| Full name: aspartoacylase | Alias Symbol: ASP|ACY2 | ||
| Type: protein-coding gene | Cytoband: 17p13.2 | ||
| Entrez ID: 443 | HGNC ID: HGNC:756 | Ensembl Gene: ENSG00000108381 | OMIM ID: 608034 |
| Drug and gene relationship at DGIdb | |||
Expression of ASPA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ASPA | 443 | 206030_at | -2.4684 | 0.0155 | |
| GSE20347 | ASPA | 443 | 206030_at | -0.3477 | 0.0000 | |
| GSE23400 | ASPA | 443 | 206030_at | -0.4530 | 0.0000 | |
| GSE26886 | ASPA | 443 | 206030_at | -0.4871 | 0.0273 | |
| GSE29001 | ASPA | 443 | 206030_at | -1.5571 | 0.0001 | |
| GSE38129 | ASPA | 443 | 206030_at | -1.0803 | 0.0010 | |
| GSE45670 | ASPA | 443 | 206030_at | -3.0958 | 0.0000 | |
| GSE53622 | ASPA | 443 | 21755 | -3.3253 | 0.0000 | |
| GSE53624 | ASPA | 443 | 21755 | -3.1979 | 0.0000 | |
| GSE63941 | ASPA | 443 | 206030_at | -4.0992 | 0.0000 | |
| GSE77861 | ASPA | 443 | 228807_at | -0.1613 | 0.1449 | |
| GSE97050 | ASPA | 443 | A_23_P164436 | -1.1461 | 0.0850 | |
| SRP064894 | ASPA | 443 | RNAseq | -1.3370 | 0.0001 | |
| SRP133303 | ASPA | 443 | RNAseq | -0.0846 | 0.4550 | |
| SRP159526 | ASPA | 443 | RNAseq | -1.7462 | 0.0000 | |
| SRP193095 | ASPA | 443 | RNAseq | 0.1823 | 0.2041 | |
| SRP219564 | ASPA | 443 | RNAseq | -0.4420 | 0.5324 | |
| TCGA | ASPA | 443 | RNAseq | -2.8507 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by ASPA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ASPA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ASPA | 443 | 5 | 3 | 22 | |
| GSE20123 | ASPA | 443 | 5 | 4 | 21 | |
| GSE43470 | ASPA | 443 | 1 | 6 | 36 | |
| GSE46452 | ASPA | 443 | 34 | 1 | 24 | |
| GSE47630 | ASPA | 443 | 7 | 1 | 32 | |
| GSE54993 | ASPA | 443 | 4 | 3 | 63 | |
| GSE54994 | ASPA | 443 | 5 | 9 | 39 | |
| GSE60625 | ASPA | 443 | 4 | 0 | 7 | |
| GSE74703 | ASPA | 443 | 1 | 3 | 32 | |
| GSE74704 | ASPA | 443 | 3 | 2 | 15 | |
| TCGA | ASPA | 443 | 17 | 21 | 58 |
Total number of gains: 86; Total number of losses: 53; Total Number of normals: 349.
Somatic mutations of ASPA:
Generating mutation plots.
Highly correlated genes for ASPA:
Showing top 20/1710 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ASPA | CLEC3B | 0.9077 | 3 | 0 | 3 |
| ASPA | LINC01082 | 0.895327 | 5 | 0 | 5 |
| ASPA | SORCS1 | 0.883861 | 4 | 0 | 4 |
| ASPA | MRVI1 | 0.88119 | 6 | 0 | 6 |
| ASPA | ABCA8 | 0.866686 | 11 | 0 | 11 |
| ASPA | CYP21A2 | 0.866347 | 3 | 0 | 3 |
| ASPA | SYNPO2 | 0.857513 | 6 | 0 | 6 |
| ASPA | LRRN4CL | 0.855488 | 6 | 0 | 6 |
| ASPA | RBPMS2 | 0.849043 | 5 | 0 | 5 |
| ASPA | MYOCD | 0.844642 | 6 | 0 | 6 |
| ASPA | ZNF407 | 0.842238 | 3 | 0 | 3 |
| ASPA | FENDRR | 0.842051 | 5 | 0 | 5 |
| ASPA | ANGPTL1 | 0.837223 | 7 | 0 | 6 |
| ASPA | NEGR1 | 0.836649 | 7 | 0 | 7 |
| ASPA | C1QTNF7 | 0.831161 | 6 | 0 | 6 |
| ASPA | NEXN | 0.829853 | 6 | 0 | 6 |
| ASPA | RSPO2 | 0.827865 | 3 | 0 | 3 |
| ASPA | TMEM100 | 0.826713 | 10 | 0 | 10 |
| ASPA | NLGN4Y | 0.825137 | 3 | 0 | 3 |
| ASPA | RAB9B | 0.82367 | 6 | 0 | 6 |
For details and further investigation, click here
