| Full name: signaling threshold regulating transmembrane adaptor 1 | Alias Symbol: SIT | ||
| Type: protein-coding gene | Cytoband: 9p13.3 | ||
| Entrez ID: 27240 | HGNC ID: HGNC:17710 | Ensembl Gene: ENSG00000137078 | OMIM ID: 604964 |
| Drug and gene relationship at DGIdb | |||
Expression of SIT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIT1 | 27240 | 205484_at | -0.2160 | 0.6992 | |
| GSE20347 | SIT1 | 27240 | 205484_at | -0.0796 | 0.3794 | |
| GSE23400 | SIT1 | 27240 | 205484_at | -0.2602 | 0.0000 | |
| GSE26886 | SIT1 | 27240 | 205484_at | -0.1263 | 0.5303 | |
| GSE29001 | SIT1 | 27240 | 205484_at | -0.2107 | 0.1436 | |
| GSE38129 | SIT1 | 27240 | 205484_at | -0.2680 | 0.0136 | |
| GSE45670 | SIT1 | 27240 | 205484_at | -0.1538 | 0.3016 | |
| GSE53622 | SIT1 | 27240 | 126865 | -0.0815 | 0.4892 | |
| GSE53624 | SIT1 | 27240 | 126865 | -1.2202 | 0.0000 | |
| GSE63941 | SIT1 | 27240 | 205484_at | 0.3130 | 0.0850 | |
| GSE77861 | SIT1 | 27240 | 205484_at | -0.1785 | 0.1984 | |
| GSE97050 | SIT1 | 27240 | A_23_P43369 | 1.4871 | 0.1819 | |
| SRP133303 | SIT1 | 27240 | RNAseq | -0.9322 | 0.0354 | |
| SRP219564 | SIT1 | 27240 | RNAseq | 0.3621 | 0.5411 | |
| TCGA | SIT1 | 27240 | RNAseq | 0.1962 | 0.5703 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SIT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIT1 | 27240 | 3 | 12 | 15 | |
| GSE20123 | SIT1 | 27240 | 3 | 12 | 15 | |
| GSE43470 | SIT1 | 27240 | 3 | 10 | 30 | |
| GSE46452 | SIT1 | 27240 | 6 | 15 | 38 | |
| GSE47630 | SIT1 | 27240 | 1 | 20 | 19 | |
| GSE54993 | SIT1 | 27240 | 6 | 0 | 64 | |
| GSE54994 | SIT1 | 27240 | 6 | 12 | 35 | |
| GSE60625 | SIT1 | 27240 | 0 | 0 | 11 | |
| GSE74703 | SIT1 | 27240 | 2 | 7 | 27 | |
| GSE74704 | SIT1 | 27240 | 0 | 10 | 10 | |
| TCGA | SIT1 | 27240 | 17 | 44 | 35 |
Total number of gains: 47; Total number of losses: 142; Total Number of normals: 299.
Somatic mutations of SIT1:
Generating mutation plots.
Highly correlated genes for SIT1:
Showing top 20/693 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIT1 | SLAMF6 | 0.754231 | 4 | 0 | 4 |
| SIT1 | COL23A1 | 0.734818 | 3 | 0 | 3 |
| SIT1 | SPOCK2 | 0.727845 | 6 | 0 | 5 |
| SIT1 | C3orf80 | 0.720985 | 3 | 0 | 3 |
| SIT1 | HAND1 | 0.717319 | 3 | 0 | 3 |
| SIT1 | EXOC3L2 | 0.712 | 3 | 0 | 3 |
| SIT1 | SERPIND1 | 0.710864 | 3 | 0 | 3 |
| SIT1 | GAPT | 0.70933 | 3 | 0 | 3 |
| SIT1 | RHOH | 0.707536 | 7 | 0 | 7 |
| SIT1 | SLCO2A1 | 0.707465 | 3 | 0 | 3 |
| SIT1 | IRS4 | 0.705305 | 3 | 0 | 3 |
| SIT1 | CD79B | 0.704746 | 7 | 0 | 6 |
| SIT1 | PVRIG | 0.70395 | 8 | 0 | 7 |
| SIT1 | MYL3 | 0.691845 | 3 | 0 | 3 |
| SIT1 | FLI1 | 0.686265 | 4 | 0 | 3 |
| SIT1 | IRF8 | 0.685143 | 5 | 0 | 4 |
| SIT1 | SNX29 | 0.684351 | 3 | 0 | 3 |
| SIT1 | MYCN | 0.68425 | 3 | 0 | 3 |
| SIT1 | KCNN1 | 0.681641 | 4 | 0 | 4 |
| SIT1 | IKZF3 | 0.678063 | 6 | 0 | 5 |
For details and further investigation, click here
