| Full name: thrombospondin 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q14.1 | ||
| Entrez ID: 7060 | HGNC ID: HGNC:11788 | Ensembl Gene: ENSG00000113296 | OMIM ID: 600715 |
| Drug and gene relationship at DGIdb | |||
THBS4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion |
Expression of THBS4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | THBS4 | 7060 | 204776_at | -0.2058 | 0.8971 | |
| GSE20347 | THBS4 | 7060 | 204776_at | 0.0996 | 0.4491 | |
| GSE23400 | THBS4 | 7060 | 204776_at | -0.0865 | 0.5482 | |
| GSE26886 | THBS4 | 7060 | 204776_at | 1.3270 | 0.0015 | |
| GSE29001 | THBS4 | 7060 | 204776_at | 0.1484 | 0.7006 | |
| GSE38129 | THBS4 | 7060 | 204776_at | -0.3085 | 0.4871 | |
| GSE45670 | THBS4 | 7060 | 204776_at | -0.7316 | 0.0034 | |
| GSE53622 | THBS4 | 7060 | 76213 | 0.8407 | 0.0179 | |
| GSE53624 | THBS4 | 7060 | 76213 | 1.1141 | 0.0000 | |
| GSE63941 | THBS4 | 7060 | 204776_at | -0.3833 | 0.2039 | |
| GSE77861 | THBS4 | 7060 | 204776_at | -0.0810 | 0.5066 | |
| GSE97050 | THBS4 | 7060 | A_24_P260443 | 0.6129 | 0.2110 | |
| SRP007169 | THBS4 | 7060 | RNAseq | 3.4151 | 0.0006 | |
| SRP064894 | THBS4 | 7060 | RNAseq | 2.3100 | 0.0000 | |
| SRP133303 | THBS4 | 7060 | RNAseq | -0.2342 | 0.5006 | |
| SRP159526 | THBS4 | 7060 | RNAseq | 1.4547 | 0.0565 | |
| SRP219564 | THBS4 | 7060 | RNAseq | 0.7457 | 0.6251 | |
| TCGA | THBS4 | 7060 | RNAseq | -0.3977 | 0.2892 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by THBS4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of THBS4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | THBS4 | 7060 | 1 | 13 | 16 | |
| GSE20123 | THBS4 | 7060 | 1 | 13 | 16 | |
| GSE43470 | THBS4 | 7060 | 1 | 11 | 31 | |
| GSE46452 | THBS4 | 7060 | 0 | 28 | 31 | |
| GSE47630 | THBS4 | 7060 | 1 | 19 | 20 | |
| GSE54993 | THBS4 | 7060 | 8 | 1 | 61 | |
| GSE54994 | THBS4 | 7060 | 2 | 18 | 33 | |
| GSE60625 | THBS4 | 7060 | 0 | 0 | 11 | |
| GSE74703 | THBS4 | 7060 | 1 | 7 | 28 | |
| GSE74704 | THBS4 | 7060 | 1 | 6 | 13 | |
| TCGA | THBS4 | 7060 | 5 | 49 | 42 |
Total number of gains: 21; Total number of losses: 165; Total Number of normals: 302.
Somatic mutations of THBS4:
Generating mutation plots.
Highly correlated genes for THBS4:
Showing top 20/817 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| THBS4 | PNKP | 0.740157 | 3 | 0 | 3 |
| THBS4 | ZNF653 | 0.73595 | 3 | 0 | 3 |
| THBS4 | TSNARE1 | 0.711629 | 4 | 0 | 4 |
| THBS4 | B9D2 | 0.709716 | 4 | 0 | 3 |
| THBS4 | MED12 | 0.706707 | 3 | 0 | 3 |
| THBS4 | VAMP3 | 0.704955 | 3 | 0 | 3 |
| THBS4 | TEAD2 | 0.698516 | 4 | 0 | 3 |
| THBS4 | CCDC159 | 0.697386 | 3 | 0 | 3 |
| THBS4 | CCDC97 | 0.696249 | 3 | 0 | 3 |
| THBS4 | TRIM8 | 0.693795 | 5 | 0 | 5 |
| THBS4 | WDR25 | 0.692125 | 5 | 0 | 5 |
| THBS4 | AFF1 | 0.692031 | 3 | 0 | 3 |
| THBS4 | PMPCB | 0.690998 | 3 | 0 | 3 |
| THBS4 | MTCH1 | 0.690204 | 3 | 0 | 3 |
| THBS4 | CPLX1 | 0.688834 | 3 | 0 | 3 |
| THBS4 | CCNY | 0.688656 | 3 | 0 | 3 |
| THBS4 | TMEM205 | 0.688422 | 3 | 0 | 3 |
| THBS4 | DLEU7 | 0.688154 | 3 | 0 | 3 |
| THBS4 | GOLPH3 | 0.686724 | 3 | 0 | 3 |
| THBS4 | ECSIT | 0.686569 | 3 | 0 | 3 |
For details and further investigation, click here
