| Full name: secreted phosphoprotein 2 | Alias Symbol: SPP24 | ||
| Type: protein-coding gene | Cytoband: 2q37.1 | ||
| Entrez ID: 6694 | HGNC ID: HGNC:11256 | Ensembl Gene: ENSG00000072080 | OMIM ID: 602637 |
| Drug and gene relationship at DGIdb | |||
Expression of SPP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPP2 | 6694 | 214478_at | 0.0309 | 0.9325 | |
| GSE20347 | SPP2 | 6694 | 214478_at | 0.0700 | 0.3418 | |
| GSE23400 | SPP2 | 6694 | 214478_at | -0.1015 | 0.0287 | |
| GSE26886 | SPP2 | 6694 | 214478_at | 0.0212 | 0.8880 | |
| GSE29001 | SPP2 | 6694 | 214478_at | -0.2108 | 0.0621 | |
| GSE38129 | SPP2 | 6694 | 214478_at | -0.0584 | 0.6821 | |
| GSE45670 | SPP2 | 6694 | 214478_at | -0.0027 | 0.9846 | |
| GSE53622 | SPP2 | 6694 | 76798 | 0.3720 | 0.0521 | |
| GSE53624 | SPP2 | 6694 | 76798 | 0.7286 | 0.0000 | |
| GSE63941 | SPP2 | 6694 | 214478_at | -0.0820 | 0.6099 | |
| GSE77861 | SPP2 | 6694 | 214478_at | -0.1605 | 0.0595 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SPP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPP2 | 6694 | 1 | 11 | 18 | |
| GSE20123 | SPP2 | 6694 | 1 | 11 | 18 | |
| GSE43470 | SPP2 | 6694 | 1 | 9 | 33 | |
| GSE46452 | SPP2 | 6694 | 0 | 5 | 54 | |
| GSE47630 | SPP2 | 6694 | 4 | 5 | 31 | |
| GSE54993 | SPP2 | 6694 | 3 | 2 | 65 | |
| GSE54994 | SPP2 | 6694 | 6 | 10 | 37 | |
| GSE60625 | SPP2 | 6694 | 0 | 3 | 8 | |
| GSE74703 | SPP2 | 6694 | 1 | 7 | 28 | |
| GSE74704 | SPP2 | 6694 | 1 | 5 | 14 | |
| TCGA | SPP2 | 6694 | 11 | 29 | 56 |
Total number of gains: 29; Total number of losses: 97; Total Number of normals: 362.
Somatic mutations of SPP2:
Generating mutation plots.
Highly correlated genes for SPP2:
Showing top 20/445 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPP2 | ZKSCAN3 | 0.698088 | 3 | 0 | 3 |
| SPP2 | FOXN3-AS2 | 0.668919 | 3 | 0 | 3 |
| SPP2 | ABCC12 | 0.665657 | 3 | 0 | 3 |
| SPP2 | TRPV5 | 0.660239 | 3 | 0 | 3 |
| SPP2 | KIR3DL3 | 0.652981 | 4 | 0 | 3 |
| SPP2 | EPOR | 0.652859 | 5 | 0 | 5 |
| SPP2 | THRB | 0.651923 | 3 | 0 | 3 |
| SPP2 | KIR2DS4 | 0.650674 | 3 | 0 | 3 |
| SPP2 | ADCYAP1R1 | 0.640108 | 4 | 0 | 4 |
| SPP2 | NOS1 | 0.639737 | 5 | 0 | 5 |
| SPP2 | TTPA | 0.639585 | 3 | 0 | 3 |
| SPP2 | CELA1 | 0.638414 | 3 | 0 | 3 |
| SPP2 | KIR2DL2 | 0.633781 | 5 | 0 | 4 |
| SPP2 | GPRC5D | 0.629244 | 3 | 0 | 3 |
| SPP2 | TAS2R9 | 0.627634 | 4 | 0 | 4 |
| SPP2 | ALDOB | 0.627487 | 4 | 0 | 4 |
| SPP2 | BTN1A1 | 0.626174 | 5 | 0 | 4 |
| SPP2 | DCC | 0.62556 | 3 | 0 | 3 |
| SPP2 | TVP23A | 0.625198 | 3 | 0 | 3 |
| SPP2 | NLRP4 | 0.624981 | 3 | 0 | 3 |
For details and further investigation, click here
