKAPK2 | TRIM47 | 0.719894 | 3 | 0 | 3 |
| MAPKAPK2 | MRAS | 0.716292 | 4 | 0 | 4 |
| MAPKAPK2 | SH3RF3 | 0.711488 | 3 | 0 | 3 |
| MAPKAPK2 | EXOC6 | 0.707972 | 4 | 0 | 3 |
| MAPKAPK2 | TEX10 | 0.704637 | 4 | 0 | 3 |
| MAPKAPK2 | DROSHA | 0.703326 | 5 | 0 | 4 |
| MAPKAPK2 | SMCR8 | 0.702899 | 5 | 0 | 4 |
| MAPKAPK2 | KATNA1 | 0.702051 | 3 | 0 | 3 |
| MAPKAPK2 | NIN | 0.699443 | 3 | 0 | 3 |
| MAPKAPK2 | ZNF579 | 0.696095 | 4 | 0 | 4 |
For details and further investigation, click here
