| Full name: telomeric repeat binding factor 1 | Alias Symbol: PIN2|TRF1|TRF | ||
| Type: protein-coding gene | Cytoband: 8q21.11 | ||
| Entrez ID: 7013 | HGNC ID: HGNC:11728 | Ensembl Gene: ENSG00000147601 | OMIM ID: 600951 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TERF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TERF1 | 7013 | 203448_s_at | 0.7818 | 0.3019 | |
| GSE20347 | TERF1 | 7013 | 203448_s_at | 0.7887 | 0.0000 | |
| GSE23400 | TERF1 | 7013 | 203449_s_at | 0.4483 | 0.0000 | |
| GSE26886 | TERF1 | 7013 | 203449_s_at | 0.9559 | 0.0022 | |
| GSE29001 | TERF1 | 7013 | 203448_s_at | 0.5902 | 0.0198 | |
| GSE38129 | TERF1 | 7013 | 203448_s_at | 0.6006 | 0.0004 | |
| GSE45670 | TERF1 | 7013 | 203448_s_at | 0.5246 | 0.0014 | |
| GSE53622 | TERF1 | 7013 | 60332 | 0.4263 | 0.0000 | |
| GSE53624 | TERF1 | 7013 | 60332 | 0.6292 | 0.0000 | |
| GSE63941 | TERF1 | 7013 | 203449_s_at | -0.5542 | 0.1925 | |
| GSE77861 | TERF1 | 7013 | 203448_s_at | 1.2298 | 0.0106 | |
| GSE97050 | TERF1 | 7013 | A_24_P50458 | 0.1450 | 0.7367 | |
| SRP007169 | TERF1 | 7013 | RNAseq | 0.7524 | 0.0546 | |
| SRP008496 | TERF1 | 7013 | RNAseq | 1.1369 | 0.0001 | |
| SRP064894 | TERF1 | 7013 | RNAseq | 0.4161 | 0.0097 | |
| SRP133303 | TERF1 | 7013 | RNAseq | 0.4359 | 0.0023 | |
| SRP159526 | TERF1 | 7013 | RNAseq | 0.6914 | 0.0054 | |
| SRP193095 | TERF1 | 7013 | RNAseq | 0.2855 | 0.0003 | |
| SRP219564 | TERF1 | 7013 | RNAseq | 0.1306 | 0.5473 | |
| TCGA | TERF1 | 7013 | RNAseq | 0.0004 | 0.9944 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TERF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TERF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TERF1 | 7013 | 15 | 0 | 15 | |
| GSE20123 | TERF1 | 7013 | 16 | 0 | 14 | |
| GSE43470 | TERF1 | 7013 | 18 | 1 | 24 | |
| GSE46452 | TERF1 | 7013 | 21 | 1 | 37 | |
| GSE47630 | TERF1 | 7013 | 23 | 0 | 17 | |
| GSE54993 | TERF1 | 7013 | 0 | 19 | 51 | |
| GSE54994 | TERF1 | 7013 | 30 | 0 | 23 | |
| GSE60625 | TERF1 | 7013 | 0 | 4 | 7 | |
| GSE74703 | TERF1 | 7013 | 15 | 1 | 20 | |
| GSE74704 | TERF1 | 7013 | 11 | 0 | 9 | |
| TCGA | TERF1 | 7013 | 50 | 2 | 44 |
Total number of gains: 199; Total number of losses: 28; Total Number of normals: 261.
Somatic mutations of TERF1:
Generating mutation plots.
Highly correlated genes for TERF1:
Showing top 20/1331 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TERF1 | MTERF3 | 0.783313 | 8 | 0 | 8 |
| TERF1 | ZNF451 | 0.769491 | 4 | 0 | 4 |
| TERF1 | FRA10AC1 | 0.765914 | 3 | 0 | 3 |
| TERF1 | RICTOR | 0.756767 | 4 | 0 | 4 |
| TERF1 | SFSWAP | 0.75066 | 4 | 0 | 4 |
| TERF1 | ZNF766 | 0.750092 | 3 | 0 | 3 |
| TERF1 | SLC25A28 | 0.747001 | 3 | 0 | 3 |
| TERF1 | RILPL2 | 0.742333 | 3 | 0 | 3 |
| TERF1 | MYL6B | 0.738143 | 3 | 0 | 3 |
| TERF1 | ZNF550 | 0.724892 | 3 | 0 | 3 |
| TERF1 | ZNF664 | 0.72175 | 3 | 0 | 3 |
| TERF1 | DHX36 | 0.721098 | 7 | 0 | 7 |
| TERF1 | SESTD1 | 0.720932 | 4 | 0 | 3 |
| TERF1 | PKIG | 0.719851 | 3 | 0 | 3 |
| TERF1 | SBNO1 | 0.714358 | 3 | 0 | 3 |
| TERF1 | SNRNP70 | 0.707544 | 4 | 0 | 3 |
| TERF1 | ZNF565 | 0.707364 | 3 | 0 | 3 |
| TERF1 | HAS3 | 0.701127 | 3 | 0 | 3 |
| TERF1 | C8orf82 | 0.69915 | 3 | 0 | 3 |
| TERF1 | WDR35 | 0.697953 | 3 | 0 | 3 |
For details and further investigation, click here
