| Full name: NLR family pyrin domain containing 4 | Alias Symbol: PYPAF4|FLJ32126|PAN2|RNH2|CLR19.5|CT58 | ||
| Type: protein-coding gene | Cytoband: 19q13.43 | ||
| Entrez ID: 147945 | HGNC ID: HGNC:22943 | Ensembl Gene: ENSG00000160505 | OMIM ID: 609645 |
| Drug and gene relationship at DGIdb | |||
Expression of NLRP4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NLRP4 | 147945 | 242334_at | 0.0018 | 0.9966 | |
| GSE26886 | NLRP4 | 147945 | 242334_at | 0.0182 | 0.8895 | |
| GSE45670 | NLRP4 | 147945 | 242334_at | 0.1014 | 0.2267 | |
| GSE53622 | NLRP4 | 147945 | 84671 | -0.1564 | 0.4302 | |
| GSE53624 | NLRP4 | 147945 | 16296 | -0.2357 | 0.0223 | |
| GSE63941 | NLRP4 | 147945 | 242334_at | 0.1530 | 0.2269 | |
| GSE77861 | NLRP4 | 147945 | 242334_at | -0.1010 | 0.3076 | |
| GSE97050 | NLRP4 | 147945 | A_33_P3406047 | -0.0137 | 0.9635 | |
| TCGA | NLRP4 | 147945 | RNAseq | 1.2366 | 0.3045 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NLRP4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NLRP4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NLRP4 | 147945 | 3 | 4 | 23 | |
| GSE20123 | NLRP4 | 147945 | 3 | 3 | 24 | |
| GSE43470 | NLRP4 | 147945 | 3 | 9 | 31 | |
| GSE46452 | NLRP4 | 147945 | 45 | 1 | 13 | |
| GSE47630 | NLRP4 | 147945 | 8 | 6 | 26 | |
| GSE54993 | NLRP4 | 147945 | 17 | 4 | 49 | |
| GSE54994 | NLRP4 | 147945 | 5 | 13 | 35 | |
| GSE60625 | NLRP4 | 147945 | 9 | 0 | 2 | |
| GSE74703 | NLRP4 | 147945 | 3 | 6 | 27 | |
| GSE74704 | NLRP4 | 147945 | 3 | 1 | 16 | |
| TCGA | NLRP4 | 147945 | 19 | 16 | 61 |
Total number of gains: 118; Total number of losses: 63; Total Number of normals: 307.
Somatic mutations of NLRP4:
Generating mutation plots.
Highly correlated genes for NLRP4:
Showing top 20/33 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NLRP4 | TEKT1 | 0.714822 | 3 | 0 | 3 |
| NLRP4 | DNAJC5G | 0.702894 | 3 | 0 | 3 |
| NLRP4 | KRTAP11-1 | 0.684033 | 3 | 0 | 3 |
| NLRP4 | TMPRSS6 | 0.662805 | 3 | 0 | 3 |
| NLRP4 | TAS2R9 | 0.66148 | 3 | 0 | 3 |
| NLRP4 | FNDC9 | 0.650264 | 3 | 0 | 3 |
| NLRP4 | SLC35F3 | 0.645047 | 3 | 0 | 3 |
| NLRP4 | TBXAS1 | 0.635879 | 3 | 0 | 3 |
| NLRP4 | CAPSL | 0.634594 | 3 | 0 | 3 |
| NLRP4 | TMEM235 | 0.630401 | 3 | 0 | 3 |
| NLRP4 | SPP2 | 0.624981 | 3 | 0 | 3 |
| NLRP4 | WFDC12 | 0.61544 | 3 | 0 | 3 |
| NLRP4 | MFSD6L | 0.610358 | 4 | 0 | 3 |
| NLRP4 | KLK14 | 0.609389 | 3 | 0 | 3 |
| NLRP4 | SIT1 | 0.592296 | 3 | 0 | 3 |
| NLRP4 | ABCG4 | 0.589185 | 4 | 0 | 3 |
| NLRP4 | TTLL2 | 0.586525 | 3 | 0 | 3 |
| NLRP4 | LGALS13 | 0.585266 | 3 | 0 | 3 |
| NLRP4 | BPIFC | 0.582065 | 4 | 0 | 3 |
| NLRP4 | LINC00221 | 0.578524 | 3 | 0 | 3 |
For details and further investigation, click here
