LRRC14

 

Full name: leucine rich repeat containing 14 Alias Symbol: KIAA0014|LRRC14A
Type: protein-coding gene Cytoband: 8q24.3
Entrez ID: 9684 HGNC ID: HGNC:20419 Ensembl Gene: ENSG00000160959 OMIM ID: 
Drug and gene relationship at DGIdb

 

Expression of LRRC14:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 LRRC14 9684 32062_at 0.1899 0.5355
GSE20347 LRRC14 9684 32062_at 0.1849 0.0265
GSE23400 LRRC14 9684 203495_at 0.0601 0.1200
GSE26886 LRRC14 9684 203495_at 0.9582 0.0000
GSE29001 LRRC14 9684 203495_at 0.4408 0.0523
GSE38129 LRRC14 9684 32062_at 0.1393 0.0258
GSE45670 LRRC14 9684 32062_at 0.0773 0.5985
GSE53622 LRRC14 9684 34025 0.1156 0.0790
GSE53624 LRRC14 9684 34025 0.4298 0.0000
GSE63941 LRRC14 9684 32062_at -0.0085 0.9820
GSE77861 LRRC14 9684 203495_at 0.1830 0.1794
GSE97050 LRRC14 9684 A_24_P363745 0.0896 0.7992
SRP007169 LRRC14 9684 RNAseq -0.6880 0.1132
SRP008496 LRRC14 9684 RNAseq -0.2639 0.4179
SRP064894 LRRC14 9684 RNAseq 0.7266 0.0010
SRP133303 LRRC14 9684 RNAseq -0.3547 0.0651
SRP159526 LRRC14 9684 RNAseq 0.2546 0.3584
SRP193095 LRRC14 9684 RNAseq 0.4073 0.0014
SRP219564 LRRC14 9684 RNAseq 0.3962 0.4114
TCGA LRRC14 9684 RNAseq 0.0723 0.1602

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by LRRC14 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of LRRC14:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 LRRC14 9684 17 1 12
GSE20123 LRRC14 9684 17 1 12
GSE43470 LRRC14 9684 16 2 25
GSE46452 LRRC14 9684 28 0 31
GSE47630 LRRC14 9684 25 1 14
GSE54993 LRRC14 9684 0 25 45
GSE54994 LRRC14 9684 39 1 13
GSE60625 LRRC14 9684 3 4 4
GSE74703 LRRC14 9684 14 1 21
GSE74704 LRRC14 9684 10 0 10
TCGA LRRC14 9684 63 2 31

Total number of gains: 232; Total number of losses: 38; Total Number of normals: 218.  

 

Somatic mutations of LRRC14:

 

Generating mutation plots.

 

Highly correlated genes for LRRC14:

 

Showing top 20/874 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
LRRC14RNF1300.790767404
LRRC14BHLHE410.775854303
LRRC14COMMD70.77236404
LRRC14MRAS0.771459303
LRRC14BBX0.750698303
LRRC14CAMTA10.750566303
LRRC14GZF10.745775403
LRRC14HEYL0.742359303
LRRC14BHLHB90.734551404
LRRC14PET1170.732757303
LRRC14WDR810.732316404
LRRC14AGK0.730496303
LRRC14HMGN20.728922303
LRRC14ATP11C0.727896303
LRRC14CASK0.727885303
LRRC14ZNF2510.726516404
LRRC14RGS10.725141303
LRRC14TNS30.722827303
LRRC14FTO0.721893404
LRRC14MED130.716568303

For details and further investigation, click here