| Full name: myosin light chain 6B | Alias Symbol: MLC1SA | ||
| Type: protein-coding gene | Cytoband: 12q13.2 | ||
| Entrez ID: 140465 | HGNC ID: HGNC:29823 | Ensembl Gene: ENSG00000196465 | OMIM ID: 609930 |
| Drug and gene relationship at DGIdb | |||
MYL6B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04270 | Vascular smooth muscle contraction | |
| hsa04921 | Oxytocin signaling pathway |
Expression of MYL6B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MYL6B | 140465 | 204173_at | -0.0296 | 0.9452 | |
| GSE20347 | MYL6B | 140465 | 204173_at | 0.1322 | 0.3279 | |
| GSE23400 | MYL6B | 140465 | 204173_at | 0.2434 | 0.0004 | |
| GSE26886 | MYL6B | 140465 | 204173_at | 0.9557 | 0.0003 | |
| GSE29001 | MYL6B | 140465 | 204173_at | 0.2393 | 0.3626 | |
| GSE38129 | MYL6B | 140465 | 204173_at | 0.2797 | 0.0141 | |
| GSE45670 | MYL6B | 140465 | 204173_at | -0.0549 | 0.7744 | |
| GSE53622 | MYL6B | 140465 | 26994 | 0.0581 | 0.4374 | |
| GSE53624 | MYL6B | 140465 | 26994 | 0.2091 | 0.0002 | |
| GSE63941 | MYL6B | 140465 | 204173_at | -0.4945 | 0.2868 | |
| GSE77861 | MYL6B | 140465 | 204173_at | -0.3839 | 0.1487 | |
| GSE97050 | MYL6B | 140465 | A_23_P2223 | -0.0601 | 0.8657 | |
| SRP007169 | MYL6B | 140465 | RNAseq | -0.4359 | 0.2301 | |
| SRP008496 | MYL6B | 140465 | RNAseq | -0.6576 | 0.0103 | |
| SRP064894 | MYL6B | 140465 | RNAseq | 0.9912 | 0.0115 | |
| SRP133303 | MYL6B | 140465 | RNAseq | -0.0080 | 0.9633 | |
| SRP159526 | MYL6B | 140465 | RNAseq | 0.4103 | 0.3718 | |
| SRP193095 | MYL6B | 140465 | RNAseq | -0.0754 | 0.6345 | |
| SRP219564 | MYL6B | 140465 | RNAseq | 0.4471 | 0.2553 | |
| TCGA | MYL6B | 140465 | RNAseq | 0.2418 | 0.0061 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MYL6B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MYL6B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MYL6B | 140465 | 7 | 2 | 21 | |
| GSE20123 | MYL6B | 140465 | 7 | 1 | 22 | |
| GSE43470 | MYL6B | 140465 | 4 | 0 | 39 | |
| GSE46452 | MYL6B | 140465 | 8 | 1 | 50 | |
| GSE47630 | MYL6B | 140465 | 10 | 2 | 28 | |
| GSE54993 | MYL6B | 140465 | 0 | 5 | 65 | |
| GSE54994 | MYL6B | 140465 | 4 | 1 | 48 | |
| GSE60625 | MYL6B | 140465 | 0 | 0 | 11 | |
| GSE74703 | MYL6B | 140465 | 4 | 0 | 32 | |
| GSE74704 | MYL6B | 140465 | 4 | 1 | 15 | |
| TCGA | MYL6B | 140465 | 14 | 10 | 72 |
Total number of gains: 62; Total number of losses: 23; Total Number of normals: 403.
Somatic mutations of MYL6B:
Generating mutation plots.
Highly correlated genes for MYL6B:
Showing top 20/198 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MYL6B | MGAT3 | 0.761363 | 3 | 0 | 3 |
| MYL6B | WDR86 | 0.751828 | 3 | 0 | 3 |
| MYL6B | SGCB | 0.743978 | 3 | 0 | 3 |
| MYL6B | TERF1 | 0.738143 | 3 | 0 | 3 |
| MYL6B | ZNF791 | 0.738009 | 3 | 0 | 3 |
| MYL6B | ACP6 | 0.722161 | 3 | 0 | 3 |
| MYL6B | WDR13 | 0.721215 | 3 | 0 | 3 |
| MYL6B | FRA10AC1 | 0.719979 | 3 | 0 | 3 |
| MYL6B | RSF1 | 0.719494 | 3 | 0 | 3 |
| MYL6B | ZSCAN21 | 0.713897 | 3 | 0 | 3 |
| MYL6B | FAM200B | 0.712821 | 4 | 0 | 3 |
| MYL6B | INPP5B | 0.710402 | 3 | 0 | 3 |
| MYL6B | RBM4 | 0.710111 | 3 | 0 | 3 |
| MYL6B | DNAJC8 | 0.70952 | 3 | 0 | 3 |
| MYL6B | PAIP1 | 0.708891 | 3 | 0 | 3 |
| MYL6B | ZNF805 | 0.708467 | 3 | 0 | 3 |
| MYL6B | UXT | 0.703439 | 4 | 0 | 3 |
| MYL6B | SLC45A4 | 0.702864 | 3 | 0 | 3 |
| MYL6B | NDUFB11 | 0.702214 | 3 | 0 | 3 |
| MYL6B | NDUFA7 | 0.696709 | 3 | 0 | 3 |
For details and further investigation, click here
