| Full name: dynactin subunit 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p13.1 | ||
| Entrez ID: 1639 | HGNC ID: HGNC:2711 | Ensembl Gene: ENSG00000204843 | OMIM ID: 601143 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DCTN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DCTN1 | 1639 | 211780_x_at | 0.1795 | 0.5947 | |
| GSE20347 | DCTN1 | 1639 | 211780_x_at | -0.0679 | 0.5293 | |
| GSE23400 | DCTN1 | 1639 | 211780_x_at | -0.0086 | 0.8635 | |
| GSE26886 | DCTN1 | 1639 | 211780_x_at | -0.0355 | 0.8749 | |
| GSE29001 | DCTN1 | 1639 | 211780_x_at | -0.1886 | 0.5555 | |
| GSE38129 | DCTN1 | 1639 | 211780_x_at | -0.1041 | 0.2298 | |
| GSE45670 | DCTN1 | 1639 | 211780_x_at | 0.1283 | 0.1715 | |
| GSE53622 | DCTN1 | 1639 | 14089 | -0.0706 | 0.2992 | |
| GSE53624 | DCTN1 | 1639 | 14089 | 0.0114 | 0.8765 | |
| GSE63941 | DCTN1 | 1639 | 211780_x_at | -0.0102 | 0.9776 | |
| GSE77861 | DCTN1 | 1639 | 211780_x_at | 0.1732 | 0.4634 | |
| GSE97050 | DCTN1 | 1639 | A_33_P3264577 | 0.3215 | 0.2462 | |
| SRP007169 | DCTN1 | 1639 | RNAseq | 1.4213 | 0.0082 | |
| SRP008496 | DCTN1 | 1639 | RNAseq | 1.1842 | 0.0010 | |
| SRP064894 | DCTN1 | 1639 | RNAseq | 0.3612 | 0.0112 | |
| SRP133303 | DCTN1 | 1639 | RNAseq | 0.1595 | 0.3091 | |
| SRP159526 | DCTN1 | 1639 | RNAseq | 0.2883 | 0.2580 | |
| SRP193095 | DCTN1 | 1639 | RNAseq | 0.1036 | 0.3561 | |
| SRP219564 | DCTN1 | 1639 | RNAseq | -0.0029 | 0.9920 | |
| TCGA | DCTN1 | 1639 | RNAseq | -0.0181 | 0.6466 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by DCTN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DCTN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DCTN1 | 1639 | 10 | 1 | 19 | |
| GSE20123 | DCTN1 | 1639 | 11 | 1 | 18 | |
| GSE43470 | DCTN1 | 1639 | 4 | 0 | 39 | |
| GSE46452 | DCTN1 | 1639 | 2 | 3 | 54 | |
| GSE47630 | DCTN1 | 1639 | 7 | 0 | 33 | |
| GSE54993 | DCTN1 | 1639 | 0 | 6 | 64 | |
| GSE54994 | DCTN1 | 1639 | 10 | 0 | 43 | |
| GSE60625 | DCTN1 | 1639 | 0 | 3 | 8 | |
| GSE74703 | DCTN1 | 1639 | 4 | 0 | 32 | |
| GSE74704 | DCTN1 | 1639 | 8 | 0 | 12 | |
| TCGA | DCTN1 | 1639 | 37 | 2 | 57 |
Total number of gains: 93; Total number of losses: 16; Total Number of normals: 379.
Somatic mutations of DCTN1:
Generating mutation plots.
Highly correlated genes for DCTN1:
Showing top 20/379 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DCTN1 | ZNF408 | 0.887791 | 3 | 0 | 3 |
| DCTN1 | FN3K | 0.770073 | 3 | 0 | 3 |
| DCTN1 | PNKP | 0.768346 | 3 | 0 | 3 |
| DCTN1 | CDK9 | 0.75699 | 3 | 0 | 3 |
| DCTN1 | C19orf47 | 0.740791 | 3 | 0 | 3 |
| DCTN1 | GSK3A | 0.738609 | 4 | 0 | 4 |
| DCTN1 | TNP2 | 0.736655 | 3 | 0 | 3 |
| DCTN1 | C3orf33 | 0.736416 | 3 | 0 | 3 |
| DCTN1 | TBCD | 0.72953 | 4 | 0 | 4 |
| DCTN1 | MAPRE3 | 0.728513 | 4 | 0 | 4 |
| DCTN1 | ITGB1BP1 | 0.728269 | 3 | 0 | 3 |
| DCTN1 | IRF2BP1 | 0.727425 | 4 | 0 | 4 |
| DCTN1 | STC2 | 0.723082 | 4 | 0 | 3 |
| DCTN1 | FZD4 | 0.720762 | 3 | 0 | 3 |
| DCTN1 | LGI2 | 0.717181 | 3 | 0 | 3 |
| DCTN1 | GIT1 | 0.71648 | 4 | 0 | 3 |
| DCTN1 | LIPF | 0.714832 | 3 | 0 | 3 |
| DCTN1 | ERICH1 | 0.714588 | 3 | 0 | 3 |
| DCTN1 | KLF16 | 0.713874 | 3 | 0 | 3 |
| DCTN1 | IRF2BPL | 0.711918 | 3 | 0 | 3 |
For details and further investigation, click here
