| Full name: mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase | Alias Symbol: GNT-III | ||
| Type: protein-coding gene | Cytoband: 22q13.1 | ||
| Entrez ID: 4248 | HGNC ID: HGNC:7046 | Ensembl Gene: ENSG00000128268 | OMIM ID: 604621 |
| Drug and gene relationship at DGIdb | |||
Expression of MGAT3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MGAT3 | 4248 | 209764_at | -0.0891 | 0.7154 | |
| GSE20347 | MGAT3 | 4248 | 209764_at | 0.0816 | 0.4140 | |
| GSE23400 | MGAT3 | 4248 | 209764_at | -0.0751 | 0.0112 | |
| GSE26886 | MGAT3 | 4248 | 209764_at | 0.3642 | 0.0039 | |
| GSE29001 | MGAT3 | 4248 | 209764_at | 0.0818 | 0.6573 | |
| GSE38129 | MGAT3 | 4248 | 209764_at | -0.0420 | 0.7049 | |
| GSE45670 | MGAT3 | 4248 | 209764_at | 0.0587 | 0.7079 | |
| GSE53622 | MGAT3 | 4248 | 132830 | -0.4169 | 0.1449 | |
| GSE53624 | MGAT3 | 4248 | 132830 | -0.2802 | 0.2097 | |
| GSE63941 | MGAT3 | 4248 | 209764_at | 0.1604 | 0.4788 | |
| GSE77861 | MGAT3 | 4248 | 244104_at | -0.0964 | 0.4010 | |
| GSE97050 | MGAT3 | 4248 | A_24_P245838 | -0.3931 | 0.4966 | |
| SRP007169 | MGAT3 | 4248 | RNAseq | 0.9165 | 0.2938 | |
| SRP064894 | MGAT3 | 4248 | RNAseq | 0.3312 | 0.2935 | |
| SRP133303 | MGAT3 | 4248 | RNAseq | -0.8506 | 0.0001 | |
| SRP159526 | MGAT3 | 4248 | RNAseq | 1.2762 | 0.0393 | |
| SRP219564 | MGAT3 | 4248 | RNAseq | 0.1716 | 0.7922 | |
| TCGA | MGAT3 | 4248 | RNAseq | -0.9176 | 0.0003 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MGAT3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MGAT3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MGAT3 | 4248 | 6 | 5 | 19 | |
| GSE20123 | MGAT3 | 4248 | 6 | 4 | 20 | |
| GSE43470 | MGAT3 | 4248 | 5 | 6 | 32 | |
| GSE46452 | MGAT3 | 4248 | 32 | 2 | 25 | |
| GSE47630 | MGAT3 | 4248 | 9 | 4 | 27 | |
| GSE54993 | MGAT3 | 4248 | 4 | 5 | 61 | |
| GSE54994 | MGAT3 | 4248 | 10 | 7 | 36 | |
| GSE60625 | MGAT3 | 4248 | 5 | 0 | 6 | |
| GSE74703 | MGAT3 | 4248 | 5 | 4 | 27 | |
| GSE74704 | MGAT3 | 4248 | 3 | 2 | 15 | |
| TCGA | MGAT3 | 4248 | 27 | 15 | 54 |
Total number of gains: 112; Total number of losses: 54; Total Number of normals: 322.
Somatic mutations of MGAT3:
Generating mutation plots.
Highly correlated genes for MGAT3:
Showing top 20/352 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MGAT3 | MYL6B | 0.761363 | 3 | 0 | 3 |
| MGAT3 | ARHGEF6 | 0.721507 | 3 | 0 | 3 |
| MGAT3 | ZNF595 | 0.719944 | 3 | 0 | 3 |
| MGAT3 | MAP3K13 | 0.716086 | 3 | 0 | 3 |
| MGAT3 | PPP2R2D | 0.696875 | 3 | 0 | 3 |
| MGAT3 | C11orf96 | 0.693321 | 3 | 0 | 3 |
| MGAT3 | PDCD6 | 0.693291 | 3 | 0 | 3 |
| MGAT3 | XPNPEP1 | 0.690238 | 3 | 0 | 3 |
| MGAT3 | EFEMP2 | 0.683102 | 3 | 0 | 3 |
| MGAT3 | FAM50A | 0.682837 | 3 | 0 | 3 |
| MGAT3 | PLA2G2A | 0.681246 | 3 | 0 | 3 |
| MGAT3 | NKAPL | 0.679476 | 3 | 0 | 3 |
| MGAT3 | FKBP10 | 0.674387 | 4 | 0 | 4 |
| MGAT3 | FAR2 | 0.668055 | 3 | 0 | 3 |
| MGAT3 | NOA1 | 0.665836 | 4 | 0 | 4 |
| MGAT3 | ZRANB2 | 0.66569 | 3 | 0 | 3 |
| MGAT3 | SULT1C2 | 0.662624 | 3 | 0 | 3 |
| MGAT3 | COL14A1 | 0.660188 | 3 | 0 | 3 |
| MGAT3 | LRP5L | 0.658842 | 4 | 0 | 3 |
| MGAT3 | USP9Y | 0.658482 | 4 | 0 | 4 |
For details and further investigation, click here
