| Full name: polynucleotide kinase 3'-phosphatase | Alias Symbol: PNK | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 11284 | HGNC ID: HGNC:9154 | Ensembl Gene: ENSG00000039650 | OMIM ID: 605610 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PNKP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PNKP | 11284 | 218961_s_at | 0.3434 | 0.4157 | |
| GSE20347 | PNKP | 11284 | 218961_s_at | -0.0487 | 0.8048 | |
| GSE23400 | PNKP | 11284 | 218961_s_at | 0.1048 | 0.1411 | |
| GSE26886 | PNKP | 11284 | 218961_s_at | 0.4276 | 0.0412 | |
| GSE29001 | PNKP | 11284 | 218961_s_at | -0.0985 | 0.7710 | |
| GSE38129 | PNKP | 11284 | 218961_s_at | 0.2521 | 0.0532 | |
| GSE45670 | PNKP | 11284 | 218961_s_at | 0.1298 | 0.4617 | |
| GSE53622 | PNKP | 11284 | 72114 | 0.1368 | 0.1296 | |
| GSE53624 | PNKP | 11284 | 72114 | 0.3508 | 0.0000 | |
| GSE63941 | PNKP | 11284 | 218961_s_at | 0.3644 | 0.5410 | |
| GSE77861 | PNKP | 11284 | 218961_s_at | 0.0766 | 0.7575 | |
| GSE97050 | PNKP | 11284 | A_33_P3402918 | 0.2694 | 0.3039 | |
| SRP007169 | PNKP | 11284 | RNAseq | 1.1360 | 0.0813 | |
| SRP064894 | PNKP | 11284 | RNAseq | 0.6997 | 0.0009 | |
| SRP133303 | PNKP | 11284 | RNAseq | 0.1022 | 0.6174 | |
| SRP159526 | PNKP | 11284 | RNAseq | 0.6654 | 0.0871 | |
| SRP193095 | PNKP | 11284 | RNAseq | 0.5424 | 0.0015 | |
| SRP219564 | PNKP | 11284 | RNAseq | 0.2797 | 0.2849 | |
| TCGA | PNKP | 11284 | RNAseq | 0.0489 | 0.3812 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PNKP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PNKP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PNKP | 11284 | 4 | 4 | 22 | |
| GSE20123 | PNKP | 11284 | 4 | 3 | 23 | |
| GSE43470 | PNKP | 11284 | 5 | 11 | 27 | |
| GSE46452 | PNKP | 11284 | 45 | 1 | 13 | |
| GSE47630 | PNKP | 11284 | 10 | 6 | 24 | |
| GSE54993 | PNKP | 11284 | 17 | 4 | 49 | |
| GSE54994 | PNKP | 11284 | 4 | 14 | 35 | |
| GSE60625 | PNKP | 11284 | 9 | 0 | 2 | |
| GSE74703 | PNKP | 11284 | 5 | 7 | 24 | |
| GSE74704 | PNKP | 11284 | 4 | 1 | 15 | |
| TCGA | PNKP | 11284 | 14 | 18 | 64 |
Total number of gains: 121; Total number of losses: 69; Total Number of normals: 298.
Somatic mutations of PNKP:
Generating mutation plots.
Highly correlated genes for PNKP:
Showing top 20/492 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PNKP | PPP1R37 | 0.800034 | 4 | 0 | 4 |
| PNKP | GGA3 | 0.79741 | 3 | 0 | 3 |
| PNKP | SLC33A1 | 0.7852 | 3 | 0 | 3 |
| PNKP | FOXP4 | 0.783632 | 3 | 0 | 3 |
| PNKP | DCTN1 | 0.768346 | 3 | 0 | 3 |
| PNKP | WTIP | 0.766146 | 3 | 0 | 3 |
| PNKP | POLR1C | 0.754327 | 3 | 0 | 3 |
| PNKP | THBS4 | 0.740157 | 3 | 0 | 3 |
| PNKP | ZNF691 | 0.728647 | 3 | 0 | 3 |
| PNKP | TBPL1 | 0.72817 | 3 | 0 | 3 |
| PNKP | XXYLT1 | 0.727731 | 4 | 0 | 4 |
| PNKP | ARMC6 | 0.727501 | 4 | 0 | 4 |
| PNKP | GTDC1 | 0.726832 | 3 | 0 | 3 |
| PNKP | EVI5L | 0.721818 | 3 | 0 | 3 |
| PNKP | MLLT1 | 0.717369 | 4 | 0 | 3 |
| PNKP | ARPC4 | 0.716706 | 3 | 0 | 3 |
| PNKP | CYHR1 | 0.715339 | 4 | 0 | 3 |
| PNKP | ZNF830 | 0.71494 | 3 | 0 | 3 |
| PNKP | GLB1L2 | 0.713189 | 3 | 0 | 3 |
| PNKP | SLC25A29 | 0.71264 | 3 | 0 | 3 |
For details and further investigation, click here
