| Full name: transmembrane serine protease 6 | Alias Symbol: FLJ30744 | ||
| Type: protein-coding gene | Cytoband: 22q12.3 | ||
| Entrez ID: 164656 | HGNC ID: HGNC:16517 | Ensembl Gene: ENSG00000187045 | OMIM ID: 609862 |
| Drug and gene relationship at DGIdb | |||
Expression of TMPRSS6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMPRSS6 | 164656 | 214955_at | -0.1208 | 0.5670 | |
| GSE20347 | TMPRSS6 | 164656 | 214955_at | -0.1791 | 0.0244 | |
| GSE23400 | TMPRSS6 | 164656 | 214955_at | -0.1342 | 0.0006 | |
| GSE26886 | TMPRSS6 | 164656 | 214955_at | 0.1245 | 0.4878 | |
| GSE29001 | TMPRSS6 | 164656 | 214955_at | -0.2193 | 0.1851 | |
| GSE38129 | TMPRSS6 | 164656 | 214955_at | -0.0961 | 0.3899 | |
| GSE45670 | TMPRSS6 | 164656 | 214955_at | 0.0959 | 0.4223 | |
| GSE53622 | TMPRSS6 | 164656 | 21551 | 0.5089 | 0.0000 | |
| GSE53624 | TMPRSS6 | 164656 | 21551 | 0.8117 | 0.0000 | |
| GSE63941 | TMPRSS6 | 164656 | 214955_at | 0.4221 | 0.0731 | |
| GSE77861 | TMPRSS6 | 164656 | 214955_at | -0.1381 | 0.3601 | |
| GSE97050 | TMPRSS6 | 164656 | A_23_P211493 | 0.1580 | 0.6167 | |
| SRP159526 | TMPRSS6 | 164656 | RNAseq | 1.4600 | 0.0771 | |
| SRP219564 | TMPRSS6 | 164656 | RNAseq | 1.3455 | 0.0153 | |
| TCGA | TMPRSS6 | 164656 | RNAseq | -1.0189 | 0.0014 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by TMPRSS6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMPRSS6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMPRSS6 | 164656 | 6 | 6 | 18 | |
| GSE20123 | TMPRSS6 | 164656 | 6 | 5 | 19 | |
| GSE43470 | TMPRSS6 | 164656 | 4 | 6 | 33 | |
| GSE46452 | TMPRSS6 | 164656 | 31 | 1 | 27 | |
| GSE47630 | TMPRSS6 | 164656 | 8 | 5 | 27 | |
| GSE54993 | TMPRSS6 | 164656 | 3 | 6 | 61 | |
| GSE54994 | TMPRSS6 | 164656 | 10 | 8 | 35 | |
| GSE60625 | TMPRSS6 | 164656 | 5 | 0 | 6 | |
| GSE74703 | TMPRSS6 | 164656 | 4 | 4 | 28 | |
| GSE74704 | TMPRSS6 | 164656 | 3 | 2 | 15 | |
| TCGA | TMPRSS6 | 164656 | 27 | 16 | 53 |
Total number of gains: 107; Total number of losses: 59; Total Number of normals: 322.
Somatic mutations of TMPRSS6:
Generating mutation plots.
Highly correlated genes for TMPRSS6:
Showing top 20/825 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMPRSS6 | TNFRSF13C | 0.713673 | 4 | 0 | 4 |
| TMPRSS6 | LINC00167 | 0.712759 | 4 | 0 | 4 |
| TMPRSS6 | CAMK2B | 0.689044 | 8 | 0 | 7 |
| TMPRSS6 | LINC01119 | 0.685934 | 3 | 0 | 3 |
| TMPRSS6 | CLYBL-AS2 | 0.68133 | 3 | 0 | 3 |
| TMPRSS6 | CLPS | 0.669673 | 8 | 0 | 7 |
| TMPRSS6 | NR5A1 | 0.665719 | 3 | 0 | 3 |
| TMPRSS6 | TNFRSF13B | 0.665715 | 3 | 0 | 3 |
| TMPRSS6 | HRH2 | 0.663913 | 7 | 0 | 5 |
| TMPRSS6 | NLRP4 | 0.662805 | 3 | 0 | 3 |
| TMPRSS6 | P2RX6 | 0.661505 | 6 | 0 | 5 |
| TMPRSS6 | SPATA32 | 0.66043 | 4 | 0 | 3 |
| TMPRSS6 | RHAG | 0.658932 | 3 | 0 | 3 |
| TMPRSS6 | OR2H2 | 0.6583 | 7 | 0 | 6 |
| TMPRSS6 | NOS2 | 0.655587 | 3 | 0 | 3 |
| TMPRSS6 | KRT76 | 0.650707 | 4 | 0 | 4 |
| TMPRSS6 | ATP1A3 | 0.650647 | 4 | 0 | 3 |
| TMPRSS6 | ALOX15 | 0.649242 | 3 | 0 | 3 |
| TMPRSS6 | NOX5 | 0.648597 | 5 | 0 | 5 |
| TMPRSS6 | TTPA | 0.648362 | 3 | 0 | 3 |
For details and further investigation, click here
