| Full name: thromboxane A synthase 1 | Alias Symbol: CYP5|CYP5A1|THAS|TXS|TXAS|TS | ||
| Type: protein-coding gene | Cytoband: 7q34 | ||
| Entrez ID: 6916 | HGNC ID: HGNC:11609 | Ensembl Gene: ENSG00000059377 | OMIM ID: 274180 |
| Drug and gene relationship at DGIdb | |||
TBXAS1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04611 | Platelet activation |
Expression of TBXAS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TBXAS1 | 6916 | 208130_s_at | 0.0733 | 0.9254 | |
| GSE20347 | TBXAS1 | 6916 | 208130_s_at | -0.1775 | 0.0129 | |
| GSE23400 | TBXAS1 | 6916 | 208130_s_at | -0.1032 | 0.0362 | |
| GSE26886 | TBXAS1 | 6916 | 208130_s_at | 0.0988 | 0.5602 | |
| GSE29001 | TBXAS1 | 6916 | 208130_s_at | -0.1349 | 0.3671 | |
| GSE38129 | TBXAS1 | 6916 | 208130_s_at | -0.1531 | 0.1726 | |
| GSE45670 | TBXAS1 | 6916 | 208130_s_at | -0.0576 | 0.6664 | |
| GSE53622 | TBXAS1 | 6916 | 62976 | 0.0480 | 0.7074 | |
| GSE53624 | TBXAS1 | 6916 | 62976 | 0.0853 | 0.5832 | |
| GSE63941 | TBXAS1 | 6916 | 208130_s_at | -0.6033 | 0.0219 | |
| GSE77861 | TBXAS1 | 6916 | 208130_s_at | -0.0848 | 0.5539 | |
| GSE97050 | TBXAS1 | 6916 | A_24_P274814 | 0.5297 | 0.1997 | |
| SRP007169 | TBXAS1 | 6916 | RNAseq | -1.6348 | 0.0431 | |
| SRP064894 | TBXAS1 | 6916 | RNAseq | -0.0666 | 0.7877 | |
| SRP133303 | TBXAS1 | 6916 | RNAseq | -0.3641 | 0.0077 | |
| SRP159526 | TBXAS1 | 6916 | RNAseq | -0.8435 | 0.1017 | |
| SRP193095 | TBXAS1 | 6916 | RNAseq | -0.4997 | 0.0005 | |
| SRP219564 | TBXAS1 | 6916 | RNAseq | -0.6620 | 0.1862 | |
| TCGA | TBXAS1 | 6916 | RNAseq | -0.1131 | 0.4779 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by TBXAS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TBXAS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TBXAS1 | 6916 | 5 | 2 | 23 | |
| GSE20123 | TBXAS1 | 6916 | 5 | 2 | 23 | |
| GSE43470 | TBXAS1 | 6916 | 2 | 4 | 37 | |
| GSE46452 | TBXAS1 | 6916 | 7 | 2 | 50 | |
| GSE47630 | TBXAS1 | 6916 | 7 | 4 | 29 | |
| GSE54993 | TBXAS1 | 6916 | 3 | 5 | 62 | |
| GSE54994 | TBXAS1 | 6916 | 5 | 8 | 40 | |
| GSE60625 | TBXAS1 | 6916 | 0 | 0 | 11 | |
| GSE74703 | TBXAS1 | 6916 | 2 | 4 | 30 | |
| GSE74704 | TBXAS1 | 6916 | 1 | 2 | 17 | |
| TCGA | TBXAS1 | 6916 | 28 | 24 | 44 |
Total number of gains: 65; Total number of losses: 57; Total Number of normals: 366.
Somatic mutations of TBXAS1:
Generating mutation plots.
Highly correlated genes for TBXAS1:
Showing top 20/289 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TBXAS1 | MPEG1 | 0.775129 | 4 | 0 | 4 |
| TBXAS1 | MEI1 | 0.734647 | 4 | 0 | 4 |
| TBXAS1 | CYB5R4 | 0.722947 | 3 | 0 | 3 |
| TBXAS1 | MZB1 | 0.721145 | 5 | 0 | 5 |
| TBXAS1 | CCDC88B | 0.712536 | 3 | 0 | 3 |
| TBXAS1 | IGFLR1 | 0.708892 | 5 | 0 | 5 |
| TBXAS1 | LAPTM5 | 0.698538 | 6 | 0 | 5 |
| TBXAS1 | SIGLEC10 | 0.695835 | 6 | 0 | 5 |
| TBXAS1 | PIK3AP1 | 0.694651 | 4 | 0 | 4 |
| TBXAS1 | HLA-DQA1 | 0.691437 | 4 | 0 | 4 |
| TBXAS1 | ITGAM | 0.688076 | 5 | 0 | 4 |
| TBXAS1 | GPR34 | 0.68227 | 5 | 0 | 4 |
| TBXAS1 | CLEC12A | 0.674177 | 3 | 0 | 3 |
| TBXAS1 | TYROBP | 0.67312 | 6 | 0 | 5 |
| TBXAS1 | GAPT | 0.672022 | 3 | 0 | 3 |
| TBXAS1 | GPSM3 | 0.671875 | 5 | 0 | 5 |
| TBXAS1 | FMNL1 | 0.663631 | 6 | 0 | 4 |
| TBXAS1 | C1QB | 0.662718 | 6 | 0 | 5 |
| TBXAS1 | LILRA6 | 0.662533 | 5 | 0 | 4 |
| TBXAS1 | PIK3CG | 0.66068 | 8 | 0 | 6 |
For details and further investigation, click here
